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Items: 1 to 20 of 143


Wnt4/β-catenin signaling in medullary kidney myofibroblasts.

DiRocco DP, Kobayashi A, Taketo MM, McMahon AP, Humphreys BD.

J Am Soc Nephrol. 2013 Sep;24(9):1399-412. doi: 10.1681/ASN.2012050512. Epub 2013 Jun 13.


Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.

Wu CF, Chiang WC, Lai CF, Chang FC, Chen YT, Chou YH, Wu TH, Linn GR, Ling H, Wu KD, Tsai TJ, Chen YM, Duffield JS, Lin SL.

Am J Pathol. 2013 Jan;182(1):118-31. doi: 10.1016/j.ajpath.2012.09.009. Epub 2012 Nov 9.


Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis.

Chen YT, Chang FC, Wu CF, Chou YH, Hsu HL, Chiang WC, Shen J, Chen YM, Wu KD, Tsai TJ, Duffield JS, Lin SL.

Kidney Int. 2011 Dec;80(11):1170-81. doi: 10.1038/ki.2011.208. Epub 2011 Jun 29.


LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, Kobayashi A, Lang RA, Hadjantonakis AK, Moon RT, Duffield JS.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1440-5. doi: 10.1073/pnas.1211179110. Epub 2013 Jan 9.


Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling.

Xue H, Xiao Z, Zhang J, Wen J, Wang Y, Chang Z, Zhao J, Gao X, Du J, Chen YG.

J Biol Chem. 2013 May 24;288(21):15006-14. doi: 10.1074/jbc.M113.458448. Epub 2013 Apr 11.


Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling.

Zhou L, Li Y, Zhou D, Tan RJ, Liu Y.

J Am Soc Nephrol. 2013 Apr;24(5):771-85. doi: 10.1681/ASN.2012080865. Epub 2013 Apr 4.


Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism.

Tanigawa S, Wang H, Yang Y, Sharma N, Tarasova N, Ajima R, Yamaguchi TP, Rodriguez LG, Perantoni AO.

Dev Biol. 2011 Apr 1;352(1):58-69. doi: 10.1016/j.ydbio.2011.01.012. Epub 2011 Jan 21.


Wnt4/β-catenin signaling induces VSMC proliferation and is associated with intimal thickening.

Tsaousi A, Williams H, Lyon CA, Taylor V, Swain A, Johnson JL, George SJ.

Circ Res. 2011 Feb 18;108(4):427-36. doi: 10.1161/CIRCRESAHA.110.233999. Epub 2010 Dec 30.


A role for Wnt-4 in renal fibrosis.

Surendran K, McCaul SP, Simon TC.

Am J Physiol Renal Physiol. 2002 Mar;282(3):F431-41.


Wnt/beta-catenin signaling promotes renal interstitial fibrosis.

He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y.

J Am Soc Nephrol. 2009 Apr;20(4):765-76. doi: 10.1681/ASN.2008060566. Epub 2009 Mar 18.


R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiation.

Chassot AA, Gillot I, Chaboissier MC.

Reproduction. 2014 Dec;148(6):R97-110. doi: 10.1530/REP-14-0177. Epub 2014 Sep 3. Review.


CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury.

Surendran K, Simon TC.

Am J Physiol Renal Physiol. 2003 Apr;284(4):F653-62. Epub 2002 Dec 10.


Immunohistochemical analysis of macrophages, myofibroblasts, and transforming growth factor-beta localization during rat renal interstitial fibrosis following long-term unilateral ureteral obstruction.

Yamate J, Okado A, Kuwamura M, Tsukamoto Y, Ohashi F, Kiso Y, Nakatsuji S, Kotani T, Sakuma S, Lamarre J.

Toxicol Pathol. 1998 Nov-Dec;26(6):793-801.


WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation.

Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, Taylor RN, Bagchi MK, Bagchi IC.

Endocrinology. 2013 Jan;154(1):446-57. doi: 10.1210/en.2012-1585. Epub 2012 Nov 9.


Hedgehog-Gli pathway activation during kidney fibrosis.

Fabian SL, Penchev RR, St-Jacques B, Rao AN, Sipilä P, West KA, McMahon AP, Humphreys BD.

Am J Pathol. 2012 Apr;180(4):1441-53. doi: 10.1016/j.ajpath.2011.12.039. Epub 2012 Feb 17.


Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy.

Matsuyama M, Nomori A, Nakakuni K, Shimono A, Fukushima M.

J Biol Chem. 2014 Nov 7;289(45):31526-33. doi: 10.1074/jbc.M114.584565. Epub 2014 Sep 24.


Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner.

Carthy JM, Garmaroudi FS, Luo Z, McManus BM.

PLoS One. 2011;6(5):e19809. doi: 10.1371/journal.pone.0019809. Epub 2011 May 18.


Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition.

Liu J, Wang Y, Pan Q, Su Y, Zhang Z, Han J, Zhu X, Tang C, Hu D.

J Dermatol Sci. 2012 Jan;65(1):38-49. doi: 10.1016/j.jdermsci.2011.09.012. Epub 2011 Oct 17.


WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.

Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC.

Development. 2012 Dec 1;139(23):4461-72. doi: 10.1242/dev.078972. Epub 2012 Oct 24.

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