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Results: 1 to 20 of 100

1.

An in silico structure-based approach to anti-infective drug discovery.

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW.

Parasitology. 2014 Jan;141(1):17-27. doi: 10.1017/S0031182013000693. Epub 2013 Jun 17.

PMID:
23768800
[PubMed - in process]
2.

Technological advances in high-throughput screening.

Liu B, Li S, Hu J.

Am J Pharmacogenomics. 2004;4(4):263-76. Review.

PMID:
15287820
[PubMed - indexed for MEDLINE]
3.

Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors.

Vyas VK, Ghate M.

Mini Rev Med Chem. 2011 Oct;11(12):1039-55. Review.

PMID:
21861807
[PubMed - indexed for MEDLINE]
4.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
[PubMed - indexed for MEDLINE]
5.

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

Lu H, Tonge PJ.

Acc Chem Res. 2008 Jan;41(1):11-20. doi: 10.1021/ar700156e. Review.

PMID:
18193820
[PubMed - indexed for MEDLINE]
6.

Exploring novel target space: a need to partner high throughput docking and ligand-based similarity searches?

Shanmugasundaram K, Rigby AC.

Comb Chem High Throughput Screen. 2009 Dec;12(10):984-99. Review.

PMID:
20025564
[PubMed - indexed for MEDLINE]
7.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
[PubMed - indexed for MEDLINE]
8.

Streamlining lead discovery by aligning in silico and high-throughput screening.

Davies JW, Glick M, Jenkins JL.

Curr Opin Chem Biol. 2006 Aug;10(4):343-51. Epub 2006 Jul 5. Review.

PMID:
16822701
[PubMed - indexed for MEDLINE]
9.

The search for drug leads targeted to the beta-secretase: an example of the roles of computer assisted approaches in drug discovery.

Villaverde MC, González-Louro L, Sussman F.

Curr Top Med Chem. 2007;7(10):980-90. Review.

PMID:
17508931
[PubMed - indexed for MEDLINE]
10.

Fighting obesity with a sugar-based library: discovery of novel MCH-1R antagonists by a new computational-VAST approach for exploration of GPCR binding sites.

Heifetz A, Barker O, Verquin G, Wimmer N, Meutermans W, Pal S, Law RJ, Whittaker M.

J Chem Inf Model. 2013 May 24;53(5):1084-99. doi: 10.1021/ci4000882. Epub 2013 Apr 26.

PMID:
23590178
[PubMed - indexed for MEDLINE]
11.

Exploiting structural analysis, in silico screening, and serendipity to identify novel inhibitors of drug-resistant falciparum malaria.

Dasgupta T, Chitnumsub P, Kamchonwongpaisan S, Maneeruttanarungroj C, Nichols SE, Lyons TM, Tirado-Rives J, Jorgensen WL, Yuthavong Y, Anderson KS.

ACS Chem Biol. 2009 Jan 16;4(1):29-40. doi: 10.1021/cb8002804.

PMID:
19146480
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Which aspects of HTS are empirically correlated with downstream success?

Bender A, Bojanic D, Davies JW, Crisman TJ, Mikhailov D, Scheiber J, Jenkins JL, Deng Z, Hill WA, Popov M, Jacoby E, Glick M.

Curr Opin Drug Discov Devel. 2008 May;11(3):327-37. Review.

PMID:
18428086
[PubMed - indexed for MEDLINE]
13.

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics.

Obrecht D, Robinson JA, Bernardini F, Bisang C, DeMarco SJ, Moehle K, Gombert FO.

Curr Med Chem. 2009;16(1):42-65. Review.

PMID:
19149562
[PubMed - indexed for MEDLINE]
14.

Target-based and whole-worm screening approaches to anthelmintic discovery.

Kotze AC.

Vet Parasitol. 2012 May 4;186(1-2):118-23. doi: 10.1016/j.vetpar.2011.11.052. Epub 2011 Nov 20.

PMID:
22153259
[PubMed - in process]
15.

Postgenomic strategies in antibacterial drug discovery.

Brötz-Oesterhelt H, Sass P.

Future Microbiol. 2010 Oct;5(10):1553-79. doi: 10.2217/fmb.10.119. Review.

PMID:
21073314
[PubMed - indexed for MEDLINE]
Free Article
16.

The application of high-throughput screening to novel lead discovery.

Kenny BA, Bushfield M, Parry-Smith DJ, Fogarty S, Treherne JM.

Prog Drug Res. 1998;51:245-69. Review.

PMID:
9949864
[PubMed - indexed for MEDLINE]
17.

In silico identification of novel inhibitors against Plasmodium falciparum dihydroorate dehydrogenase.

Wadood A, Ulhaq ZU.

J Mol Graph Model. 2013 Mar;40:40-7. doi: 10.1016/j.jmgm.2012.11.010. Epub 2012 Dec 20.

PMID:
23353582
[PubMed - indexed for MEDLINE]
18.

Enhancing drug discovery through in silico screening: strategies to increase true positives retrieval rates.

Kirchmair J, Distinto S, Schuster D, Spitzer G, Langer T, Wolber G.

Curr Med Chem. 2008;15(20):2040-53. Review.

PMID:
18691055
[PubMed - indexed for MEDLINE]
19.

Smart screening: approaches to efficient HTS.

Engels MF, Venkatarangan P.

Curr Opin Drug Discov Devel. 2001 May;4(3):275-83. Review.

PMID:
11560058
[PubMed - indexed for MEDLINE]
20.

Fragment based drug design: from experimental to computational approaches.

Kumar A, Voet A, Zhang KY.

Curr Med Chem. 2012;19(30):5128-47. Review.

PMID:
22934764
[PubMed - indexed for MEDLINE]

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