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Change in β-cell mass in Japanese nondiabetic obese individuals.

Kou K, Saisho Y, Satoh S, Yamada T, Itoh H.

J Clin Endocrinol Metab. 2013 Sep;98(9):3724-30. doi: 10.1210/jc.2013-1373. Epub 2013 Jun 13.


Effects of glucocorticoid treatment on beta and alpha cell mass in Japanese adults with and without diabetes.

Sato S, Saisho Y, Inaishi J, Kou K, Murakami R, Yamada T, Itoh H.

Diabetes. 2015 Apr 16. pii: db150151. [Epub ahead of print]


Automated quantification of pancreatic β-cell mass.

Golson ML, Bush WS, Brissova M.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1460-7. doi: 10.1152/ajpendo.00591.2013. Epub 2014 Apr 22.


Islet number rather than islet size is a major determinant of β- and α-cell mass in humans.

Kou K, Saisho Y, Sato S, Yamada T, Itoh H.

J Clin Endocrinol Metab. 2014 May;99(5):1733-40. doi: 10.1210/jc.2013-3731. Epub 2014 Feb 11.


Ethnic differences and β-cell changes.

Arakaki RF.

J Clin Endocrinol Metab. 2013 Sep;98(9):3595-7. doi: 10.1210/jc.2013-2935. No abstract available.


Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells.

Gonzalez A, Merino B, Marroquí L, Ñeco P, Alonso-Magdalena P, Caballero-Garrido E, Vieira E, Soriano S, Gomis R, Nadal A, Quesada I.

Endocrinology. 2013 Oct;154(10):3515-24. doi: 10.1210/en.2013-1424. Epub 2013 Jul 18.


Response to Comment on: Saisho et al. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111-117.

Saisho Y, Butler AE, Manesso E, Butler PC.

Diabetes Care. 2013 Jul;36(7):e112. doi: 10.2337/dc13-0486. No abstract available.


Comment on: Saisho et al. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 2013;36:111-117.

Gargani SA, Pattou F, Kerr-Conte J.

Diabetes Care. 2013 Jul;36(7):e111. doi: 10.2337/dc13-0220. No abstract available.


Predominance of β-cell neogenesis rather than replication in humans with an impaired glucose tolerance and newly diagnosed diabetes.

Yoneda S, Uno S, Iwahashi H, Fujita Y, Yoshikawa A, Kozawa J, Okita K, Takiuchi D, Eguchi H, Nagano H, Imagawa A, Shimomura I.

J Clin Endocrinol Metab. 2013 May;98(5):2053-61. doi: 10.1210/jc.2012-3832. Epub 2013 Mar 28.


Reduction in adiposity, β-cell function, insulin sensitivity, and cardiovascular risk factors: a prospective study among Japanese with obesity.

Goto M, Morita A, Goto A, Deura K, Sasaki S, Aiba N, Shimbo T, Terauchi Y, Miyachi M, Noda M, Watanabe S; SCOP Study Group.

PLoS One. 2013;8(3):e57964. doi: 10.1371/journal.pone.0057964. Epub 2013 Mar 6.


Islet neogenesis-associated protein (INGAP)-positive cell mass, β-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods.

Madrid V, Borelli MI, Maiztegui B, Flores LE, Gagliardino JJ, Zotto HD.

Pancreas. 2013 Apr;42(3):422-8. doi: 10.1097/MPA.0b013e318264c7bd.


Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults.

Kawamoto R, Kohara K, Kusunoki T, Tabara Y, Abe M, Miki T.

Cardiovasc Diabetol. 2012 Oct 1;11:117. doi: 10.1186/1475-2840-11-117.


Efficacy of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on body weight, eating behavior, and glycemic control, in Japanese obese type 2 diabetes.

Fujishima Y, Maeda N, Inoue K, Kashine S, Nishizawa H, Hirata A, Kozawa J, Yasuda T, Okita K, Imagawa A, Funahashi T, Shimomura I.

Cardiovasc Diabetol. 2012 Sep 14;11:107.


Quantitative determination of apoptosis of pancreatic β-cells in a murine model of type 1 diabetes mellitus.

Watanabe A, Nishijima K, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y.

J Nucl Med. 2012 Oct;53(10):1585-91. doi: 10.2967/jnumed.111.102459. Epub 2012 Aug 28.


Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial.

Kempf T, Guba-Quint A, Torgerson J, Magnone MC, Haefliger C, Bobadilla M, Wollert KC.

Eur J Endocrinol. 2012 Nov;167(5):671-8. doi: 10.1530/EJE-12-0466. Epub 2012 Aug 23.


β-cell mass and turnover in humans: effects of obesity and aging.

Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC.

Diabetes Care. 2013 Jan;36(1):111-7. doi: 10.2337/dc12-0421. Epub 2012 Aug 8.


[Pancreatic β-cell damages in obesity].

Zou DJ, Wu J.

Zhonghua Nei Ke Za Zhi. 2012 Jan;51(1):5-7. Chinese. No abstract available.


High normal HbA(1c) levels were associated with impaired insulin secretion without escalating insulin resistance in Japanese individuals: the Toranomon Hospital Health Management Center Study 8 (TOPICS 8).

Heianza Y, Arase Y, Fujihara K, Tsuji H, Saito K, Hsieh SD, Kodama S, Shimano H, Yamada N, Hara S, Sone H.

Diabet Med. 2012 Oct;29(10):1285-90. doi: 10.1111/j.1464-5491.2012.03667.x.


Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans.

Meier JJ, Breuer TG, Bonadonna RC, Tannapfel A, Uhl W, Schmidt WE, Schrader H, Menge BA.

Diabetologia. 2012 May;55(5):1346-54. doi: 10.1007/s00125-012-2466-8.


FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice.

Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, Lee YS, Amano K, Kitazumi T, Susanti VY, Kitamura YI, Kitamura T.

Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E603-13. doi: 10.​1152/​ajpendo.​00469.​2011. Epub 2012 Jan 3.

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