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Items: 1 to 20 of 105

1.

An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.

Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL.

Sci Signal. 2013 May 28;6(277):ra39. doi: 10.1126/scisignal.2003374.

2.

Adenosine promotes tumor metastasis.

Linden J.

Sci Signal. 2013 May 28;6(277):pe20. doi: 10.1126/scisignal.2004290.

PMID:
23716715
3.

A new signaling paradigm to control the prenylation and trafficking of small GTPases.

Williams CL.

Cell Cycle. 2013;12(18):2933-4. doi: 10.4161/cc.26230. Epub 2013 Aug 23. No abstract available.

4.

β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.

Wilson JM, Lorimer E, Tyburski MD, Williams CL.

Cancer Biol Ther. 2015;16(9):1364-74. doi: 10.1080/15384047.2015.1070988. Epub 2015 Jul 24.

5.

Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL.

J Biol Chem. 2010 Nov 12;285(46):35255-66. doi: 10.1074/jbc.M110.129916. Epub 2010 Aug 13.

6.

The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

Schuld NJ, Vervacke JS, Lorimer EL, Simon NC, Hauser AD, Barbieri JT, Distefano MD, Williams CL.

J Biol Chem. 2014 Mar 7;289(10):6862-76. doi: 10.1074/jbc.M113.527192. Epub 2014 Jan 10.

7.

Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.

Yan J, Li F, Ingram DA, Quilliam LA.

Mol Cell Biol. 2008 Sep;28(18):5803-10. doi: 10.1128/MCB.00393-08. Epub 2008 Jul 14.

8.

SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.

Côte M, Fos C, Canonigo-Balancio AJ, Ley K, Bécart S, Altman A.

J Cell Sci. 2015 Dec 1;128(23):4341-52. doi: 10.1242/jcs.172742. Epub 2015 Oct 19.

9.

Cyclic AMP-dependent activation of Rap1b.

Altschuler DL, Peterson SN, Ostrowski MC, Lapetina EG.

J Biol Chem. 1995 May 5;270(18):10373-6.

10.

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S.

J Thromb Haemost. 2013 Aug;11(8):1574-82. doi: 10.1111/jth.12271.

11.
12.

Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.

Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E.

Blood. 2009 Jan 8;113(2):488-97. doi: 10.1182/blood-2008-02-138438. Epub 2008 Sep 19.

13.

Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.

Guidetti GF, Manganaro D, Consonni A, Canobbio I, Balduini C, Torti M.

Biochem J. 2013 Jul 1;453(1):115-23. doi: 10.1042/BJ20130131.

PMID:
23600630
14.

A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.

Lova P, Paganini S, Sinigaglia F, Balduini C, Torti M.

J Biol Chem. 2002 Apr 5;277(14):12009-15. Epub 2002 Jan 28.

15.

The structure and conformational switching of Rap1B.

Noguchi H, Ikegami T, Nagadoi A, Kamatari YO, Park SY, Tame JR, Unzai S.

Biochem Biophys Res Commun. 2015 Jun 19;462(1):46-51. doi: 10.1016/j.bbrc.2015.04.103. Epub 2015 Apr 29.

16.

Protein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration.

Takahashi M, Dillon TJ, Liu C, Kariya Y, Wang Z, Stork PJ.

J Biol Chem. 2013 Sep 27;288(39):27712-23. doi: 10.1074/jbc.M113.466904. Epub 2013 Aug 14.

17.

Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.

Muñoz-Llancao P, Henríquez DR, Wilson C, Bodaleo F, Boddeke EW, Lezoualc'h F, Schmidt M, González-Billault C.

J Neurosci. 2015 Aug 12;35(32):11315-29. doi: 10.1523/JNEUROSCI.3645-14.2015.

18.

Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.

Murphy MM, Zayed MA, Evans A, Parker CE, Ataga KI, Telen MJ, Parise LV.

Blood. 2005 Apr 15;105(8):3322-9. Epub 2004 Dec 21.

19.

Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.

Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94. doi: 10.1161/ATVBAHA.114.303678. Epub 2014 May 1.

20.

Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.

McSherry EA, Brennan K, Hudson L, Hill AD, Hopkins AM.

Breast Cancer Res. 2011 Mar 23;13(2):R31. doi: 10.1186/bcr2853.

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