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Results: 1 to 20 of 103

1.

Discovery and development of orexin receptor antagonists as therapeutics for insomnia.

Winrow CJ, Renger JJ.

Br J Pharmacol. 2014 Jan;171(2):283-93. doi: 10.1111/bph.12261. Review.

PMID:
23731216
[PubMed - indexed for MEDLINE]
2.

Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?

Hoyer D, Jacobson LH.

Neuropeptides. 2013 Dec;47(6):477-88. doi: 10.1016/j.npep.2013.10.009. Epub 2013 Oct 23. Review.

PMID:
24215799
[PubMed - indexed for MEDLINE]
3.

Almorexant, a dual orexin receptor antagonist for the treatment of insomnia.

Neubauer DN.

Curr Opin Investig Drugs. 2010 Jan;11(1):101-10. Review.

PMID:
20047164
[PubMed - indexed for MEDLINE]
4.

Orexin receptor antagonists.

Christopher JA.

Pharm Pat Anal. 2012 Jul;1(3):329-46. doi: 10.4155/ppa.12.27. Review.

PMID:
24236845
[PubMed - indexed for MEDLINE]
5.

Examining the role of endogenous orexins in hypothalamus-pituitary-adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat.

Steiner MA, Sciarretta C, Brisbare-Roch C, Strasser DS, Studer R, Jenck F.

Psychoneuroendocrinology. 2013 Apr;38(4):560-71. doi: 10.1016/j.psyneuen.2012.07.016. Epub 2012 Aug 20.

PMID:
22917622
[PubMed - indexed for MEDLINE]
6.

Pharmacological advances in the treatment of insomnia.

Richey SM, Krystal AD.

Curr Pharm Des. 2011;17(15):1471-5. Review.

PMID:
21476952
[PubMed - indexed for MEDLINE]
7.

Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.

Mould R, Brown J, Marshall FH, Langmead CJ.

Br J Pharmacol. 2014 Jan;171(2):351-63. doi: 10.1111/bph.12245.

PMID:
23692283
[PubMed - indexed for MEDLINE]
8.

Drugs for insomnia.

Zisapel N.

Expert Opin Emerg Drugs. 2012 Sep;17(3):299-317. doi: 10.1517/14728214.2012.690735. Epub 2012 Jun 11. Review.

PMID:
22681198
[PubMed - indexed for MEDLINE]
9.

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.

Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D.

J Med Chem. 2013 Oct 10;56(19):7590-607. doi: 10.1021/jm4007627. Epub 2013 Sep 18.

PMID:
23964859
[PubMed - indexed for MEDLINE]
10.

Orexin receptors: pharmacology and therapeutic opportunities.

Scammell TE, Winrow CJ.

Annu Rev Pharmacol Toxicol. 2011;51:243-66. doi: 10.1146/annurev-pharmtox-010510-100528. Review.

PMID:
21034217
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.

Coleman PJ, Schreier JD, Cox CD, Breslin MJ, Whitman DB, Bogusky MJ, McGaughey GB, Bednar RA, Lemaire W, Doran SM, Fox SV, Garson SL, Gotter AL, Harrell CM, Reiss DR, Cabalu TD, Cui D, Prueksaritanont T, Stevens J, Tannenbaum PL, Ball RG, Stellabott J, Young SD, Hartman GD, Winrow CJ, Renger JJ.

ChemMedChem. 2012 Mar 5;7(3):415-24, 337. doi: 10.1002/cmdc.201200025. Epub 2012 Feb 3.

PMID:
22307992
[PubMed - indexed for MEDLINE]
12.

Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial.

Hoever P, Dorffner G, Beneš H, Penzel T, Danker-Hopfe H, Barbanoj MJ, Pillar G, Saletu B, Polo O, Kunz D, Zeitlhofer J, Berg S, Partinen M, Bassetti CL, Högl B, Ebrahim IO, Holsboer-Trachsler E, Bengtsson H, Peker Y, Hemmeter UM, Chiossi E, Hajak G, Dingemanse J.

Clin Pharmacol Ther. 2012 Jun;91(6):975-85. doi: 10.1038/clpt.2011.370.

PMID:
22549286
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Update on emerging drugs for insomnia.

Sullivan S.

Expert Opin Emerg Drugs. 2012 Sep;17(3):295-8. doi: 10.1517/14728214.2012.693158.

PMID:
22920041
[PubMed - indexed for MEDLINE]
14.

Orexin receptor antagonists: medicinal chemistry and therapeutic potential.

Roecker AJ, Coleman PJ.

Curr Top Med Chem. 2008;8(11):977-87. Review.

PMID:
18673167
[PubMed - indexed for MEDLINE]
15.

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.

Gotter AL, Winrow CJ, Brunner J, Garson SL, Fox SV, Binns J, Harrell CM, Cui D, Yee KL, Stiteler M, Stevens J, Savitz A, Tannenbaum PL, Tye SJ, McDonald T, Yao L, Kuduk SD, Uslaner J, Coleman PJ, Renger JJ.

BMC Neurosci. 2013 Aug 28;14:90. doi: 10.1186/1471-2202-14-90.

PMID:
23981345
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Hypocretin antagonists in insomnia treatment and beyond.

Ruoff C, Cao M, Guilleminault C.

Curr Pharm Des. 2011;17(15):1476-82. Review.

PMID:
21476951
[PubMed - indexed for MEDLINE]
17.

Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.

Herring WJ, Snyder E, Budd K, Hutzelmann J, Snavely D, Liu K, Lines C, Roth T, Michelson D.

Neurology. 2012 Dec 4;79(23):2265-74. doi: 10.1212/WNL.0b013e31827688ee. Epub 2012 Nov 28.

PMID:
23197752
[PubMed - indexed for MEDLINE]
18.

Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies.

Rosenberg RP.

Ann Clin Psychiatry. 2006 Jan-Mar;18(1):49-56. Review.

PMID:
16517453
[PubMed - indexed for MEDLINE]
19.

Food effect and biocomparison of two formulations of the dual orexin receptor antagonist almorexant in healthy male subjects.

Hoch M, Hoever P, Haschke M, Krähenbühl S, Dingemanse J.

J Clin Pharmacol. 2011 Jul;51(7):1116-21. doi: 10.1177/0091270010377634. Epub 2010 Sep 17. No abstract available.

PMID:
20852003
[PubMed - indexed for MEDLINE]
20.

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.

Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ.

Lancet Neurol. 2014 May;13(5):461-71. doi: 10.1016/S1474-4422(14)70053-5. Epub 2014 Mar 27.

PMID:
24680372
[PubMed - indexed for MEDLINE]

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