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Results: 1 to 20 of 107

Similar articles for PubMed (Select 23821265)

1.

Surface plasmon resonance as a tool to select potent drug candidates for hepatitis C virus NS5B polymerase.

Cleiren E, Devogelaere B, Fierens K.

Methods Mol Biol. 2013;1030:129-36. doi: 10.1007/978-1-62703-484-5_11.

PMID:
23821265
2.

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.

Manfroni G, Cannalire R, Barreca ML, Kaushik-Basu N, Leyssen P, Winquist J, Iraci N, Manvar D, Paeshuyse J, Guhamazumder R, Basu A, Sabatini S, Tabarrini O, Danielson UH, Neyts J, Cecchetti V.

J Med Chem. 2014 Mar 13;57(5):1952-63. doi: 10.1021/jm401362f. Epub 2013 Nov 6.

3.

Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.

LaPlante SR, Padyana AK, Abeywardane A, Bonneau P, Cartier M, Coulombe R, Jakalian A, Wildeson-Jones J, Li X, Liang S, McKercher G, White P, Zhang Q, Taylor SJ.

J Med Chem. 2014 Mar 13;57(5):2074-90. doi: 10.1021/jm401432c. Epub 2014 Jan 27.

PMID:
24467709
4.

Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase.

Winquist J, Abdurakhmanov E, Baraznenok V, Henderson I, Vrang L, Danielson UH.

Antiviral Res. 2013 Mar;97(3):356-68. doi: 10.1016/j.antiviral.2012.12.027. Epub 2013 Jan 7.

PMID:
23305851
5.

Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors.

May MM, Brohm D, Harrenga A, Marquardt T, Riedl B, Kreuter J, Zimmermann H, Ruebsamen-Schaeff H, Urban A.

Antiviral Res. 2012 Aug;95(2):182-91. doi: 10.1016/j.antiviral.2012.04.008. Epub 2012 May 10.

PMID:
22580131
6.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24.

PMID:
14684311
7.

Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.

Hang JQ, Yang Y, Harris SF, Leveque V, Whittington HJ, Rajyaguru S, Ao-Ieong G, McCown MF, Wong A, Giannetti AM, Le Pogam S, Talamás F, Cammack N, Nájera I, Klumpp K.

J Biol Chem. 2009 Jun 5;284(23):15517-29. doi: 10.1074/jbc.M808889200. Epub 2009 Feb 26.

8.

Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.

Gentles RG, Sheriff S, Beno BR, Wan C, Kish K, Ding M, Zheng X, Chupak L, Poss MA, Witmer MR, Morin P, Wang YK, Rigat K, Lemm J, Voss S, Liu M, Pelosi L, Roberts SB, Gao M, Kadow JF.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2212-5. doi: 10.1016/j.bmcl.2011.03.011. Epub 2011 Mar 6. Erratum in: Bioorg Med Chem Lett. 2011 Sep 15;21(18):5650-1.

PMID:
21441029
9.

Current perspective of HCV NS5B inhibitors: a review.

Patil VM, Gupta SP, Samanta S, Masand N.

Curr Med Chem. 2011;18(36):5564-97. Review.

PMID:
22172066
10.

Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.

Beaulieu PL, Tsantrizos YS.

Curr Opin Investig Drugs. 2004 Aug;5(8):838-50. Review.

PMID:
15600240
11.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):967-71.

PMID:
15013003
12.

Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase.

Kukolj G, McGibbon GA, McKercher G, Marquis M, Lefèbvre S, Thauvette L, Gauthier J, Goulet S, Poupart MA, Beaulieu PL.

J Biol Chem. 2005 Nov 25;280(47):39260-7. Epub 2005 Sep 27.

13.

A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template.

Ferrari E, Huang HC.

Methods Mol Biol. 2013;1030:81-92. doi: 10.1007/978-1-62703-484-5_7.

PMID:
23821261
14.

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.

Stammers TA, Coulombe R, Rancourt J, Thavonekham B, Fazal G, Goulet S, Jakalian A, Wernic D, Tsantrizos Y, Poupart MA, Bös M, McKercher G, Thauvette L, Kukolj G, Beaulieu PL.

Bioorg Med Chem Lett. 2013 May 1;23(9):2585-9. doi: 10.1016/j.bmcl.2013.02.110. Epub 2013 Mar 7.

PMID:
23545108
15.

Quinolones as HCV NS5B polymerase inhibitors.

Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, Xia YM, Ton TL, Shaghafi MB, Hu H, Lehoux I, To N, Young WB, Green MJ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):82-7. doi: 10.1016/j.bmcl.2010.11.068. Epub 2010 Nov 21.

PMID:
21145235
16.

Ligand-induced changes in hepatitis C virus NS5B polymerase structure.

Rigat K, Wang Y, Hudyma TW, Ding M, Zheng X, Gentles RG, Beno BR, Gao M, Roberts SB.

Antiviral Res. 2010 Nov;88(2):197-206. doi: 10.1016/j.antiviral.2010.08.014. Epub 2010 Sep 9.

PMID:
20813137
17.

Discovery of novel HCV polymerase inhibitors using pharmacophore-based virtual screening.

Kim ND, Chun H, Park SJ, Yang JW, Kim JW, Ahn SK.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3329-34. doi: 10.1016/j.bmcl.2011.04.010. Epub 2011 Apr 9.

PMID:
21531135
18.

Combining 3-D quantitative structure-activity relationship with ligand based and structure based alignment procedures for in silico screening of new hepatitis C virus NS5B polymerase inhibitors.

Musmuca I, Caroli A, Mai A, Kaushik-Basu N, Arora P, Ragno R.

J Chem Inf Model. 2010 Apr 26;50(4):662-76. doi: 10.1021/ci9004749.

PMID:
20225870
19.

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase.

Reddy TJ, Chan L, Turcotte N, Proulx M, Pereira OZ, Das SK, Siddiqui A, Wang W, Poisson C, Yannopoulos CG, Bilimoria D, L'Heureux L, Alaoui HM, Nguyen-Ba N.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3341-4.

PMID:
12951122
20.

TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.

Devogelaere B, Berke JM, Vijgen L, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Nyanguile O, Tahri A, Amssoms K, Lenz O, Cummings MD, Clayton RF, Vendeville S, Raboisson P, Simmen KA, Fanning GC, Lin TI.

Antimicrob Agents Chemother. 2012 Sep;56(9):4676-84. doi: 10.1128/AAC.00245-12. Epub 2012 Jun 18.

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