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Items: 1 to 20 of 98

1.

Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.

Witherspoon M, Chen Q, Kopelovich L, Gross SS, Lipkin SM.

Cancer Discov. 2013 Sep;3(9):1072-81. doi: 10.1158/2159-8290.CD-12-0305. Epub 2013 Jun 14.

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Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.

Koomoa DL, Yco LP, Borsics T, Wallick CJ, Bachmann AS.

Cancer Res. 2008 Dec 1;68(23):9825-31. doi: 10.1158/0008-5472.CAN-08-1865.

6.

Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells.

Selamnia M, Mayeur C, Robert V, Blachier F.

Biochem Pharmacol. 1998 Apr 15;55(8):1241-5.

PMID:
9719479
8.

Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine.

Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW.

Biochem J. 2003 Oct 15;375(Pt 2):465-70.

9.

Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

Meyskens FL Jr, Gerner EW.

Clin Cancer Res. 1999 May;5(5):945-51. Review.

10.

A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer.

Love RR, Jacoby R, Newton MA, Tutsch KD, Simon K, Pomplun M, Verma AK.

Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):989-92.

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Effects of alpha-difluoromethylornithine on the cyclin A expression in Hep-2 cells.

Marty C, Mori G, Sabini L, Rivarola V.

Biocell. 2000 Apr;24(1):49-52.

PMID:
10893799
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APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse.

Erdman SH, Ignatenko NA, Powell MB, Blohm-Mangone KA, Holubec H, Guillén-Rodriguez JM, Gerner EW.

Carcinogenesis. 1999 Sep;20(9):1709-13.

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Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps.

Meyskens FL Jr, Emerson SS, Pelot D, Meshkinpour H, Shassetz LR, Einspahr J, Alberts DS, Gerner EW.

J Natl Cancer Inst. 1994 Aug 3;86(15):1122-30.

PMID:
8028034
16.

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine.

Bacchi CJ, Garofalo J, Ciminelli M, Rattendi D, Goldberg B, McCann PP, Yarlett N.

Biochem Pharmacol. 1993 Aug 3;46(3):471-81.

PMID:
8347171
17.

Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.

Gupta S, Ahmad N, Marengo SR, MacLennan GT, Greenberg NM, Mukhtar H.

Cancer Res. 2000 Sep 15;60(18):5125-33.

19.

Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.

Kee K, Vujcic S, Merali S, Diegelman P, Kisiel N, Powell CT, Kramer DL, Porter CW.

J Biol Chem. 2004 Jun 25;279(26):27050-8. Epub 2004 Apr 19.

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