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Results: 1 to 20 of 99

1.

Design, synthesis and biological evaluation of rose bengal analogues as SecA inhibitors.

Cui J, Jin J, Hsieh YH, Yang H, Ke B, Damera K, Tai PC, Wang B.

ChemMedChem. 2013 Aug;8(8):1384-93. doi: 10.1002/cmdc.201300216. Epub 2013 Jun 21.

PMID:
23794293
[PubMed - indexed for MEDLINE]
2.

Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation.

Huang YJ, Wang H, Gao FB, Li M, Yang H, Wang B, Tai PC.

ChemMedChem. 2012 Apr;7(4):571-7. doi: 10.1002/cmdc.201100594. Epub 2012 Feb 22.

PMID:
22354575
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in Bacillus subtilis.

Diao L, Dong Q, Xu Z, Yang S, Zhou J, Freudl R.

Appl Environ Microbiol. 2012 Feb;78(3):651-9. doi: 10.1128/AEM.07209-11. Epub 2011 Nov 23.

PMID:
22113913
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Alignment-independent QSAR analysis of SecA inhibitors.

Xu M, Bi Y, Zhu M, Li M.

Protein Pept Lett. 2013 Jul 1;20(7):802-7.

PMID:
23061671
[PubMed - indexed for MEDLINE]
5.

Discovery of the first SecA inhibitors using structure-based virtual screening.

Li M, Huang YJ, Tai PC, Wang B.

Biochem Biophys Res Commun. 2008 Apr 18;368(4):839-45. doi: 10.1016/j.bbrc.2008.01.135. Epub 2008 Feb 7.

PMID:
18261984
[PubMed - indexed for MEDLINE]
6.

Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors.

Segers K, Klaassen H, Economou A, Chaltin P, Anné J.

Anal Biochem. 2011 Jun 15;413(2):90-6. doi: 10.1016/j.ab.2011.02.012. Epub 2011 Feb 19.

PMID:
21338570
[PubMed - indexed for MEDLINE]
7.

Traffic jam at the bacterial sec translocase: targeting the SecA nanomotor by small-molecule inhibitors.

Segers K, Anné J.

Chem Biol. 2011 Jun 24;18(6):685-98. doi: 10.1016/j.chembiol.2011.04.007. Review.

PMID:
21700205
[PubMed - indexed for MEDLINE]
Free Article
8.

Lysine 106 of the putative catalytic ATP-binding site of the Bacillus subtilis SecA protein is required for functional complementation of Escherichia coli secA mutants in vivo.

Klose M, Schimz KL, van der Wolk J, Driessen AJ, Freudl R.

J Biol Chem. 1993 Feb 25;268(6):4504-10.

PMID:
8440733
[PubMed - indexed for MEDLINE]
Free Article
9.

In vivo and in vitro characterization of the secA gene product of Bacillus subtilis.

Takamatsu H, Fuma S, Nakamura K, Sadaie Y, Shinkai A, Matsuyama S, Mizushima S, Yamane K.

J Bacteriol. 1992 Jul;174(13):4308-16.

PMID:
1385592
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Preprotein translocation by a hybrid translocase composed of Escherichia coli and Bacillus subtilis subunits.

Swaving J, van Wely KH, Driessen AJ.

J Bacteriol. 1999 Nov;181(22):7021-7.

PMID:
10559168
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Identification of small molecule inhibitors against SecA of Candidatus Liberibacter asiaticus by structure based design.

Akula N, Trivedi P, Han FQ, Wang N.

Eur J Med Chem. 2012 Aug;54:919-24. doi: 10.1016/j.ejmech.2012.05.035. Epub 2012 Jun 2.

PMID:
22703844
[PubMed - indexed for MEDLINE]
12.

Identification of the magnesium-binding domain of the high-affinity ATP-binding site of the Bacillus subtilis and Escherichia coli SecA protein.

van der Wolk JP, Klose M, de Wit JG, den Blaauwen T, Freudl R, Driessen AJ.

J Biol Chem. 1995 Aug 11;270(32):18975-82.

PMID:
7642557
[PubMed - indexed for MEDLINE]
Free Article
13.

The bacterial ATPase SecA functions as a monomer in protein translocation.

Or E, Boyd D, Gon S, Beckwith J, Rapoport T.

J Biol Chem. 2005 Mar 11;280(10):9097-105. Epub 2004 Dec 23.

PMID:
15618215
[PubMed - indexed for MEDLINE]
Free Article
14.

Discovery of novel SecA inhibitors of Candidatus Liberibacter asiaticus by structure based design.

Akula N, Zheng H, Han FQ, Wang N.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4183-8. doi: 10.1016/j.bmcl.2011.05.086. Epub 2011 May 30.

PMID:
21684161
[PubMed - indexed for MEDLINE]
15.

The first low microM SecA inhibitors.

Chen W, Huang YJ, Gundala SR, Yang H, Li M, Tai PC, Wang B.

Bioorg Med Chem. 2010 Feb 15;18(4):1617-25. doi: 10.1016/j.bmc.2009.12.074. Epub 2010 Jan 6.

PMID:
20096592
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Nucleotide and phospholipid-dependent control of PPXD and C-domain association for SecA ATPase.

Ding H, Mukerji I, Oliver D.

Biochemistry. 2003 Nov 25;42(46):13468-75.

PMID:
14621992
[PubMed - indexed for MEDLINE]
17.

Synthesis and antibacterial activity of peptide deformylase inhibitors.

Huntington KM, Yi T, Wei Y, Pei D.

Biochemistry. 2000 Apr 18;39(15):4543-51.

PMID:
10758004
[PubMed - indexed for MEDLINE]
18.

SecB modulates the nucleotide-bound state of SecA and stimulates ATPase activity.

Miller A, Wang L, Kendall DA.

Biochemistry. 2002 Apr 23;41(16):5325-32.

PMID:
11955083
[PubMed - indexed for MEDLINE]
19.

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