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Items: 1 to 20 of 139

1.

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J.

Nat Cell Biol. 2013 Aug;15(8):978-90. doi: 10.1038/ncb2784. Epub 2013 Jun 16.

2.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

3.

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Chen H, Ruiz PD, McKimpson WM, Novikov L, Kitsis RN, Gamble MJ.

Mol Cell. 2015 Sep 3;59(5):719-31. doi: 10.1016/j.molcel.2015.07.011. Epub 2015 Aug 20.

4.

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth.

Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, Ozturk M.

Hepatology. 2010 Sep;52(3):966-74. doi: 10.1002/hep.23769.

PMID:
20583212
5.

Transmitting senescence to the cell neighbourhood.

Hoare M, Narita M.

Nat Cell Biol. 2013 Aug;15(8):887-9. doi: 10.1038/ncb2811.

PMID:
23907191
6.

Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay.

Gu L, Kitamura M.

PLoS One. 2012;7(12):e52305. doi: 10.1371/journal.pone.0052305. Epub 2012 Dec 18.

7.

Redox control of the senescence regulator interleukin-1α and the secretory phenotype.

McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA.

J Biol Chem. 2013 Nov 8;288(45):32149-59. doi: 10.1074/jbc.M113.493841. Epub 2013 Sep 23.

8.

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.

Irvine KM, Skoien R, Bokil NJ, Melino M, Thomas GP, Loo D, Gabrielli B, Hill MM, Sweet MJ, Clouston AD, Powell EE.

World J Gastroenterol. 2014 Dec 21;20(47):17851-62. doi: 10.3748/wjg.v20.i47.17851.

9.

Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation.

Wang P, Han L, Shen H, Wang P, Lv C, Zhao G, Niu J, Xue L, Wang QJ, Tong T, Chen J.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7683-8. doi: 10.1073/pnas.1310972111. Epub 2014 May 14.

10.

Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotype.

Basu D, Reyes-Mugica M, Rebbaa A.

PLoS One. 2012;7(12):e52188. doi: 10.1371/journal.pone.0052188. Epub 2012 Dec 18.

11.

TRIM28/KAP1 regulates senescence.

Santos J, Gil J.

Immunol Lett. 2014 Nov;162(1 Pt B):281-9. doi: 10.1016/j.imlet.2014.08.011. Epub 2014 Aug 23.

PMID:
25160591
12.

IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence.

Alexander E, Hildebrand DG, Kriebs A, Obermayer K, Manz M, Rothfuss O, Schulze-Osthoff K, Essmann F.

J Cell Sci. 2013 Aug 15;126(Pt 16):3738-45. doi: 10.1242/jcs.128835. Epub 2013 Jun 18.

13.

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.

Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW.

Genes Dev. 2011 Oct 15;25(20):2125-36. doi: 10.1101/gad.17276711. Epub 2011 Oct 6.

14.

Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM.

Cell. 2013 Nov 21;155(5):1119-30. doi: 10.1016/j.cell.2013.10.041. Epub 2013 Nov 14.

15.

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype.

Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J.

Aging Cell. 2012 Aug;11(4):569-78. doi: 10.1111/j.1474-9726.2012.00818.x. Epub 2012 Apr 17.

16.

MLL1 is essential for the senescence-associated secretory phenotype.

Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL.

Genes Dev. 2016 Feb 1;30(3):321-36. doi: 10.1101/gad.271882.115.

17.

Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.

Ruan JW, Liao YC, Lua I, Li MH, Hsu CY, Chen JH.

Breast Cancer Res. 2012 Jul 12;14(4):R106. doi: 10.1186/bcr3226.

18.

PKCη promotes senescence induced by oxidative stress and chemotherapy.

Zurgil U, Ben-Ari A, Atias K, Isakov N, Apte R, Livneh E.

Cell Death Dis. 2014 Nov 20;5:e1531. doi: 10.1038/cddis.2014.481.

19.

Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1.

Mikuła-Pietrasik J, Sosińska P, Janus J, Rubiś B, Brewińska-Olchowik M, Piwocka K, Książek K.

Int J Biochem Cell Biol. 2013 Sep;45(9):2087-96. doi: 10.1016/j.biocel.2013.07.004. Epub 2013 Jul 17.

PMID:
23871936
20.

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.

Nat Cell Biol. 2015 Sep;17(9):1205-17. doi: 10.1038/ncb3225. Epub 2015 Aug 17. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370.

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