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23810191,14534335,16482210,12200666,21658656,15867244,19943786,15389438,15946498,12970765,17571739,17947479,18056186,16707599,14754606,18665830,24417926,16467199,24619861,25115808,17564019,16421422,14523461,22230800,16461299,22446502,15747376,15854550,18085610,18543309,15876454,20965785,12817431,12879428,17252009,17006667,22285209,23906446,23770790,12734675,19571508,16988930,24323036,14523462,22965919,19837125,19714331,26256879,25680524,24106110,22641468,17452251,21145591,25520136,17571738,24262285,15297408,17151364,16270035,16475128,16775234,15329907,16405837,25744042,16908206,24606652,24606648,20179930,18158072,24810322,15601563,15703781,20811403,16630657,24122886,24680705,23634289,16403813,15579919,23540562,24947087,24308645,25410137,24273759,24798484,12648069,20385986,12613514,22037271,18672441,23676790,25808917,22660209,25530131,23109697,12181044,25756742,15604889,23515925,17493325,19641527,26151304,19713230,21892537,19625707,23278256,24374144,24417923,23678005,33812415,17146202,25648025,23993428,20145273,23760739,25170123,23883175,23752173,25579165,24577437,19690655,11872078,23394475,24524306,24372965,24335106,21904381,20425449,24446903,20008233,24297946,24311723,23683876,21293953,28241101,25891192,12869491,24166905,24362549,20462961,24606656,24215657,25367136,25913326,25082346,24007867,22101898,24305542,24837466,26059983,21504383,25152116,27131622,20305139,23913852,27442383,25041880,25311496,17189224,28278193,23810242,20679528,27581134,27029807,21175313,26059167,28466557,30707758,24292539,34906861,23433657,17296565,15255169,22461032,21314483,12637317,24859364,30912699,20658954,24188054,28082113,29262882,24223824,26166681,24817601,21360071,22191306,19373669,21299455,26297263,25286693,28760296,21463107,16304377,23716542,26159458,24469953,24472814,25349084,29151104,19479613,24414484,30835732,20739774,20127176,16029627,24681942,20445576,33618649,25920395,17321991,19074120,20038234,27412040,19487383,23301228,23547655,31064152,29915172,27221912,12393600,27733081,24857074,23174189,23113675,35620443,20849386,24606653,29735299,19814615,22460758,28929332,21419537,24060289,27924671,29691899,24397072,21685374,16960151,23666687,17662883,18702869,28847475,20137117,24908961,25059397,19635185,24508029,26481837,28939746,24117365,19687593,15721470,23363706,24125987,25519749,25250944,22936742,23359430,33677711,23698276,30798348,22315495,31201085,24640967,26088952,25921389,24553365,18155764,28325357,28928163,19536894,26133328,31925317,26039947,24063401,24210993,25293449,25056761,23586870,24553361,28822797,25712735,29974949,16522812,18635311,21844874,23529307,25459178,23383963,25963696,23738923,23440689,18428043,29334300,29976745,27059166,20145269,30923102,23433851,22048790,29266206,29425962,27334764,24927873,26118036,25740105,25292262,26304076,27501474,24319522,7734352,28135325,25687048,23422204,25393253,21723805,24661629,26765457,17382018,33037866,21142814,25814088,16342925,31186377,15757021,25034734,24162333,26729897,25085252,20466781,30054431,33067205,24754670,27937141,22875622,30798394,25814089,27220473,24844604,20425401,24134676,23906625,27160310,19860613,20054526,29224320,26637731,21447834,24439564,31427550,29713954,16494624,29723397,26507546,20459996,25047978,24614709,24333114,30504932,25496750,29500381,29878287,26429162,24879034,31718935,30897165,24319180,23876601,25378984,24225967,29274688,24594142,26178642,24342895,27367039,24658964,25203717,32084002,21986632,24606655,26437782,20015886,27818567,31578694,15223635,20555071,12651262,28224300,25012565,28715941,28497898,30695512,30227318,20843134,25432281,20141430,32314454,34379028,23613267,26847385,20192579,26699851,32971032,26888022,24494789,33893334,24952896,21330326,22204455,24146695,24766312,26141653,24976310,19698217,32688056,30941573,28121314,21724255,18452066,17106019,33666650,20960522,17124063,25160793,34522972,24008916,20971815,11753631,23049298,16645210,30928650,28495914,24675265,31394591,29479070,18783070,25484026,31096222,30400842,32928796,30295239,30423211,28588176,34031342,23175686,35615931,35641639,24956628,36606715,11369652,35620965,36717672,25538217,20545220,16161267,23675141,21382019,29719934,26373709,32654460,25696861,17761829,26230589,32472084,20346507,22393079,24041359,31008998,34413457,29334838,31432643,29577681,32374276,22929456,27060881,27624943,25696860,28636094,24390277,18348294,31869412,30541488,27132280,28278720,18715642,20882436,28222016,28670773,18684859,19710400,28140313,26915625,28586121,25281405,32118733,31702048,27442893,25061833,28218239,24103873,27263312,30504306,23580151,19152977,22273251,27573699,24648811,33054104,21087500,16392897,25006277,26279306,32875515,34846219,26408711,20720184,33589755,25152126,25916436,24684225,29288559,28902850,33835260,26947577,22726921,30967368,24976289,24068564,11565540,18024654,30860652,30905538,25363400,32162884,36567345,35699277,35101736,24881918,33524640,28682832,27568522,25714683,24915631,30606227,27477825,23675289,15824241,27552679,24185146,28090014,22044951,26477757,27813536,20529803,24241488,33246263,29424604,26433907,11550277,27076247,31445538,28792265,32127950,35902731,35878453,30616371,27133824,25652737,24346354,34894984,31922494,28860339,28273189,23812943,30955853,30845227,37138411,23611229,28617066,28726645,26898188,25256677,27451977,25046396,27461416,27460189,36195064,31584727,34324312,24606666,26305301,26306453,33054106,24893299,21516268,23411044,31316860,35617101,31935278,25540066,33563899,25728856,26166664,25322328,25465231,30713559,25536562,30403419,18398726,30383979,22870150,33603145,36163711,33095907,24606647,22817266,24606646,33095912,29703870,29285791,25015264,34075852,32467801,28891531,34993961,22928126,24180451,31560117,23806235,34310396,36458956,30714453,19630970,34114207,25543505,28841441,33169841,31174157,27840977,34919644,33190253,18428042,26643149,31075669,27637765,32457354,34210693,28192602,23049363,27461906,31564956,28117336,33546530,23688508,29982761,8028707,32200529,3146485,32227648,24881913,25854120,25430625,35337248,25573033,27276507,28598700,28643495,36073515,27448405,32043283,13862978,21886049,29501207,36387650,33504688,21190732,34254886,28044992,33169882,36164234,34250402,17970607,34409591,32356435,27488267,27765944,18752847,13981519,34930078,10414946,24624037,34462147,31631692,32242375,24110590,12980538,28717692,33989269,32654575,2272448,25818829,36456506,7902745,27893333,36727397,34780493,8118047,26748812,36515352,26622999,27104193[uid]

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710 results

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Which method better evaluates the molecular response in newly diagnosed chronic phase chronic myeloid leukemia patients with imatinib treatment, BCR-ABL(IS) or log reduction from the baseline level?

Qin YZ, Jiang Q, Jiang H, Li JL, Li LD, Zhu HH, Lai YY, Lu XJ, Liu YR, Jiang B, Huang XJ. Qin YZ, et al. Leuk Res. 2013 Sep;37(9):1035-40. doi: 10.1016/j.leukres.2013.06.003. Epub 2013 Jun 26. Leuk Res. 2013. PMID: 23810191

Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia.

Hughes TP, Kaeda J, Branford S, Rudzki Z, Hochhaus A, Hensley ML, Gathmann I, Bolton AE, van Hoomissen IC, Goldman JM, Radich JP; International Randomised Study of Interferon versus STI571 (IRIS) Study Group. Hughes TP, et al. N Engl J Med. 2003 Oct 9;349(15):1423-32. doi: 10.1056/NEJMoa030513. N Engl J Med. 2003. PMID: 14534335 Free article. Clinical Trial.

Limited clinical value of regular bone marrow cytogenetic analysis in imatinib-treated chronic phase CML patients monitored by RQ-PCR for BCR-ABL.

Ross DM, Branford S, Moore S, Hughes TP. Ross DM, et al. Leukemia. 2006 Apr;20(4):664-70. doi: 10.1038/sj.leu.2404139. Leukemia. 2006. PMID: 16482210

Early reduction of BCR-ABL mRNA transcript levels predicts cytogenetic response in chronic phase CML patients treated with imatinib after failure of interferon alpha.

Merx K, Müller MC, Kreil S, Lahaye T, Paschka P, Schoch C, Weisser A, Kuhn C, Berger U, Gschaidmeier H, Hehlmann R, Hochhaus A. Merx K, et al. Leukemia. 2002 Sep;16(9):1579-83. doi: 10.1038/sj.leu.2402680. Leukemia. 2002. PMID: 12200666 Clinical Trial.

Molecular monitoring of imatinib in chronic myeloid leukemia patients in complete cytogenetic remission: does achievement of a stable major molecular response at any time point identify a privileged group of patients? A multicenter experience in Argentina and Uruguay.

Pavlovsky C, Giere I, Moiraghi B, Pavlovsky MA, Aranguren PN, García J, Fernandez I, Bengió R, Milone J, Labanca V, Uriarte R, Lombardi V, Reinoso FG, Magariños AE, Martinez L, Murro H, Lastiri F, Pavlovsky S. Pavlovsky C, et al. Clin Lymphoma Myeloma Leuk. 2011 Jun;11(3):280-5. doi: 10.1016/j.clml.2011.03.016. Epub 2011 Apr 20. Clin Lymphoma Myeloma Leuk. 2011. PMID: 21658656 Clinical Trial.

Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate.

Cortes J, Talpaz M, O'Brien S, Jones D, Luthra R, Shan J, Giles F, Faderl S, Verstovsek S, Garcia-Manero G, Rios MB, Kantarjian H. Cortes J, et al. Clin Cancer Res. 2005 May 1;11(9):3425-32. doi: 10.1158/1078-0432.CCR-04-2139. Clin Cancer Res. 2005. PMID: 15867244 Clinical Trial.

Molecular monitoring of response to imatinib (Glivec) in chronic myeloid leukemia patients: experience at a tertiary care hospital in Saudi Arabia.

Khalil SH, Abu-Amero KK, Al Mohareb F, Chaudhri NA. Khalil SH, et al. Genet Test Mol Biomarkers. 2010 Feb;14(1):67-74. doi: 10.1089/gtmb.2009.0126. Genet Test Mol Biomarkers. 2010. PMID: 19943786

Early prediction of molecular remission by monitoring BCR-ABL transcript levels in patients achieving a complete cytogenetic response after imatinib therapy for posttransplantation chronic myelogenous leukemia relapse.

Kim YJ, Kim DW, Lee S, Min CK, Goh HG, Kim SH, Lee JY, Kim YL, Kim HJ, Kim HJ, Lee JW, Kim TG, Min WS, Kim CC. Kim YJ, et al. Biol Blood Marrow Transplant. 2004 Oct;10(10):718-25. doi: 10.1016/j.bbmt.2004.06.033. Biol Blood Marrow Transplant. 2004. PMID: 15389438 Free article. Clinical Trial.

[Monitoring bcr/abl mRNA levels in imatinib mesylate treated chronic myeloid leukemia patients by real-time quantitative RT-PCR].

Qin YZ, Ruan GR, Liu YR, Li JL, Fu JY, Wang H, Chang Y, Jiang B, Jiang Q, Jiang H, Qiu JY, Chen SS, Lu DP. Qin YZ, et al. Zhonghua Xue Ye Xue Za Zhi. 2005 Jan;26(1):1-5. Zhonghua Xue Ye Xue Za Zhi. 2005. PMID: 15946498 Chinese.

Molecular monitoring of response to imatinib (Glivec) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission.

Paschka P, Müller MC, Merx K, Kreil S, Schoch C, Lahaye T, Weisser A, Petzold A, König H, Berger U, Gschaidmeier H, Hehlmann R, Hochhaus A. Paschka P, et al. Leukemia. 2003 Sep;17(9):1687-94. doi: 10.1038/sj.leu.2403033. Leukemia. 2003. PMID: 12970765

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