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Results: 1 to 20 of 103

1.

Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ).

Kumar N, Kamenecka T, Lyda B, Khan P, Chang MR, Garcia-Ordonez RD, Cameron M, Ferguson J, Mercer BA, Hodder P, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 Mar 14].

PMID:
23762937
[PubMed]
Books & Documents
2.

Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα).

Kumar N, Nuhant P, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Ruben DGO, Burris TP, Cameron M, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Sep 1 [updated 2013 Mar 14].

PMID:
23762959
[PubMed]
Books & Documents
3.

Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, Roush WR, Griffin PR, Burris TP.

ACS Chem Biol. 2010 Nov 19;5(11):1029-34. doi: 10.1021/cb100223d.

PMID:
20735016
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR).

Kumar N, Solt LA, Conkright J, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Nuhant P, Burris T, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Jan 3 [updated 2011 Mar 11].

PMID:
21735608
[PubMed]
Books & Documents
5.

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.

Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP.

ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6.

PMID:
21090593
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).

Wang Y, Kumar N, Crumbley C, Griffin PR, Burris TP.

Biochim Biophys Acta. 2010 Aug;1801(8):917-23. doi: 10.1016/j.bbalip.2010.02.012. Epub 2010 Mar 6.

PMID:
20211758
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR.

Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3.

PMID:
19887649
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.

Jetten AM, Kurebayashi S, Ueda E.

Prog Nucleic Acid Res Mol Biol. 2001;69:205-47. Review.

PMID:
11550795
[PubMed - indexed for MEDLINE]
9.

Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

Kojima H, Muromoto R, Takahashi M, Takeuchi S, Takeda Y, Jetten AM, Matsuda T.

Toxicol Appl Pharmacol. 2012 Mar 15;259(3):338-45. doi: 10.1016/j.taap.2012.01.011. Epub 2012 Jan 24.

PMID:
22289359
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Identification of SR2211: a potent synthetic RORγ-selective modulator.

Kumar N, Lyda B, Chang MR, Lauer JL, Solt LA, Burris TP, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2012 Apr 20;7(4):672-7. doi: 10.1021/cb200496y. Epub 2012 Feb 13.

PMID:
22292739
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.

Nishiyama Y, Nakamura M, Misawa T, Nakagomi M, Makishima M, Ishikawa M, Hashimoto Y.

Bioorg Med Chem. 2014 May 1;22(9):2799-808. doi: 10.1016/j.bmc.2014.03.007. Epub 2014 Mar 17.

PMID:
24702856
[PubMed - in process]
12.

Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo.

Takeda Y, Kang HS, Angers M, Jetten AM.

Nucleic Acids Res. 2011 Jun;39(11):4769-82. doi: 10.1093/nar/gkq1335. Epub 2011 Feb 11.

PMID:
21317191
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors.

Toyama H, Nakamura M, Nakamura M, Matsumoto Y, Nakagomi M, Hashimoto Y.

Bioorg Med Chem. 2014 Mar 15;22(6):1948-59. doi: 10.1016/j.bmc.2014.01.023. Epub 2014 Feb 8.

PMID:
24559867
[PubMed - in process]
14.

Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics.

Solt LA, Griffin PR, Burris TP.

Curr Opin Lipidol. 2010 Jun;21(3):204-11. doi: 10.1097/MOL.0b013e328338ca18. Review.

PMID:
20463469
[PubMed - indexed for MEDLINE]
15.

Retinoic Acid receptor-related orphan receptor alpha-enhanced thyroid hormone receptor-mediated transcription requires its ligand binding domain which is not, by itself, sufficient: possible direct interaction of two receptors.

Qiu CH, Miyazaki W, Iwasaki T, Londoño M, Ibhazehiebo K, Shimokawa N, Koibuchi N.

Thyroid. 2009 Aug;19(8):893-8. doi: 10.1089/thy.2008.0336.

PMID:
19645616
[PubMed - indexed for MEDLINE]
16.

Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells.

Austin S, Medvedev A, Yan ZH, Adachi H, Hirose T, Jetten AM.

Cell Growth Differ. 1998 Mar;9(3):267-76.

PMID:
9543393
[PubMed - indexed for MEDLINE]
Free Article
17.

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

Wada T, Kang HS, Angers M, Gong H, Bhatia S, Khadem S, Ren S, Ellis E, Strom SC, Jetten AM, Xie W.

Mol Pharmacol. 2008 Mar;73(3):891-9. Epub 2007 Nov 30.

PMID:
18055760
[PubMed - indexed for MEDLINE]
Free Article
18.

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

Slominski AT, Kim TK, Takeda Y, Janjetovic Z, Broz˙yna AA, Skobowiat C, Wang J, Postlethwaite A, Li W, Tuckey RC, Jetten AM.

FASEB J. 2014 Jul;28(7):2775-2789. Epub 2014 Mar 25.

PMID:
24668754
[PubMed - as supplied by publisher]
19.

Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ.

Nishigori M, Nose T, Shimohigashi Y.

Toxicol Lett. 2012 Jul 20;212(2):205-11. doi: 10.1016/j.toxlet.2012.05.020. Epub 2012 May 29.

PMID:
22659100
[PubMed - indexed for MEDLINE]
20.

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation.

Takeda Y, Jetten AM.

Nucleic Acids Res. 2013 Aug;41(14):6992-7008. doi: 10.1093/nar/gkt447. Epub 2013 May 30.

PMID:
23723244
[PubMed - indexed for MEDLINE]
Free PMC Article

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