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Results: 1 to 20 of 106

1.

Modeling the coupled extracellular and intracellular environments in mammalian cell culture.

Meshram M, Naderi S, McConkey B, Ingalls B, Scharer J, Budman H.

Metab Eng. 2013 Sep;19:57-68. doi: 10.1016/j.ymben.2013.06.002. Epub 2013 Jun 25.

PMID:
23810769
[PubMed - indexed for MEDLINE]
2.

Population-based modeling of the progression of apoptosis in mammalian cell culture.

Meshram M, Naderi S, McConkey B, Budman H, Scharer J, Ingalls B.

Biotechnol Bioeng. 2012 May;109(5):1193-204. doi: 10.1002/bit.24392. Epub 2011 Dec 16.

PMID:
22125113
[PubMed - indexed for MEDLINE]
3.

Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells.

Naderi S, Meshram M, Wei C, McConkey B, Ingalls B, Budman H, Scharer J.

Biotechnol Prog. 2011 Sep-Oct;27(5):1197-205. doi: 10.1002/btpr.647. Epub 2011 May 25.

PMID:
21618458
[PubMed - indexed for MEDLINE]
4.

Metabolic analysis of antibody producing CHO cells in fed-batch production.

Dean J, Reddy P.

Biotechnol Bioeng. 2013 Jun;110(6):1735-47. doi: 10.1002/bit.24826. Epub 2013 Feb 15.

PMID:
23296898
[PubMed - indexed for MEDLINE]
5.

Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells.

Figueroa B Jr, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ.

Biotechnol Bioeng. 2007 Jul 1;97(4):877-92.

PMID:
17099908
[PubMed - indexed for MEDLINE]
6.

Changes in the quality of antibodies produced by Chinese hamster ovary cells during the death phase of cell culture.

Kaneko Y, Sato R, Aoyagi H.

J Biosci Bioeng. 2010 Mar;109(3):281-7. doi: 10.1016/j.jbiosc.2009.09.043. Epub 2009 Oct 17.

PMID:
20159578
[PubMed - indexed for MEDLINE]
7.

Dynamic model of CHO cell metabolism.

Nolan RP, Lee K.

Metab Eng. 2011 Jan;13(1):108-24. doi: 10.1016/j.ymben.2010.09.003. Epub 2010 Oct 7.

PMID:
20933095
[PubMed - indexed for MEDLINE]
8.

Bcl-x(L) mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells.

Chiang GG, Sisk WP.

Biotechnol Bioeng. 2005 Sep 30;91(7):779-92.

PMID:
15986489
[PubMed - indexed for MEDLINE]
9.

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

Chong WP, Thng SH, Hiu AP, Lee DY, Chan EC, Ho YS.

Biotechnol Bioeng. 2012 Dec;109(12):3103-11. doi: 10.1002/bit.24580. Epub 2012 Jul 4.

PMID:
22711553
[PubMed - indexed for MEDLINE]
10.

Understanding the mechanistic roles of 30Kc6 gene in apoptosis and specific productivity in antibody-producing Chinese hamster ovary cells.

Wang Z, Ma X, Fan L, Rhee WJ, Park TH, Zhao L, Tan WS.

Appl Microbiol Biotechnol. 2012 Jun;94(5):1243-53. doi: 10.1007/s00253-012-3899-1. Epub 2012 Feb 26.

PMID:
22367610
[PubMed - indexed for MEDLINE]
11.

Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster Ovary fed-batch culture.

Chong WP, Goh LT, Reddy SG, Yusufi FN, Lee DY, Wong NS, Heng CK, Yap MG, Ho YS.

Rapid Commun Mass Spectrom. 2009 Dec;23(23):3763-71. doi: 10.1002/rcm.4328.

PMID:
19902412
[PubMed - indexed for MEDLINE]
12.

Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media.

Luo J, Zhang J, Ren D, Tsai WL, Li F, Amanullah A, Hudson T.

Biotechnol Bioeng. 2012 Sep;109(9):2306-15. doi: 10.1002/bit.24510. Epub 2012 Apr 11.

PMID:
22473810
[PubMed - indexed for MEDLINE]
13.

An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.

McLeod J, O'Callaghan PM, Pybus LP, Wilkinson SJ, Root T, Racher AJ, James DC.

Biotechnol Bioeng. 2011 Sep;108(9):2193-204. doi: 10.1002/bit.23146. Epub 2011 Apr 27.

PMID:
21445882
[PubMed - indexed for MEDLINE]
14.

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells.

Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG.

Biotechnol Prog. 2009 Jul-Aug;25(4):1161-8. doi: 10.1002/btpr.192.

PMID:
19551877
[PubMed - indexed for MEDLINE]
15.

Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins.

Dorai H, Corisdeo S, Ellis D, Kinney C, Chomo M, Hawley-Nelson P, Moore G, Betenbaugh MJ, Ganguly S.

Biotechnol Bioeng. 2012 Apr;109(4):1016-30. doi: 10.1002/bit.24367. Epub 2011 Dec 1.

PMID:
22068683
[PubMed - indexed for MEDLINE]
16.

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media.

Chong WP, Yusufi FN, Lee DY, Reddy SG, Wong NS, Heng CK, Yap MG, Ho YS.

J Biotechnol. 2011 Jan 20;151(2):218-24. doi: 10.1016/j.jbiotec.2010.12.010. Epub 2010 Dec 16.

PMID:
21167884
[PubMed - indexed for MEDLINE]
17.

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture.

Selvarasu S, Ho YS, Chong WP, Wong NS, Yusufi FN, Lee YY, Yap MG, Lee DY.

Biotechnol Bioeng. 2012 Jun;109(6):1415-29. doi: 10.1002/bit.24445. Epub 2012 Jan 31.

PMID:
22252269
[PubMed - indexed for MEDLINE]
18.

Heuristic optimization of antibody production by Chinese hamster ovary cells.

Sandadi S, Ensari S, Kearns B.

Biotechnol Prog. 2005 Sep-Oct;21(5):1537-42.

PMID:
16209559
[PubMed - indexed for MEDLINE]
19.
20.

Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture.

Bailey LA, Hatton D, Field R, Dickson AJ.

Biotechnol Bioeng. 2012 Aug;109(8):2093-103.

PMID:
22896849
[PubMed - indexed for MEDLINE]

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