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Results: 1 to 20 of 152

1.

Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.

Komatsu S, Moriya S, Che XF, Yokoyama T, Kohno N, Miyazawa K.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):41-7. doi: 10.1016/j.bbrc.2013.06.032. Epub 2013 Jun 18.

PMID:
23792097
[PubMed - indexed for MEDLINE]
2.

Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells.

Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A.

Int J Oncol. 2012 Apr;40(4):1029-39. doi: 10.3892/ijo.2011.1317. Epub 2011 Dec 23.

PMID:
22200786
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells.

Moriya S, Che XF, Komatsu S, Abe A, Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K.

Int J Oncol. 2013 May;42(5):1541-50. doi: 10.3892/ijo.2013.1870. Epub 2013 Mar 28.

PMID:
23546223
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress.

Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, Naito M, Itoh M, Tomoda A.

Int J Oncol. 2011 Mar;38(3):643-54. doi: 10.3892/ijo.2010.882. Epub 2010 Dec 21.

PMID:
21174067
[PubMed - indexed for MEDLINE]
5.

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

Nawrocki ST, Carew JS, Maclean KH, Courage JF, Huang P, Houghton JA, Cleveland JL, Giles FJ, McConkey DJ.

Blood. 2008 Oct 1;112(7):2917-26. doi: 10.1182/blood-2007-12-130823. Epub 2008 Jul 18.

PMID:
18641367
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents.

Namdar M, Perez G, Ngo L, Marks PA.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20003-8. doi: 10.1073/pnas.1013754107. Epub 2010 Oct 29.

PMID:
21037108
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.

Rao R, Nalluri S, Fiskus W, Savoie A, Buckley KM, Ha K, Balusu R, Joshi A, Coothankandaswamy V, Tao J, Sotomayor E, Atadja P, Bhalla KN.

Clin Cancer Res. 2010 Oct 1;16(19):4742-54. doi: 10.1158/1078-0432.CCR-10-0529. Epub 2010 Jul 20.

PMID:
20647473
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.

Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV.

Autophagy. 2010 Jan;6(1):19-35.

PMID:
20110775
[PubMed - indexed for MEDLINE]
Free Article
9.

Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality.

Yemelyanov A, Bhalla P, Yang X, Ugolkov A, Iwadate K, Karseladze A, Budunova I.

Cell Cycle. 2012 Jan 15;11(2):395-406. doi: 10.4161/cc.11.2.18945. Epub 2012 Jan 15.

PMID:
22223138
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinoma.

Vaeteewoottacharn K, Kariya R, Matsuda K, Taura M, Wongkham C, Wongkham S, Okada S.

J Cancer Res Clin Oncol. 2013 Sep;139(9):1551-62. doi: 10.1007/s00432-013-1473-6. Epub 2013 Jul 23.

PMID:
23877657
[PubMed - indexed for MEDLINE]
11.

GSK-3β signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition.

Gavilán E, Sánchez-Aguayo I, Daza P, Ruano D.

Cell Death Dis. 2013 Apr 4;4:e572. doi: 10.1038/cddis.2013.95.

PMID:
23559006
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo.

Chiu HW, Yeh YL, Wang YC, Huang WJ, Chen YA, Chiou YS, Ho SY, Lin P, Wang YJ.

PLoS One. 2013 Oct 10;8(10):e76340. doi: 10.1371/journal.pone.0076340. eCollection 2013.

PMID:
24130769
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.

Carew JS, Medina EC, Esquivel JA 2nd, Mahalingam D, Swords R, Kelly K, Zhang H, Huang P, Mita AC, Mita MM, Giles FJ, Nawrocki ST.

J Cell Mol Med. 2010 Oct;14(10):2448-59. doi: 10.1111/j.1582-4934.2009.00832.x.

PMID:
19583815
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression.

Brem GJ, Mylonas I, Brüning A.

Gynecol Oncol. 2013 Feb;128(2):383-90. doi: 10.1016/j.ygyno.2012.10.021. Epub 2012 Oct 26.

PMID:
23107612
[PubMed - indexed for MEDLINE]
15.

Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines.

Pan MY, Shen YC, Lu CH, Yang SY, Ho TF, Peng YT, Chang CC.

Toxicol Appl Pharmacol. 2012 Dec 15;265(3):325-34. doi: 10.1016/j.taap.2012.08.034. Epub 2012 Sep 12.

PMID:
22982536
[PubMed - indexed for MEDLINE]
16.

Bortezomib and SAHA synergistically induce ROS-driven caspase-dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein-Barr virus.

Hui KF, Lam BH, Ho DN, Tsao SW, Chiang AK.

Mol Cancer Ther. 2013 May;12(5):747-58. doi: 10.1158/1535-7163.MCT-12-0811. Epub 2013 Mar 8.

PMID:
23475956
[PubMed - indexed for MEDLINE]
Free Article
17.

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.

Hideshima T, Bradner JE, Wong J, Chauhan D, Richardson P, Schreiber SL, Anderson KC.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. Epub 2005 Jun 3.

PMID:
15937109
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically.

Sato A, Asano T, Ito K, Sumitomo M, Asano T.

BJU Int. 2012 Apr;109(8):1258-68. doi: 10.1111/j.1464-410X.2011.10533.x. Epub 2011 Sep 2.

PMID:
21895936
[PubMed - indexed for MEDLINE]
19.

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.

Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH.

Cancer Res. 2008 Feb 1;68(3):843-51. doi: 10.1158/0008-5472.CAN-07-5555.

PMID:
18245486
[PubMed - indexed for MEDLINE]
Free Article
20.

Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.

Heider U, von Metzler I, Kaiser M, Rosche M, Sterz J, Rötzer S, Rademacher J, Jakob C, Fleissner C, Kuckelkorn U, Kloetzel PM, Sezer O.

Eur J Haematol. 2008 Feb;80(2):133-42. Epub 2007 Dec 20.

PMID:
18005386
[PubMed - indexed for MEDLINE]

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