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Results: 1 to 20 of 104

1.

Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity.

Ross JS, Hu W, Rosen B, Snider AJ, Obeid LM, Cowart LA.

J Biol Chem. 2013 Aug 2;288(31):22193-206. doi: 10.1074/jbc.M113.477786. Epub 2013 Jun 13.

PMID:
23766515
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.

Hu W, Bielawski J, Samad F, Merrill AH Jr, Cowart LA.

J Lipid Res. 2009 Sep;50(9):1852-62. doi: 10.1194/jlr.M800635-JLR200. Epub 2009 Apr 15.

PMID:
19369694
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.

Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T.

J Cell Biochem. 2011 Nov;112(11):3449-58. doi: 10.1002/jcb.23275.

PMID:
21769916
[PubMed - indexed for MEDLINE]
4.

Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.

Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST.

Neuroscience. 2010 Mar 10;166(1):132-44. doi: 10.1016/j.neuroscience.2009.12.020. Epub 2009 Dec 28.

PMID:
20036321
[PubMed - indexed for MEDLINE]
5.

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.

Qi Y, Chen J, Lay A, Don A, Vadas M, Xia P.

FASEB J. 2013 Oct;27(10):4294-304. doi: 10.1096/fj.13-230052. Epub 2013 Jul 9.

PMID:
23839933
[PubMed - indexed for MEDLINE]
6.

The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen.

Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH.

Mol Immunol. 2011 May;48(9-10):1139-48. doi: 10.1016/j.molimm.2011.02.007. Epub 2011 Mar 23.

PMID:
21435724
[PubMed - indexed for MEDLINE]
7.

Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.

Billich A, Bornancin F, Mechtcheriakova D, Natt F, Huesken D, Baumruker T.

Cell Signal. 2005 Oct;17(10):1203-17. Epub 2005 Jan 18.

PMID:
16038795
[PubMed - indexed for MEDLINE]
8.

Sphingosine kinase 1 is a negative regulator of CD4+ Th1 cells.

Yang J, Castle BE, Hanidu A, Stevens L, Yu Y, Li X, Stearns C, Papov V, Rajotte D, Li J.

J Immunol. 2005 Nov 15;175(10):6580-8.

PMID:
16272312
[PubMed - indexed for MEDLINE]
Free Article
9.

Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.

Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D.

Circ Res. 2008 Nov 7;103(10):1164-72. doi: 10.1161/01.RES.0000338501.84810.51. Epub 2008 Oct 10.

PMID:
18849324
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells.

Böhm A, Flößer A, Ermler S, Fender AC, Lüth A, Kleuser B, Schrör K, Rauch BH.

Cardiovasc Res. 2013 Aug 1;99(3):505-13. doi: 10.1093/cvr/cvt112. Epub 2013 May 7.

PMID:
23658376
[PubMed - indexed for MEDLINE]
Free Article
11.

Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells.

Billich A, Urtz N, Reuschel R, Baumruker T.

Int J Biochem Cell Biol. 2009 Jul;41(7):1547-55. doi: 10.1016/j.biocel.2009.01.001. Epub 2009 Jan 8.

PMID:
19162217
[PubMed - indexed for MEDLINE]
12.

The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα.

Shin SS, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M.

Pharm Biol. 2012 Apr;50(4):506-15. doi: 10.3109/13880209.2011.618502. Epub 2011 Dec 1.

PMID:
22129093
[PubMed - indexed for MEDLINE]
13.

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.

Wang X, Zhang DM, Gu TT, Ding XQ, Fan CY, Zhu Q, Shi YW, Hong Y, Kong LD.

Biochem Pharmacol. 2013 Dec 15;86(12):1791-804. doi: 10.1016/j.bcp.2013.10.005. Epub 2013 Oct 14.

PMID:
24134913
[PubMed - indexed for MEDLINE]
14.

Differential regulation of sphingosine kinases 1 and 2 in lung injury.

Wadgaonkar R, Patel V, Grinkina N, Romano C, Liu J, Zhao Y, Sammani S, Garcia JG, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L603-13. doi: 10.1152/ajplung.90357.2008. Epub 2009 Jan 23.

PMID:
19168577
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.

Harijith A, Pendyala S, Reddy NM, Bai T, Usatyuk PV, Berdyshev E, Gorshkova I, Huang LS, Mohan V, Garzon S, Kanteti P, Reddy SP, Raj JU, Natarajan V.

Am J Pathol. 2013 Oct;183(4):1169-82. doi: 10.1016/j.ajpath.2013.06.018. Epub 2013 Aug 8.

PMID:
23933064
[PubMed - indexed for MEDLINE]
16.

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.

Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y, Meikle PJ, Pitson SM, Febbraio MA.

Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6.

PMID:
22961081
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP.

Cell Metab. 2005 Feb;1(2):133-44.

PMID:
16054054
[PubMed - indexed for MEDLINE]
Free Article
18.

Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes.

Ito S, Iwaki S, Koike K, Yuda Y, Nagasaki A, Ohkawa R, Yatomi Y, Furumoto T, Tsutsui H, Sobel BE, Fujii S.

Coron Artery Dis. 2013 Dec;24(8):642-50. doi: 10.1097/MCA.0000000000000033.

PMID:
24212262
[PubMed - indexed for MEDLINE]
19.

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M.

J Biol Chem. 2004 Dec 24;279(52):53994-4001. Epub 2004 Oct 12.

PMID:
15485866
[PubMed - indexed for MEDLINE]
Free Article
20.

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.

Lacaná E, Maceyka M, Milstien S, Spiegel S.

J Biol Chem. 2002 Sep 6;277(36):32947-53. Epub 2002 Jun 21.

PMID:
12080051
[PubMed - indexed for MEDLINE]
Free Article

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