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Results: 1 to 20 of 104

1.

Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs.

Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J.

Nat Med. 2013 Jul;19(7):934-8. doi: 10.1038/nm.3214. Epub 2013 Jun 16.

PMID:
23770692
[PubMed - indexed for MEDLINE]
2.

The role of ceramide in major depressive disorder.

Kornhuber J, Reichel M, Tripal P, Groemer TW, Henkel AW, Mühle C, Gulbins E.

Eur Arch Psychiatry Clin Neurosci. 2009 Nov;259 Suppl 2:S199-204. doi: 10.1007/s00406-009-0061-x. Review.

PMID:
19876679
[PubMed - indexed for MEDLINE]
3.

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

Becker KA, Riethmüller J, Lüth A, Döring G, Kleuser B, Gulbins E.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):716-24. doi: 10.1165/rcmb.2009-0174OC. Epub 2009 Jul 27.

PMID:
19635928
[PubMed - indexed for MEDLINE]
4.

Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis.

Zhang Y, Li X, Carpinteiro A, Gulbins E.

J Immunol. 2008 Sep 15;181(6):4247-54.

PMID:
18768882
[PubMed - indexed for MEDLINE]
Free Article
5.

Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase.

Boini KM, Xia M, Abais JM, Xu M, Li CX, Li PL.

PLoS One. 2012;7(9):e45020. Epub 2012 Sep 14.

PMID:
23024785
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis.

Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassme H, Döring G, Gulbins E.

Nat Med. 2008 Apr;14(4):382-91. doi: 10.1038/nm1748. Epub 2008 Mar 30.

PMID:
18376404
[PubMed - indexed for MEDLINE]
7.

Regulation of death receptor signaling and apoptosis by ceramide.

Gulbins E.

Pharmacol Res. 2003 May;47(5):393-9. Review.

PMID:
12676513
[PubMed - indexed for MEDLINE]
8.

Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase.

Brann AB, Tcherpakov M, Williams IM, Futerman AH, Fainzilber M.

J Biol Chem. 2002 Mar 22;277(12):9812-8. Epub 2002 Jan 3.

PMID:
11777929
[PubMed - indexed for MEDLINE]
Free Article
9.

Acid sphingomyelinase gene deficiency ameliorates the hyperhomocysteinemia-induced glomerular injury in mice.

Boini KM, Xia M, Li C, Zhang C, Payne LP, Abais JM, Poklis JL, Hylemon PB, Li PL.

Am J Pathol. 2011 Nov;179(5):2210-9. doi: 10.1016/j.ajpath.2011.07.019. Epub 2011 Sep 3.

PMID:
21893018
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Sphingolipids in psychiatric disorders and pain syndromes.

Mühle C, Reichel M, Gulbins E, Kornhuber J.

Handb Exp Pharmacol. 2013;(216):431-56. doi: 10.1007/978-3-7091-1511-4_22. Review.

PMID:
23563670
[PubMed - indexed for MEDLINE]
11.

Ceramide mediates lung fibrosis in cystic fibrosis.

Ziobro R, Henry B, Edwards MJ, Lentsch AB, Gulbins E.

Biochem Biophys Res Commun. 2013 May 17;434(4):705-9. doi: 10.1016/j.bbrc.2013.03.032. Epub 2013 Mar 21.

PMID:
23523785
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice.

Dhami R, He X, Schuchman EH.

Cell Physiol Biochem. 2010;26(4-5):749-60. doi: 10.1159/000322342. Epub 2010 Oct 29.

PMID:
21063112
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway.

Lee JT, Peng GS, Chen SY, Hsu CH, Lin CC, Cheng CA, Hsu YD, Lin JC.

Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1;45:21-7. doi: 10.1016/j.pnpbp.2013.05.003. Epub 2013 May 9.

PMID:
23665108
[PubMed - indexed for MEDLINE]
14.

Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis.

Schmuth M, Man MQ, Weber F, Gao W, Feingold KR, Fritsch P, Elias PM, Holleran WM.

J Invest Dermatol. 2000 Sep;115(3):459-66.

PMID:
10951284
[PubMed - indexed for MEDLINE]
Free Article
15.

Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.

Liangpunsakul S, Rahmini Y, Ross RA, Zhao Z, Xu Y, Crabb DW.

Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G515-23. doi: 10.1152/ajpgi.00455.2011. Epub 2011 Dec 22.

PMID:
22194417
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA.

J Biol Chem. 2005 Jul 29;280(30):27879-87. Epub 2005 Jun 9.

PMID:
15946935
[PubMed - indexed for MEDLINE]
Free Article
17.

The ceramide system as a novel antidepressant target.

Kornhuber J, Müller CP, Becker KA, Reichel M, Gulbins E.

Trends Pharmacol Sci. 2014 Jun;35(6):293-304. doi: 10.1016/j.tips.2014.04.003. Epub 2014 May 1. Review.

PMID:
24793541
[PubMed - indexed for MEDLINE]
18.

Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet.

Deevska GM, Sunkara M, Morris AJ, Nikolova-Karakashian MN.

Biosci Rep. 2012 Oct;32(5):479-90. doi: 10.1042/BSR20120036.

PMID:
22712892
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.

Otala M, Pentikäinen MO, Matikainen T, Suomalainen L, Hakala JK, Perez GI, Tenhunen M, Erkkilä K, Kovanen P, Parvinen M, Dunkel L.

Biol Reprod. 2005 Jan;72(1):86-96. Epub 2004 Sep 15.

PMID:
15371271
[PubMed - indexed for MEDLINE]
Free Article
20.

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

Paris F, Grassmé H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, Kolesnick R.

J Biol Chem. 2001 Mar 16;276(11):8297-305. Epub 2000 Nov 28.

PMID:
11096096
[PubMed - indexed for MEDLINE]
Free Article

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