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Items: 1 to 20 of 111

1.

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.

Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J.

Nat Med. 2013 Jul;19(7):934-8. doi: 10.1038/nm.3214. Epub 2013 Jun 16.

PMID:
23770692
2.

The role of ceramide in major depressive disorder.

Kornhuber J, Reichel M, Tripal P, Groemer TW, Henkel AW, Mühle C, Gulbins E.

Eur Arch Psychiatry Clin Neurosci. 2009 Nov;259 Suppl 2:S199-204. doi: 10.1007/s00406-009-0061-x. Review.

PMID:
19876679
3.

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

Becker KA, Riethmüller J, Lüth A, Döring G, Kleuser B, Gulbins E.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):716-24. doi: 10.1165/rcmb.2009-0174OC. Epub 2009 Jul 27.

PMID:
19635928
4.

Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis.

Zhang Y, Li X, Carpinteiro A, Gulbins E.

J Immunol. 2008 Sep 15;181(6):4247-54.

5.

A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression.

Gulbins E, Walter S, Becker KA, Halmer R, Liu Y, Reichel M, Edwards MJ, Müller CP, Fassbender K, Kornhuber J.

J Neurochem. 2015 Jul;134(2):183-92. doi: 10.1111/jnc.13145. Epub 2015 May 23. Review.

PMID:
25925550
6.
7.

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis.

Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassme H, Döring G, Gulbins E.

Nat Med. 2008 Apr;14(4):382-91. doi: 10.1038/nm1748. Epub 2008 Mar 30.

PMID:
18376404
8.

Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase.

Brann AB, Tcherpakov M, Williams IM, Futerman AH, Fainzilber M.

J Biol Chem. 2002 Mar 22;277(12):9812-8. Epub 2002 Jan 3.

9.

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.

Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H.

J Mol Med (Berl). 2015 Jun;93(6):675-89. doi: 10.1007/s00109-014-1246-y. Epub 2015 Jan 25.

10.

Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice.

Boini KM, Xia M, Li C, Zhang C, Payne LP, Abais JM, Poklis JL, Hylemon PB, Li PL.

Am J Pathol. 2011 Nov;179(5):2210-9. doi: 10.1016/j.ajpath.2011.07.019. Epub 2011 Sep 3.

11.

Sphingolipids in psychiatric disorders and pain syndromes.

Mühle C, Reichel M, Gulbins E, Kornhuber J.

Handb Exp Pharmacol. 2013;(216):431-56. doi: 10.1007/978-3-7091-1511-4_22. Review.

PMID:
23563670
12.

Regulation of death receptor signaling and apoptosis by ceramide.

Gulbins E.

Pharmacol Res. 2003 May;47(5):393-9. Review.

PMID:
12676513
13.

Ceramide mediates lung fibrosis in cystic fibrosis.

Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E.

Biochem Biophys Res Commun. 2013 May 17;434(4):705-9. doi: 10.1016/j.bbrc.2013.03.032. Epub 2013 Mar 21.

14.

Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.

Dhami R, He X, Schuchman EH.

Cell Physiol Biochem. 2010;26(4-5):749-60. doi: 10.1159/000322342. Epub 2010 Oct 29.

15.

Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway.

Lee JT, Peng GS, Chen SY, Hsu CH, Lin CC, Cheng CA, Hsu YD, Lin JC.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:21-7. doi: 10.1016/j.pnpbp.2013.05.003. Epub 2013 May 9.

PMID:
23665108
16.

Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.

Liangpunsakul S, Rahmini Y, Ross RA, Zhao Z, Xu Y, Crabb DW.

Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G515-23. doi: 10.1152/ajpgi.00455.2011. Epub 2011 Dec 22.

17.

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA.

J Biol Chem. 2005 Jul 29;280(30):27879-87. Epub 2005 Jun 9.

18.

The ceramide system as a novel antidepressant target.

Kornhuber J, Müller CP, Becker KA, Reichel M, Gulbins E.

Trends Pharmacol Sci. 2014 Jun;35(6):293-304. doi: 10.1016/j.tips.2014.04.003. Epub 2014 May 1. Review.

PMID:
24793541
19.

Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.

Otala M, Pentikäinen MO, Matikainen T, Suomalainen L, Hakala JK, Perez GI, Tenhunen M, Erkkilä K, Kovanen P, Parvinen M, Dunkel L.

Biol Reprod. 2005 Jan;72(1):86-96. Epub 2004 Sep 15.

20.

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

Paris F, Grassmé H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, Kolesnick R.

J Biol Chem. 2001 Mar 16;276(11):8297-305. Epub 2000 Nov 28.

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