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Items: 1 to 20 of 196

1.

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.

J Biol Chem. 2013 Jul 19;288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9.

2.

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

Zhao Q, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM.

Nat Struct Mol Biol. 2009 Mar;16(3):304-11. doi: 10.1038/nsmb.1568. Epub 2009 Feb 22.

PMID:
19234465
3.

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

Fukasawa R, Tsutsui T, Hirose Y, Tanaka A, Ohkuma Y.

J Biochem. 2012 Sep;152(3):241-9. doi: 10.1093/jb/mvs065. Epub 2012 Jun 4.

PMID:
22668559
4.

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.

Pal S, Yun R, Datta A, Lacomis L, Erdjument-Bromage H, Kumar J, Tempst P, Sif S.

Mol Cell Biol. 2003 Nov;23(21):7475-87.

5.

Ras induces mediator complex exchange on C/EBP beta.

Mo X, Kowenz-Leutz E, Xu H, Leutz A.

Mol Cell. 2004 Jan 30;13(2):241-50.

6.

Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression.

Saha K, Eckert RL.

J Biol Chem. 2015 May 22;290(21):13521-30. doi: 10.1074/jbc.M115.642868. Epub 2015 Apr 7.

7.

Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.

Belakavadi M, Fondell JD.

Mol Cell Biol. 2010 May;30(10):2437-48. doi: 10.1128/MCB.01541-09. Epub 2010 Mar 15.

8.

MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.

Saha K, Adhikary G, Eckert RL.

J Invest Dermatol. 2016 Jan;136(1):214-24. doi: 10.1038/JID.2015.400.

PMID:
26763441
9.

Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.

Burgos ES, Wilczek C, Onikubo T, Bonanno JB, Jansong J, Reimer U, Shechter D.

J Biol Chem. 2015 Apr 10;290(15):9674-89. doi: 10.1074/jbc.M115.636894. Epub 2015 Feb 24.

10.

CDK8: a positive regulator of transcription.

Galbraith MD, Donner AJ, Espinosa JM.

Transcription. 2010 Jul-Aug;1(1):4-12. doi: 10.4161/trns.1.1.12373. Review.

11.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM.

Cell. 2013 Jun 6;153(6):1327-39. doi: 10.1016/j.cell.2013.04.048.

12.

A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.

Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2007 Jan;12(1):119-32.

13.

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression.

Rank G, Cerruti L, Simpson RJ, Moritz RL, Jane SM, Zhao Q.

Blood. 2010 Sep 2;116(9):1585-92. doi: 10.1182/blood-2009-10-251116. Epub 2010 May 21.

14.

Sfl1 functions via the co-repressor Ssn6-Tup1 and the cAMP-dependent protein kinase Tpk2.

Conlan RS, Tzamarias D.

J Mol Biol. 2001 Jun 22;309(5):1007-15.

PMID:
11399075
15.

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

Kowenz-Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A.

EMBO J. 2010 Mar 17;29(6):1105-15. doi: 10.1038/emboj.2010.3. Epub 2010 Jan 28.

16.

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA, Sif S.

J Biol Chem. 2013 Dec 6;288(49):35534-47. doi: 10.1074/jbc.M113.510669. Epub 2013 Nov 4.

17.

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4.

Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG.

Genes Dev. 2012 Dec 15;26(24):2749-62. doi: 10.1101/gad.203356.112.

18.

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.

Stopa N, Krebs JE, Shechter D.

Cell Mol Life Sci. 2015 Jun;72(11):2041-59. doi: 10.1007/s00018-015-1847-9. Epub 2015 Feb 7. Review.

19.

Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.

Kumafuji M, Umemura H, Furumoto T, Fukasawa R, Tanaka A, Ohkuma Y.

Genes Cells. 2014 Jul;19(7):582-93. doi: 10.1111/gtc.12155. Epub 2014 May 20.

20.

Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.

Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA.

J Biol Chem. 2013 May 17;288(20):14451-62. doi: 10.1074/jbc.M113.460840. Epub 2013 Apr 5.

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