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Results: 1 to 20 of 102

1.

Establishing a high-throughput and automated cancer cell proliferation panel for oncology lead optimization.

Lei M, Ribeiro H, Kolodin G, Gill J, Wang YS, Maloney D, Fan Y, Li S, Myer L, Beluch M, Zhang L, Schweizer L.

J Biomol Screen. 2013 Oct;18(9):1043-53. doi: 10.1177/1087057113491825. Epub 2013 Jun 3.

PMID:
23733846
[PubMed - indexed for MEDLINE]
2.

Drug design and testing: profiling of antiproliferative agents for cancer therapy using a cell-based methyl-[3H]-thymidine incorporation assay.

Griffiths M, Sundaram H.

Methods Mol Biol. 2011;731:451-65. doi: 10.1007/978-1-61779-080-5_36.

PMID:
21516428
[PubMed - indexed for MEDLINE]
3.

Profile-QSAR: a novel meta-QSAR method that combines activities across the kinase family to accurately predict affinity, selectivity, and cellular activity.

Martin E, Mukherjee P, Sullivan D, Jansen J.

J Chem Inf Model. 2011 Aug 22;51(8):1942-56. doi: 10.1021/ci1005004. Epub 2011 Jul 19.

PMID:
21667971
[PubMed - indexed for MEDLINE]
4.

GPCR assay automation for leveraging lead optimization.

Cvijic ME, Chen J, Kubala S, Nolfo J, Kolodin G, Zhang L.

J Lab Autom. 2012 Aug;17(4):266-74. doi: 10.1177/2211068212442502. Epub 2012 Apr 13.

PMID:
22505604
[PubMed - indexed for MEDLINE]
Free Article
5.

Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.

Towne DL, Nicholl EE, Comess KM, Galasinski SC, Hajduk PJ, Abraham VC.

J Biomol Screen. 2012 Sep;17(8):1005-17. doi: 10.1177/1087057112450050. Epub 2012 Jun 15.

PMID:
22706350
[PubMed - indexed for MEDLINE]
6.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
[PubMed - indexed for MEDLINE]
7.

A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale cDNA library screening.

Luesch H, Abreu P.

Methods Mol Biol. 2009;572:261-77. doi: 10.1007/978-1-60761-244-5_17.

PMID:
20694698
[PubMed - indexed for MEDLINE]
8.

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

Mathews LA, Keller JM, Goodwin BL, Guha R, Shinn P, Mull R, Thomas CJ, de Kluyver RL, Sayers TJ, Ferrer M.

J Biomol Screen. 2012 Oct;17(9):1231-42. Epub 2012 Aug 27.

PMID:
22927676
[PubMed - indexed for MEDLINE]
9.

A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays.

Chan GK, Kleinheinz TL, Peterson D, Moffat JG.

PLoS One. 2013 May 17;8(5):e63583. doi: 10.1371/journal.pone.0063583. Print 2013.

PMID:
23691072
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer.

Krasavin M, Karapetian R, Konstantinov I, Gezentsvey Y, Bukhryakov K, Godovykh E, Soldatkina O, Lavrovsky Y, Sosnov AV, Gakh AA.

Arch Pharm (Weinheim). 2009 Jul;342(7):420-7. doi: 10.1002/ardp.200800201.

PMID:
19544302
[PubMed - indexed for MEDLINE]
12.

An automated time-of-drug-addition assay to routinely determine the mode of action of HIV-1 inhibitors.

Van Loock M, Van den Eynde C, Hansen J, Geluykens P, Ivens T, Sauviller S, Bunkens L, Van Acker K, Nijs E, Dams G.

Assay Drug Dev Technol. 2013 Oct;11(8):489-500. doi: 10.1089/adt.2013.529.

PMID:
24144343
[PubMed - indexed for MEDLINE]
13.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
[PubMed - indexed for MEDLINE]
14.

A novel aminopeptidase N inhibitor developed by virtual screening approach.

Feng J, Jin K, Zhu H, Zhang X, Zhang L, Liu J, Xu W.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5863-9. doi: 10.1016/j.bmcl.2012.07.086. Epub 2012 Aug 1.

PMID:
22901392
[PubMed - indexed for MEDLINE]
15.
16.

Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Shallal HM, Russu WA.

Eur J Med Chem. 2011 Jun;46(6):2043-57. doi: 10.1016/j.ejmech.2011.02.057. Epub 2011 Mar 3.

PMID:
21429632
[PubMed - indexed for MEDLINE]
17.

Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library.

Glass LS, Bapat A, Kelley MR, Georgiadis MM, Long EC.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1685-8. doi: 10.1016/j.bmcl.2010.01.033. Epub 2010 Jan 20.

PMID:
20144868
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.

Kong D, Yamori T.

Bioorg Med Chem. 2012 Mar 15;20(6):1947-51. doi: 10.1016/j.bmc.2012.01.017. Epub 2012 Jan 21. Review.

PMID:
22336246
[PubMed - indexed for MEDLINE]
Free Article
19.

Translation of a tumor microenvironment mimicking 3D tumor growth co-culture assay platform to high-content screening.

Krausz E, de Hoogt R, Gustin E, Cornelissen F, Grand-Perret T, Janssen L, Vloemans N, Wuyts D, Frans S, Axel A, Peeters PJ, Hall B, Cik M.

J Biomol Screen. 2013 Jan;18(1):54-66. doi: 10.1177/1087057112456874. Epub 2012 Aug 24.

PMID:
22923784
[PubMed - indexed for MEDLINE]
20.

A highly automated assay for determining the aqueous equilibrium solubility of drug discovery compounds.

Wenlock MC, Austin RP, Potter T, Barton P.

J Lab Autom. 2011 Aug;16(4):276-84. doi: 10.1016/j.jala.2010.10.002. Epub 2011 Mar 26.

PMID:
21764023
[PubMed - indexed for MEDLINE]
Free Article

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