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Results: 1 to 20 of 136

1.

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.

Zhu J, Wu CF, Li X, Wu GS, Xie S, Hu QN, Deng Z, Zhu MX, Luo HR, Hong X.

Bioorg Med Chem. 2013 Jul 15;21(14):4218-24. doi: 10.1016/j.bmc.2013.05.001. Epub 2013 May 9.

PMID:
23719283
[PubMed - indexed for MEDLINE]
2.

Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.

Alpan AS, Parlar S, Carlino L, Tarikogullari AH, Alptüzün V, Güneş HS.

Bioorg Med Chem. 2013 Sep 1;21(17):4928-37. doi: 10.1016/j.bmc.2013.06.065. Epub 2013 Jul 10.

PMID:
23891231
[PubMed - indexed for MEDLINE]
3.

Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.

Skrzypek A, Matysiak J, Niewiadomy A, Bajda M, Szymański P.

Eur J Med Chem. 2013 Apr;62:311-9. doi: 10.1016/j.ejmech.2012.12.060. Epub 2013 Jan 11.

PMID:
23376249
[PubMed - indexed for MEDLINE]
4.

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.

Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, Saxena A.

J Med Chem. 2005 Mar 24;48(6):1919-29.

PMID:
15771436
[PubMed - indexed for MEDLINE]
5.

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

Huang L, Shi A, He F, Li X.

Bioorg Med Chem. 2010 Feb;18(3):1244-51. doi: 10.1016/j.bmc.2009.12.035. Epub 2009 Dec 16.

PMID:
20056426
[PubMed - indexed for MEDLINE]
6.

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

Huang L, Luo Z, He F, Lu J, Li X.

Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. doi: 10.1016/j.bmc.2010.04.063. Epub 2010 Apr 27.

PMID:
20471843
[PubMed - indexed for MEDLINE]
7.

Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives.

Wu ZP, Wu XW, Shen T, Li YP, Cheng X, Gu LQ, Huang ZS, An LK.

Arch Pharm (Weinheim). 2012 Mar;345(3):175-84. doi: 10.1002/ardp.201100188. Epub 2011 Oct 12.

PMID:
21989769
[PubMed - indexed for MEDLINE]
8.

Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.

Shi A, Huang L, Lu C, He F, Li X.

Bioorg Med Chem. 2011 Apr 1;19(7):2298-305. doi: 10.1016/j.bmc.2011.02.025. Epub 2011 Feb 18.

PMID:
21397508
[PubMed - indexed for MEDLINE]
9.

Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors.

Shen Y, Li B, Xu H, Zhang G.

Pharmazie. 2013 May;68(5):307-10.

PMID:
23802426
[PubMed - indexed for MEDLINE]
10.

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.

Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.

Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.

PMID:
17681794
[PubMed - indexed for MEDLINE]
11.

Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors.

Ignasik M, Bajda M, Guzior N, Prinz M, Holzgrabe U, Malawska B.

Arch Pharm (Weinheim). 2012 Jul;345(7):509-16. doi: 10.1002/ardp.201100423. Epub 2012 Mar 30.

PMID:
22467516
[PubMed - indexed for MEDLINE]
12.

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.

Sheng R, Lin X, Zhang J, Chol KS, Huang W, Yang B, He Q, Hu Y.

Bioorg Med Chem. 2009 Sep 15;17(18):6692-8. doi: 10.1016/j.bmc.2009.07.072. Epub 2009 Aug 3.

PMID:
19692250
[PubMed - indexed for MEDLINE]
13.

Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.

Khoobi M, Alipour M, Sakhteman A, Nadri H, Moradi A, Ghandi M, Emami S, Foroumadi A, Shafiee A.

Eur J Med Chem. 2013 Oct;68:260-9. doi: 10.1016/j.ejmech.2013.07.038. Epub 2013 Aug 11.

PMID:
23988409
[PubMed - indexed for MEDLINE]
14.

[Design, synthesis and evaluation of tacrine-methoxybenzene hybrids as cholinesterases inhibitors].

Luo W, Zhao YM, Zhang Z, Su YB, Wang CJ.

Yao Xue Xue Bao. 2012 Jul;47(7):916-21. Chinese.

PMID:
22993857
[PubMed - indexed for MEDLINE]
15.

Synthesis of some new 3-coumaranone and coumarin derivatives as dual inhibitors of acetyl- and butyrylcholinesterase.

Alipour M, Khoobi M, Nadri H, Sakhteman A, Moradi A, Ghandi M, Foroumadi A, Shafiee A.

Arch Pharm (Weinheim). 2013 Aug;346(8):577-87. doi: 10.1002/ardp.201300080. Epub 2013 Jul 15.

PMID:
23852709
[PubMed - indexed for MEDLINE]
16.

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L.

Bioorg Med Chem. 2010 Aug 15;18(16):5861-72. doi: 10.1016/j.bmc.2010.06.095. Epub 2010 Jul 3.

PMID:
20656495
[PubMed - indexed for MEDLINE]
17.

Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.

Khoobi M, Alipour M, Moradi A, Sakhteman A, Nadri H, Razavi SF, Ghandi M, Foroumadi A, Shafiee A.

Eur J Med Chem. 2013 Oct;68:291-300. doi: 10.1016/j.ejmech.2013.07.045. Epub 2013 Aug 11.

PMID:
23988412
[PubMed - indexed for MEDLINE]
18.

2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.

Li Z, Wang B, Hou JQ, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.

J Enzyme Inhib Med Chem. 2013 Jun;28(3):583-92. doi: 10.3109/14756366.2012.663363. Epub 2012 Mar 1.

PMID:
22380775
[PubMed - indexed for MEDLINE]
19.

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

He Y, Yao PF, Chen SB, Huang ZH, Huang SL, Tan JH, Li D, Gu LQ, Huang ZS.

Eur J Med Chem. 2013 May;63:299-312. doi: 10.1016/j.ejmech.2013.02.014. Epub 2013 Feb 26.

PMID:
23501115
[PubMed - indexed for MEDLINE]
20.

Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.

Razavi SF, Khoobi M, Nadri H, Sakhteman A, Moradi A, Emami S, Foroumadi A, Shafiee A.

Eur J Med Chem. 2013 Jun;64:252-9. doi: 10.1016/j.ejmech.2013.03.021. Epub 2013 Mar 18.

PMID:
23644208
[PubMed - indexed for MEDLINE]

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