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Results: 1 to 20 of 108

Similar articles for PubMed (Select 23798487)

1.

Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality.

Bhoskar P, Belongia B, Smith R, Yoon S, Carter T, Xu J.

Biotechnol Prog. 2013 Sep-Oct;29(5):1131-9. doi: 10.1002/btpr.1767. Epub 2013 Jun 25.

PMID:
23798487
2.

On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.

Schlatter S, Stansfield SH, Dinnis DM, Racher AJ, Birch JR, James DC.

Biotechnol Prog. 2005 Jan-Feb;21(1):122-33.

PMID:
15903249
3.

A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer?

Chusainow J, Yang YS, Yeo JH, Toh PC, Asvadi P, Wong NS, Yap MG.

Biotechnol Bioeng. 2009 Mar 1;102(4):1182-96. doi: 10.1002/bit.22158.

PMID:
18979540
4.

A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies.

Li J, Menzel C, Meier D, Zhang C, Dübel S, Jostock T.

J Immunol Methods. 2007 Jan 10;318(1-2):113-24. Epub 2006 Nov 13.

PMID:
17161420
5.

Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.

Edros RZ, McDonnell S, Al-Rubeai M.

PLoS One. 2013 Oct 17;8(10):e75935. doi: 10.1371/journal.pone.0075935. eCollection 2013.

6.

IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines.

Ho SC, Bardor M, Feng H, Mariati, Tong YW, Song Z, Yap MG, Yang Y.

J Biotechnol. 2012 Jan;157(1):130-9. doi: 10.1016/j.jbiotec.2011.09.023. Epub 2011 Oct 17.

PMID:
22024589
7.

Role of iron and sodium citrate in animal protein-free CHO cell culture medium on cell growth and monoclonal antibody production.

Bai Y, Wu C, Zhao J, Liu YH, Ding W, Ling WL.

Biotechnol Prog. 2011 Jan-Feb;27(1):209-19. doi: 10.1002/btpr.513. Epub 2010 Nov 23.

PMID:
21312368
8.

Comparison of internal ribosome entry site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells.

Ho SC, Bardor M, Li B, Lee JJ, Song Z, Tong YW, Goh LT, Yang Y.

PLoS One. 2013 May 21;8(5):e63247. doi: 10.1371/journal.pone.0063247. Print 2013.

9.

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line.

Tait AS, Hogwood CE, Smales CM, Bracewell DG.

Biotechnol Bioeng. 2012 Apr;109(4):971-82. doi: 10.1002/bit.24383. Epub 2011 Dec 12.

PMID:
22124969
10.

Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.

Pybus LP, Dean G, West NR, Smith A, Daramola O, Field R, Wilkinson SJ, James DC.

Biotechnol Bioeng. 2014 Feb;111(2):372-85. doi: 10.1002/bit.25116. Epub 2013 Nov 14.

PMID:
24081924
11.

Characterization of monoclonal antibody size variants containing extra light chains.

Lu C, Liu D, Liu H, Motchnik P.

MAbs. 2013 Jan-Feb;5(1):102-13. doi: 10.4161/mabs.22965. Epub 2012 Dec 19.

12.

Culture temperature modulates aggregation of recombinant antibody in cho cells.

Gomez N, Subramanian J, Ouyang J, Nguyen MD, Hutchinson M, Sharma VK, Lin AA, Yuk IH.

Biotechnol Bioeng. 2012 Jan;109(1):125-36. doi: 10.1002/bit.23288. Epub 2011 Oct 3.

PMID:
21965146
13.

Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability.

Ho SC, Koh EY, van Beers M, Mueller M, Wan C, Teo G, Song Z, Tong YW, Bardor M, Yang Y.

J Biotechnol. 2013 Jun 10;165(3-4):157-66. doi: 10.1016/j.jbiotec.2013.03.019. Epub 2013 Apr 10.

PMID:
23583871
14.

Efficient folding/assembly in Chinese hamster ovary cells is critical for high quality (low aggregate content) of secreted trastuzumab as well as for high production: stepwise multivariate regression analyses.

Ishii Y, Murakami J, Sasaki K, Tsukahara M, Wakamatsu K.

J Biosci Bioeng. 2014 Aug;118(2):223-30. doi: 10.1016/j.jbiosc.2014.01.013. Epub 2014 Mar 11.

PMID:
24635945
15.

Cell line-specific control of recombinant monoclonal antibody production by CHO cells.

O'Callaghan PM, McLeod J, Pybus LP, Lovelady CS, Wilkinson SJ, Racher AJ, Porter A, James DC.

Biotechnol Bioeng. 2010 Aug 15;106(6):938-51. doi: 10.1002/bit.22769.

PMID:
20589672
16.

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.

Pybus LP, James DC, Dean G, Slidel T, Hardman C, Smith A, Daramola O, Field R.

Biotechnol Prog. 2014 Jan-Feb;30(1):188-97. doi: 10.1002/btpr.1839. Epub 2013 Dec 6.

PMID:
24311306
17.

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies.

Kim M, O'Callaghan PM, Droms KA, James DC.

Biotechnol Bioeng. 2011 Oct;108(10):2434-46. doi: 10.1002/bit.23189. Epub 2011 May 19.

PMID:
21538334
18.

A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies.

Lee CJ, Seth G, Tsukuda J, Hamilton RW.

Biotechnol Bioeng. 2009 Mar 1;102(4):1107-18. doi: 10.1002/bit.22126.

PMID:
18985612
19.

Protein disulfide isomerase does not control recombinant IgG4 productivity in mammalian cell lines.

Hayes NV, Smales CM, Klappa P.

Biotechnol Bioeng. 2010 Mar 1;105(4):770-9. doi: 10.1002/bit.22587.

PMID:
19882737
20.

Metabolic analysis of antibody producing CHO cells in fed-batch production.

Dean J, Reddy P.

Biotechnol Bioeng. 2013 Jun;110(6):1735-47. doi: 10.1002/bit.24826. Epub 2013 Feb 15.

PMID:
23296898
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