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Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression.

Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, Pfister SM, Wainwright BJ, Palma V.

Int J Cancer. 2014 Jan 1;134(1):21-31. doi: 10.1002/ijc.28330. Epub 2013 Jul 24.


Localization of SHH medulloblastoma in mice depends on the age at its initiation.

Ohli J, Neumann JE, Grammel D, Schüller U.

Acta Neuropathol. 2015 Jun 20. [Epub ahead of print] No abstract available.


Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.

Zindy F, Lee Y, Kawauchi D, Ayrault O, Merzoug LB, Li Y, McKinnon PJ, Roussel MF.

PLoS One. 2015 Jun 19;10(6):e0129642. doi: 10.1371/journal.pone.0129642. eCollection 2015.


Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Chang CF, Hsiau HI, Hung ZH, Yu MC, Chang FY.

Am J Surg. 2015 May 8. pii: S0002-9610(15)00227-5. doi: 10.1016/j.amjsurg.2015.03.001. [Epub ahead of print]


Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup.

Miele E, Mastronuzzi A, Po A, Carai A, Alfano V, Serra A, Colafati GS, Strocchio L, Antonelli M, Buttarelli FR, Zani M, Ferraro S, Buffone A, Vacca A, Screpanti I, Giangaspero F, Giannini G, Locatelli F, Ferretti E.

Biomark Res. 2015 Jun 6;3:13. doi: 10.1186/s40364-015-0038-z. eCollection 2015.


SHH inhibitors for the treatment of medulloblastoma.

Samkari A, White J, Packer R.

Expert Rev Neurother. 2015 Jul;15(7):763-70. doi: 10.1586/14737175.2015.1052796. Epub 2015 May 31.


Cooperatively Transcriptional and Epigenetic Regulation of Sonic Hedgehog Overexpression Drives Malignant Potential of Breast Cancer.

Duan ZH, Wang HC, Zhao DM, Ji XX, Song M, Yang XJ, Cui W.

Cancer Sci. 2015 May 20. doi: 10.1111/cas.12697. [Epub ahead of print]


Personalized diagnosis of medulloblastoma subtypes across patients and model systems.

Gendoo DM, Smirnov P, Lupien M, Haibe-Kains B.

Genomics. 2015 May 12. pii: S0888-7543(15)00077-4. doi: 10.1016/j.ygeno.2015.05.002. [Epub ahead of print]


Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma.

Jenkins NC, Kalra RR, Dubuc A, Sivakumar W, Pedone CA, Wu X, Taylor MD, Fults DW.

Acta Neuropathol Commun. 2014 Jul 25;2:85. doi: 10.1186/s40478-014-0085-y.


The shh signaling pathway is upregulated in multiple cell types in cortical ischemia and influences the outcome of stroke in an animal model.

Jin Y, Raviv N, Barnett A, Bambakidis NC, Filichia E, Luo Y.

PLoS One. 2015 Apr 30;10(4):e0124657. doi: 10.1371/journal.pone.0124657. eCollection 2015.


Characterization of cancer stem cells and primary cilia in medulloblastoma.

Gate D, Danielpour M, Bannykh S, Town T.

CNS Neurol Disord Drug Targets. 2015;14(5):600-11.


The Phosphoinositide 3-Kinase p110α Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma.

Salm F, Dimitrova V, von Bueren AO, Ćwiek P, Rehrauer H, Djonov V, Anderle P, Arcaro A.

PLoS One. 2015 Apr 27;10(4):e0123958. doi: 10.1371/journal.pone.0123958. eCollection 2015.


Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

Vaillant C, Valdivieso P, Nuciforo S, Kool M, Schwarzentruber-Schauerte A, Méreau H, Cabuy E, Lobrinus JA, Pfister S, Zuniga A, Frank S, Zeller R.

PLoS One. 2015 Apr 22;10(4):e0124870. doi: 10.1371/journal.pone.0124870. eCollection 2015.


Molecular development of chondrichthyan claspers and the evolution of copulatory organs.

O'Shaughnessy KL, Dahn RD, Cohn MJ.

Nat Commun. 2015 Apr 14;6:6698. doi: 10.1038/ncomms7698.


The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.

Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.

Dev Cell. 2015 Apr 6;33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26.


[Role of the Sonic Hedgehog pathway in thoracic cancers].

Giroux Leprieur E, Antoine M, Vieira T, Rozensztajn N, Ruppert AM, Rabbe N, Cadranel J, Wislez M.

Rev Mal Respir. 2015 Mar 17. pii: S0761-8425(15)00026-1. doi: 10.1016/j.rmr.2014.11.069. [Epub ahead of print] Review. French.


Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma.

Ahmad Z, Jasnos L, Gil V, Howell L, Hallsworth A, Petrie K, Sawado T, Chesler L.

PLoS One. 2015 Mar 18;10(3):e0119834. doi: 10.1371/journal.pone.0119834. eCollection 2015.


Proteomic analysis of human sonic hedgehog (SHH) medulloblastoma stem-like cells.

Ronci M, Catanzaro G, Pieroni L, Po A, Besharat ZM, Greco V, Levi Mortera S, Screpanti I, Ferretti E, Urbani A.

Mol Biosyst. 2015 May 19;11(6):1603-11. doi: 10.1039/c5mb00034c.


The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma.

Santhana Kumar K, Tripolitsioti D, Ma M, Grählert J, Egli KB, Fiaschetti G, Shalaby T, Grotzer MA, Baumgartner M.

Springerplus. 2015 Jan 14;4:19. doi: 10.1186/s40064-015-0784-2. eCollection 2015.


Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries.

Paulis L, Fauconnier J, Cazorla O, Thireau J, Soleti R, Vidal B, Ouillé A, Bartholome M, Bideaux P, Roubille F, Le Guennec JY, Andriantsitohaina R, Martínez MC, Lacampagne A.

Sci Rep. 2015 Jan 23;5:7983. doi: 10.1038/srep07983.

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