Format
Items per page
Sort by

Send to:

Choose Destination

Links from PubMed

Items: 1 to 20 of 135

1.

Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.

Hernychova L, Man P, Verma C, Nicholson J, Sharma CA, Ruckova E, Teo JY, Ball K, Vojtesek B, Hupp TR.

Proteomics. 2013 Aug;13(16):2512-25. doi: 10.1002/pmic.201300029.

PMID:
23776060
2.

Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.

Joseph TL, Madhumalar A, Brown CJ, Lane DP, Verma CS.

Cell Cycle. 2010 Mar 15;9(6):1167-81. Epub 2010 Mar 15.

PMID:
20190571
3.

A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.

Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worrall E, Hupp TR, Ball KL.

J Biol Chem. 2009 Apr 24;284(17):11517-30. doi: 10.1074/jbc.M809294200. Epub 2009 Feb 2.

4.

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.

Anil B, Riedinger C, Endicott JA, Noble ME.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1358-66. doi: 10.1107/S0907444913004459. Epub 2013 Jul 13.

PMID:
23897459
5.

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

Chee SM, Wongsantichon J, Soo Tng Q, Robinson R, Joseph TL, Verma C, Lane DP, Brown CJ, Ghadessy FJ.

PLoS One. 2014 Aug 12;9(8):e104914. doi: 10.1371/journal.pone.0104914. eCollection 2014.

6.

An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis.

Nicholson J, Neelagandan K, Huart AS, Ball K, Molloy MP, Hupp T.

J Proteome Res. 2012 Nov 2;11(11):5464-78. doi: 10.1021/pr300698d. Epub 2012 Oct 18.

PMID:
23039052
7.

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.

ElSawy KM, Verma CS, Joseph TL, Lane DP, Twarock R, Caves LS.

Cell Cycle. 2013 Feb 1;12(3):394-404. doi: 10.4161/cc.23511. Epub 2013 Jan 16.

8.

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.

Ma J, Martin JD, Zhang H, Auger KR, Ho TF, Kirkpatrick RB, Grooms MH, Johanson KO, Tummino PJ, Copeland RA, Lai Z.

Biochemistry. 2006 Aug 1;45(30):9238-45.

PMID:
16866370
9.

Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.

Shan B, Li DW, Brüschweiler-Li L, Brüschweiler R.

J Biol Chem. 2012 Aug 31;287(36):30376-84. doi: 10.1074/jbc.M112.369793. Epub 2012 Jul 17.

10.

The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2.

Worrall EG, Worrall L, Blackburn E, Walkinshaw M, Hupp TR.

J Mol Biol. 2010 May 7;398(3):414-28. doi: 10.1016/j.jmb.2010.03.023. Epub 2010 Mar 19.

PMID:
20303977
11.

MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism.

Sczaniecka M, Gladstone K, Pettersson S, McLaren L, Huart AS, Wallace M.

J Biol Chem. 2012 Apr 20;287(17):14052-68. doi: 10.1074/jbc.M111.303875. Epub 2012 Feb 15.

12.

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

Showalter SA, Bruschweiler-Li L, Johnson E, Zhang F, Brüschweiler R.

J Am Chem Soc. 2008 May 21;130(20):6472-8. doi: 10.1021/ja800201j. Epub 2008 Apr 25.

PMID:
18435534
13.

Molecular mimicry-based repositioning of nutlin-3 to anti-apoptotic Bcl-2 family proteins.

Ha JH, Won EY, Shin JS, Jang M, Ryu KS, Bae KH, Park SG, Park BC, Yoon HS, Chi SW.

J Am Chem Soc. 2011 Feb 9;133(5):1244-7. doi: 10.1021/ja109521f. Epub 2011 Jan 6.

PMID:
21210687
14.

A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.

Nicholson J, Scherl A, Way L, Blackburn EA, Walkinshaw MD, Ball KL, Hupp TR.

Cell Signal. 2014 Jun;26(6):1243-57. doi: 10.1016/j.cellsig.2014.02.011. Epub 2014 Feb 28.

PMID:
24583282
15.

Dual-site regulation of MDM2 E3-ubiquitin ligase activity.

Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL.

Mol Cell. 2006 Jul 21;23(2):251-63.

16.

The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo.

Shimizu H, Burch LR, Smith AJ, Dornan D, Wallace M, Ball KL, Hupp TR.

J Biol Chem. 2002 Aug 9;277(32):28446-58. Epub 2002 Mar 29.

17.

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.

ElSawy KM, Verma CS, Lane DP, Caves LS.

Cell Cycle. 2013 Dec 15;12(24):3727-35. doi: 10.4161/cc.27273. Epub 2013 Nov 21.

18.

In vitro selection of mutant HDM2 resistant to Nutlin inhibition.

Wei SJ, Joseph T, Sim AY, Yurlova L, Zolghadr K, Lane D, Verma C, Ghadessy F.

PLoS One. 2013 Apr 30;8(4):e62564. doi: 10.1371/journal.pone.0062564. Print 2013.

19.

Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2.

Pettersson S, Kelleher M, Pion E, Wallace M, Ball KL.

Biochem J. 2009 Mar 15;418(3):575-85. doi: 10.1042/BJ20082087.

PMID:
19032150
20.

The C terminus of p53 binds the N-terminal domain of MDM2.

Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C.

Nat Struct Mol Biol. 2010 Aug;17(8):982-9. doi: 10.1038/nsmb.1872. Epub 2010 Jul 18. Erratum in: Nat Struct Mol Biol. 2011 Apr;18(4):516.

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk