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Results: 1 to 20 of 114

1.

Sensitization of pancreatic cancer to chemoradiation by the Chk1 inhibitor MK8776.

Engelke CG, Parsels LA, Qian Y, Zhang Q, Karnak D, Robertson JR, Tanska DM, Wei D, Davis MA, Parsels JD, Zhao L, Greenson JK, Lawrence TS, Maybaum J, Morgan MA.

Clin Cancer Res. 2013 Aug 15;19(16):4412-21. doi: 10.1158/1078-0432.CCR-12-3748. Epub 2013 Jun 26.

PMID:
23804422
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS.

Cancer Res. 2010 Jun 15;70(12):4972-81. doi: 10.1158/0008-5472.CAN-09-3573. Epub 2010 May 25.

PMID:
20501833
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.

Parsels LA, Qian Y, Tanska DM, Gross M, Zhao L, Hassan MC, Arumugarajah S, Parsels JD, Hylander-Gans L, Simeone DM, Morosini D, Brown JL, Zabludoff SD, Maybaum J, Lawrence TS, Morgan MA.

Clin Cancer Res. 2011 Jun 1;17(11):3706-15. doi: 10.1158/1078-0432.CCR-10-3082. Epub 2011 Apr 11.

PMID:
21482692
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

Venkatesha VA, Parsels LA, Parsels JD, Zhao L, Zabludoff SD, Simeone DM, Maybaum J, Lawrence TS, Morgan MA.

Neoplasia. 2012 Jun;14(6):519-25.

PMID:
22787433
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo.

Montano R, Thompson R, Chung I, Hou H, Khan N, Eastman A.

BMC Cancer. 2013 Dec 21;13:604. doi: 10.1186/1471-2407-13-604.

PMID:
24359526
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.

Wei D, Parsels LA, Karnak D, Davis MA, Parsels JD, Marsh AC, Zhao L, Maybaum J, Lawrence TS, Sun Y, Morgan MA.

Clin Cancer Res. 2013 Aug 15;19(16):4422-32. doi: 10.1158/1078-0432.CCR-13-0788. Epub 2013 Jun 18.

PMID:
23780887
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.

Parsels LA, Morgan MA, Tanska DM, Parsels JD, Palmer BD, Booth RJ, Denny WA, Canman CE, Kraker AJ, Lawrence TS, Maybaum J.

Mol Cancer Ther. 2009 Jan;8(1):45-54. doi: 10.1158/1535-7163.MCT-08-0662.

PMID:
19139112
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

Fokas E, Prevo R, Pollard JR, Reaper PM, Charlton PA, Cornelissen B, Vallis KA, Hammond EM, Olcina MM, Gillies McKenna W, Muschel RJ, Brunner TB.

Cell Death Dis. 2012 Dec 6;3:e441. doi: 10.1038/cddis.2012.181.

PMID:
23222511
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts.

Rajeshkumar NV, De Oliveira E, Ottenhof N, Watters J, Brooks D, Demuth T, Shumway SD, Mizuarai S, Hirai H, Maitra A, Hidalgo M.

Clin Cancer Res. 2011 May 1;17(9):2799-806. doi: 10.1158/1078-0432.CCR-10-2580. Epub 2011 Mar 9.

PMID:
21389100
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth.

Nagaraj NS, Washington MK, Merchant NB.

Clin Cancer Res. 2011 Feb 1;17(3):483-93. doi: 10.1158/1078-0432.CCR-10-1670. Epub 2011 Jan 25.

PMID:
21266529
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.

Vance S, Liu E, Zhao L, Parsels JD, Parsels LA, Brown JL, Maybaum J, Lawrence TS, Morgan MA.

Cell Cycle. 2011 Dec 15;10(24):4321-9. doi: 10.4161/cc.10.24.18661. Epub 2011 Dec 15.

PMID:
22134241
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

Huntoon CJ, Flatten KS, Wahner Hendrickson AE, Huehls AM, Sutor SL, Kaufmann SH, Karnitz LM.

Cancer Res. 2013 Jun 15;73(12):3683-91. doi: 10.1158/0008-5472.CAN-13-0110. Epub 2013 Apr 2.

PMID:
23548269
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer.

Morgan MA, Parsels LA, Kollar LE, Normolle DP, Maybaum J, Lawrence TS.

Clin Cancer Res. 2008 Aug 15;14(16):5142-9. doi: 10.1158/1078-0432.CCR-07-4072.

PMID:
18698032
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.

Azorsa DO, Gonzales IM, Basu GD, Choudhary A, Arora S, Bisanz KM, Kiefer JA, Henderson MC, Trent JM, Von Hoff DD, Mousses S.

J Transl Med. 2009 Jun 11;7:43. doi: 10.1186/1479-5876-7-43.

PMID:
19519883
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.

Prevo R, Fokas E, Reaper PM, Charlton PA, Pollard JR, McKenna WG, Muschel RJ, Brunner TB.

Cancer Biol Ther. 2012 Sep;13(11):1072-81. doi: 10.4161/cbt.21093. Epub 2012 Jul 24.

PMID:
22825331
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.

Yong KJ, Milenic DE, Baidoo KE, Brechbiel MW.

Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1119-26. doi: 10.1016/j.ijrobp.2012.09.015. Epub 2012 Nov 29.

PMID:
23200172
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.

Guzi TJ, Paruch K, Dwyer MP, Labroli M, Shanahan F, Davis N, Taricani L, Wiswell D, Seghezzi W, Penaflor E, Bhagwat B, Wang W, Gu D, Hsieh Y, Lee S, Liu M, Parry D.

Mol Cancer Ther. 2011 Apr;10(4):591-602. doi: 10.1158/1535-7163.MCT-10-0928. Epub 2011 Feb 14.

PMID:
21321066
[PubMed - indexed for MEDLINE]
Free Article
18.

Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

Bianco C, Giovannetti E, Ciardiello F, Mey V, Nannizzi S, Tortora G, Troiani T, Pasqualetti F, Eckhardt G, de Liguoro M, Ricciardi S, Del Tacca M, Raben D, Cionini L, Danesi R.

Clin Cancer Res. 2006 Dec 1;12(23):7099-107.

PMID:
17145834
[PubMed - indexed for MEDLINE]
Free Article
19.

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

Walton MI, Eve PD, Hayes A, Valenti M, De Haven Brandon A, Box G, Boxall KJ, Aherne GW, Eccles SA, Raynaud FI, Williams DH, Reader JC, Collins I, Garrett MD.

Mol Cancer Ther. 2010 Jan;9(1):89-100. doi: 10.1158/1535-7163.MCT-09-0938. Epub 2010 Jan 6.

PMID:
20053762
[PubMed - indexed for MEDLINE]
Free Article
20.

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine.

Fredebohm J, Wolf J, Hoheisel JD, Boettcher M.

J Cell Sci. 2013 Aug 1;126(Pt 15):3380-9. doi: 10.1242/jcs.124768. Epub 2013 May 17.

PMID:
23687379
[PubMed - indexed for MEDLINE]
Free Article

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