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Results: 1 to 20 of 107

1.

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia.

Gang EJ, Hsieh YT, Pham J, Zhao Y, Nguyen C, Huantes S, Park E, Naing K, Klemm L, Swaminathan S, Conway EM, Pelus LM, Crispino J, Mullighan CG, McMillan M, Müschen M, Kahn M, Kim YM.

Oncogene. 2014 Apr 24;33(17):2169-78. doi: 10.1038/onc.2013.169. Epub 2013 Jun 3.

PMID:
23728349
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells.

Kim YM, Ma H, Oehler VG, Gang EJ, Nguyen C, Masiello D, Liu H, Zhao Y, Radich J, Kahn M.

Curr Cancer Drug Targets. 2011 Feb;11(2):213-25.

PMID:
21158719
[PubMed - indexed for MEDLINE]
3.

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.

Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W.

EMBO J. 2013 Jul 17;32(14):1977-89. doi: 10.1038/emboj.2013.127. Epub 2013 Jun 4.

PMID:
23736260
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z.

J Biol Chem. 2012 Mar 2;287(10):7026-38. doi: 10.1074/jbc.M111.276311. Epub 2012 Jan 12.

PMID:
22241478
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression.

Ma H, Nguyen C, Lee KS, Kahn M.

Oncogene. 2005 May 19;24(22):3619-31.

PMID:
15782138
[PubMed - indexed for MEDLINE]
6.

Safely targeting cancer stem cells via selective catenin coactivator antagonism.

Lenz HJ, Kahn M.

Cancer Sci. 2014 Sep;105(9):1087-92. doi: 10.1111/cas.12471. Epub 2014 Sep 6. Review.

PMID:
24975284
[PubMed - indexed for MEDLINE]
7.

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.

Teo JL, Ma H, Nguyen C, Lam C, Kahn M.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12171-6. Epub 2005 Aug 10.

PMID:
16093313
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis.

Henderson WR Jr, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA, Kahn M.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14. doi: 10.1073/pnas.1001520107. Epub 2010 Jul 21.

PMID:
20660310
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo.

Kang MH, Kang YH, Szymanska B, Wilczynska-Kalak U, Sheard MA, Harned TM, Lock RB, Reynolds CP.

Blood. 2007 Sep 15;110(6):2057-66. Epub 2007 May 29.

PMID:
17536015
[PubMed - indexed for MEDLINE]
Free Article
10.

Hypoxia selects for a quiescent, CML stem/leukemia initiating-like population dependent on CBP/catenin transcription.

Kida A, Kahn M.

Curr Mol Pharmacol. 2013 Nov;6(3):204-10.

PMID:
24720539
[PubMed - in process]
11.

Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.

Hao S, He W, Li Y, Ding H, Hou Y, Nie J, Hou FF, Kahn M, Liu Y.

J Am Soc Nephrol. 2011 Sep;22(9):1642-53. doi: 10.1681/ASN.2010101079. Epub 2011 Aug 4.

PMID:
21816937
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.

Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, Debatin KM, Fulda S.

Blood. 2009 Feb 19;113(8):1710-22. doi: 10.1182/blood-2007-09-114314. Epub 2008 Nov 25.

PMID:
19036706
[PubMed - indexed for MEDLINE]
Free Article
13.

Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo.

Wei W, Chua MS, Grepper S, So S.

Int J Cancer. 2010 May 15;126(10):2426-36. doi: 10.1002/ijc.24810.

PMID:
19662654
[PubMed - indexed for MEDLINE]
14.

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells.

Leow PC, Tian Q, Ong ZY, Yang Z, Ee PL.

Invest New Drugs. 2010 Dec;28(6):766-82. doi: 10.1007/s10637-009-9311-z.

PMID:
19730790
[PubMed - indexed for MEDLINE]
15.

The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.

Sasaki T, Hwang H, Nguyen C, Kloner RA, Kahn M.

PLoS One. 2013 Sep 12;8(9):e75010. doi: 10.1371/journal.pone.0075010. eCollection 2013.

PMID:
24069374
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Small molecule antagonists of the Wnt/β-catenin signaling pathway target breast tumor-initiating cells in a Her2/Neu mouse model of breast cancer.

Hallett RM, Kondratyev MK, Giacomelli AO, Nixon AM, Girgis-Gabardo A, Ilieva D, Hassell JA.

PLoS One. 2012;7(3):e33976. doi: 10.1371/journal.pone.0033976. Epub 2012 Mar 28.

PMID:
22470504
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/β-catenin/CBP pathway.

He K, Xu T, Xu Y, Ring A, Kahn M, Goldkorn A.

Int J Cancer. 2014 Jan 1;134(1):43-54. doi: 10.1002/ijc.28341. Epub 2013 Aug 5.

PMID:
23784558
[PubMed - indexed for MEDLINE]
18.

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

Park E, Gang EJ, Hsieh YT, Schaefer P, Chae S, Klemm L, Huantes S, Loh M, Conway EM, Kang ES, Hoe Koo H, Hofmann WK, Heisterkamp N, Pelus L, Keerthivasan G, Crispino J, Kahn M, Müschen M, Kim YM.

Blood. 2011 Aug 25;118(8):2191-9. doi: 10.1182/blood-2011-04-351239. Epub 2011 Jun 28.

PMID:
21715311
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway.

Xu W, Lin H, Zhang Y, Chen X, Hua B, Hou W, Qi X, Pei Y, Zhu X, Zhao Z, Yang L.

J Exp Clin Cancer Res. 2011 Oct 28;30:103. doi: 10.1186/1756-9966-30-103.

PMID:
22032476
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats.

Chung R, Wong D, Macsai C, Piergentili A, Del Bello F, Quaglia W, Xian CJ.

Bone. 2013 Feb;52(2):651-8. doi: 10.1016/j.bone.2012.10.035. Epub 2012 Nov 10.

PMID:
23149278
[PubMed - indexed for MEDLINE]

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