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Items: 1 to 20 of 131

1.

Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

Du F, Liu Z, Li X, Xing J.

J Appl Toxicol. 2014 Aug;34(8):878-84. doi: 10.1002/jat.2906. Epub 2013 Jul 9.

PMID:
23836259
2.

Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity.

Li XX, Du FY, Liu HX, Ji JB, Xing J.

J Ethnopharmacol. 2015 Mar 13;162:238-43. doi: 10.1016/j.jep.2015.01.004. Epub 2015 Jan 9.

PMID:
25582490
3.

Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats.

Tai T, Huang X, Su Y, Ji J, Su Y, Jiang Z, Zhang L.

J Ethnopharmacol. 2014 Mar 14;152(2):358-63. doi: 10.1016/j.jep.2014.01.026. Epub 2014 Jan 30.

PMID:
24486211
4.

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.

Kong LL, Zhuang XM, Yang HY, Yuan M, Xu L, Li H.

Sci Rep. 2015 Jul 2;5:11747. doi: 10.1038/srep11747.

5.

Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.

Ye X, Li W, Yan Y, Mao C, Cai R, Xu H, Yang X.

Toxicol Lett. 2010 Feb 1;192(2):212-20. doi: 10.1016/j.toxlet.2009.10.028. Epub 2009 Oct 30.

PMID:
19879934
6.

Triptolide: progress on research in pharmacodynamics and toxicology.

Li XJ, Jiang ZZ, Zhang LY.

J Ethnopharmacol. 2014 Aug 8;155(1):67-79. doi: 10.1016/j.jep.2014.06.006. Epub 2014 Jun 13. Review.

PMID:
24933225
7.

Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.

Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J.

Toxicol Lett. 2011 Aug 10;205(1):47-54. doi: 10.1016/j.toxlet.2011.05.003. Epub 2011 May 10.

PMID:
21596114
8.

In vivo effect of triptolide combined with glycyrrhetinic acid on rat cytochrome P450 enzymes.

Han FM, Peng ZH, Wang JJ, Chen Y.

Yao Xue Xue Bao. 2013 Jul;48(7):1136-41.

PMID:
24133982
9.

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.

Shen G, Zhuang X, Xiao W, Kong L, Tan Y, Li H.

Food Chem Toxicol. 2014 Sep;71:90-6. doi: 10.1016/j.fct.2014.05.020. Epub 2014 Jun 6.

PMID:
24910460
10.

Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.

Qu L, Qu F, Jia Z, Wang C, Wu C, Zhang J.

J Ethnopharmacol. 2015 Jul 21;170:28-38. doi: 10.1016/j.jep.2015.05.010. Epub 2015 May 13.

PMID:
25978956
11.
12.

Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model.

Zhuang XM, Shen GL, Xiao WB, Tan Y, Lu C, Li H.

Drug Metab Dispos. 2013 Dec;41(12):2158-65. doi: 10.1124/dmd.113.054056. Epub 2013 Sep 24.

13.

Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran.

Ravindranath V, Boyd MR.

Biochem Pharmacol. 1991 May 1;41(9):1311-8.

PMID:
2018563
14.

[Pharmacokinetics of triptolide in Beagle dogs].

Shao F, Wang GJ, Sun JG, Xie HT, Zhang R, Zhu XY.

Yao Xue Xue Bao. 2007 Jan;42(1):61-5. Chinese.

PMID:
17520809
15.

Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.

Peng ZH, Wang JJ, Du P, Chen Y.

J Pharm Biomed Anal. 2012 Nov;70:624-30. doi: 10.1016/j.jpba.2012.06.026. Epub 2012 Jun 30.

PMID:
22824635
16.

Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes.

Li W, Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Huo H, Liu HT, Wang LM, Sun J, Wang Q, Yang L.

Xenobiotica. 2008 Dec;38(12):1551-65. doi: 10.1080/00498250802503359.

PMID:
18982531
17.

Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques.

Du F, Liu T, Liu T, Wang Y, Wan Y, Xing J.

Rapid Commun Mass Spectrom. 2011 Oct 30;25(20):3167-77. doi: 10.1002/rcm.5211.

PMID:
21953973
18.

Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.

Jurima-Romet M, Huang HS.

Biochem Pharmacol. 1992 Nov 3;44(9):1803-10.

PMID:
1449535
19.

Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats.

Xue M, Zhao Y, Li XJ, Jiang ZZ, Zhang L, Liu SH, Li XM, Zhang LY, Yang SY.

Eur J Pharm Sci. 2012 Nov 20;47(4):713-7. doi: 10.1016/j.ejps.2012.05.012. Epub 2012 Jun 5.

PMID:
22677813
20.
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