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Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction.

Xing Y, Gao Y, Chen J, Zhu H, Wu A, Yang Q, Teng F, Zhang DM, Xing Y, Gao K, He Q, Zhang Z, Wang J, Shang H.

Evid Based Complement Alternat Med. 2013;2013:464508. doi: 10.1155/2013/464508. Epub 2013 May 28.


Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.

Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM.

Circ Res. 2005 Dec 9;97(12):1314-22. Epub 2005 Nov 3.


Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias.

Said M, Becerra R, Valverde CA, Kaetzel MA, Dedman JR, Mundiña-Weilenmann C, Wehrens XH, Vittone L, Mattiazzi A.

J Mol Cell Cardiol. 2011 Dec;51(6):936-44. doi: 10.1016/j.yjmcc.2011.08.010. Epub 2011 Aug 19.


Calcium-calmodulin kinase II mediates digitalis-induced arrhythmias.

Gonano LA, Sepúlveda M, Rico Y, Kaetzel M, Valverde CA, Dedman J, Mattiazzi A, Vila Petroff M.

Circ Arrhythm Electrophysiol. 2011 Dec;4(6):947-57. doi: 10.1161/CIRCEP.111.964908. Epub 2011 Oct 18.


Effect of wenxin granule on ventricular remodeling and myocardial apoptosis in rats with myocardial infarction.

Wu A, Zhai J, Zhang D, Lou L, Zhu H, Gao Y, Chai L, Xing Y, Lv X, Zhu L, Zhao M, Wang S.

Evid Based Complement Alternat Med. 2013;2013:967986. doi: 10.1155/2013/967986. Epub 2013 Aug 13.


Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.

Curran J, Hinton MJ, Ríos E, Bers DM, Shannon TR.

Circ Res. 2007 Feb 16;100(3):391-8. Epub 2007 Jan 18.


Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure.

Zhang SJ, Liu ZH, Zou C, Wang L.

Chin Med J (Engl). 2012 Mar;125(5):815-22.


Sarcoplasmic reticulum Ca(2+)/Calmodulin-dependent protein kinase is altered in heart failure.

Netticadan T, Temsah RM, Kawabata K, Dhalla NS.

Circ Res. 2000 Mar 17;86(5):596-605.


Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats.

He H, Shi M, Zeng X, Yang X, Yang J, Wu L, Li L.

Phytother Res. 2008 Aug;22(8):1115-24. doi: 10.1002/ptr.2470. Retraction in: Coats A, Williamson EM. Phytother Res. 2008 Dec;22(12):1698.


Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo.

Yang Y, Zhu WZ, Joiner ML, Zhang R, Oddis CV, Hou Y, Yang J, Price EE, Gleaves L, Eren M, Ni G, Vaughan DE, Xiao RP, Anderson ME.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3065-75. Epub 2006 Jul 21.


Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release kinetics during beta-adrenergic stimulation.

Ferrero P, Said M, Sánchez G, Vittone L, Valverde C, Donoso P, Mattiazzi A, Mundiña-Weilenmann C.

J Mol Cell Cardiol. 2007 Sep;43(3):281-91. Epub 2007 Jun 6.


[Protection effect of Wenxin Keli on isoproterenol induced heart failure in rats].

Zhou F, Hu SJ, Mu Y.

Zhongguo Zhong Yao Za Zhi. 2007 Aug;32(16):1676-9. Chinese.


CaMKII-mediated increased lusitropic responses to beta-adrenoreceptor stimulation in ANP-receptor deficient mice.

Yurukova S, Kilić A, Völker K, Leineweber K, Dybkova N, Maier LS, Brodde OE, Kuhn M.

Cardiovasc Res. 2007 Mar 1;73(4):678-88. Epub 2006 Oct 7.


Dynamic alterations in the CaV1.2/CaM/CaMKII signaling pathway in the left ventricular myocardium of ischemic rat hearts.

Zhao Y, Hu HY, Sun DR, Feng R, Sun XF, Guo F, Hao LY.

DNA Cell Biol. 2014 May;33(5):282-90. doi: 10.1089/dna.2013.2231. Epub 2014 Feb 18.


Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.

Said M, Becerra R, Palomeque J, Rinaldi G, Kaetzel MA, Diaz-Sylvester PL, Copello JA, Dedman JR, Mundiña-Weilenmann C, Vittone L, Mattiazzi A.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1669-83. doi: 10.1152/ajpheart.00010.2008. Epub 2008 Aug 22.


Effects of wenxin keli on the action potential and L-type calcium current in rats with transverse aortic constriction-induced heart failure.

Chen Y, Li Y, Guo L, Chen W, Zhao M, Gao Y, Wu A, Lou L, Wang J, Liu X, Xing Y.

Evid Based Complement Alternat Med. 2013;2013:572078. doi: 10.1155/2013/572078. Epub 2013 Nov 11.


FKBP12.6 mice display temporal gender differences in cardiac Ca(2+)-signalling phenotype upon chronic pressure overload.

Prévilon M, Pezet M, Semprez F, Mercadier JJ, Rouet-Benzineb P.

Can J Physiol Pharmacol. 2011 Nov;89(11):769-82. doi: 10.1139/Y11-075. Epub 2011 Oct 18.


Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction.

Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1377-86. doi: 10.1152/ajpheart.00504.2009. Epub 2009 Jul 24.


Effects on recovery during acidosis in cardiac myocytes overexpressing CaMKII.

Sag CM, Dybkova N, Neef S, Maier LS.

J Mol Cell Cardiol. 2007 Dec;43(6):696-709. Epub 2007 Oct 22.

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