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Items: 1 to 20 of 105

1.

Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure-activity relationships of CCR8 ligands.

Petersen TP, Mirsharghi S, Rummel PC, Thiele S, Rosenkilde MM, Ritzén A, Ulven T.

Chemistry. 2013 Jul 8;19(28):9343-50. doi: 10.1002/chem.201204350. Epub 2013 May 28.

PMID:
23716302
2.

Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.

Jensen PC, Thiele S, Steen A, Elder A, Kolbeck R, Ghosh S, Frimurer TM, Rosenkilde MM.

Br J Pharmacol. 2012 May;166(1):258-75. doi: 10.1111/j.1476-5381.2011.01771.x.

3.

Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.

Rummel PC, Arfelt KN, Baumann L, Jenkins TJ, Thiele S, Lüttichau HR, Johnsen A, Pease J, Ghosh S, Kolbeck R, Rosenkilde MM.

Br J Pharmacol. 2012 Nov;167(6):1206-17. doi: 10.1111/j.1476-5381.2012.02076.x.

4.

A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands.

Petersen TP, Ritzén A, Ulven T.

Org Lett. 2009 Nov 19;11(22):5134-7. doi: 10.1021/ol902101c.

PMID:
19852497
5.

Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators.

Chalikiopoulos A, Thiele S, Malmgaard-Clausen M, Rydberg P, Isberg V, Ulven T, Frimurer TM, Rosenkilde MM, Gloriam DE.

J Chem Inf Model. 2013 Nov 25;53(11):2863-73. doi: 10.1021/ci4003848. Epub 2013 Oct 22.

PMID:
24083637
6.

1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.

Sorbi C, Franchini S, Tait A, Prandi A, Gallesi R, Angeli P, Marucci G, Pirona L, Poggesi E, Brasili L.

ChemMedChem. 2009 Mar;4(3):393-9. doi: 10.1002/cmdc.200800277.

PMID:
19152363
7.

Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8.

Jenkins TJ, Guan B, Dai M, Li G, Lightburn TE, Huang S, Freeze BS, Burdi DF, Jacutin-Porte S, Bennett R, Chen W, Minor C, Ghosh S, Blackburn C, Gigstad KM, Jones M, Kolbeck R, Yin W, Smith S, Cardillo D, Ocain TD, Harriman GC.

J Med Chem. 2007 Feb 8;50(3):566-84.

PMID:
17266208
8.

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8.

Jensen PC, Nygaard R, Thiele S, Elder A, Zhu G, Kolbeck R, Ghosh S, Schwartz TW, Rosenkilde MM.

Mol Pharmacol. 2007 Aug;72(2):327-40. Erratum in: Mol Pharmacol. 2008 Aug;74(2):539. Mol Pharmacol. 2007 Oct;72(4):1095.

9.

Chapter 8. Activation mechanisms of chemokine receptors.

Jensen PC, Rosenkilde MM.

Methods Enzymol. 2009;461:171-90. doi: 10.1016/S0076-6879(09)05408-1.

PMID:
19480919
10.

Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.

Fox JM, Najarro P, Smith GL, Struyf S, Proost P, Pease JE.

J Biol Chem. 2006 Dec 1;281(48):36652-61. Epub 2006 Oct 5.

11.

Synthesis and in-vitro pharmacological evaluation of new 5-HT1A receptor ligands containing a benzotriazinone nucleus.

Fiorino F, Severino B, De Angelis F, Perissutti E, Frecentese F, Massarelli P, Bruni G, Collavoli E, Santagada V, Caliendo G.

Arch Pharm (Weinheim). 2008 Jan;341(1):20-7.

PMID:
18072244
12.

Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.

Hulshof JW, Casarosa P, Menge WM, Kuusisto LM, van der Goot H, Smit MJ, de Esch IJ, Leurs R.

J Med Chem. 2005 Oct 6;48(20):6461-71.

PMID:
16190772
13.

Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents.

Fiorino F, Magli E, Perissutti E, Severino B, Frecentese F, Esposito A, De Angelis F, Incisivo GM, Massarelli P, Nencini C, Di Gennaro E, Budillon A, Di Cintio A, Santagada V, Caliendo G.

Eur J Med Chem. 2011 Jun;46(6):2206-16. doi: 10.1016/j.ejmech.2011.03.001. Epub 2011 Mar 8.

PMID:
21440338
14.

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands.

Fang J, Akwabi-Ameyaw A, Britton JE, Katamreddy SR, Navas F 3rd, Miller AB, Williams SP, Gray DW, Orband-Miller LA, Shearin J, Heyer D.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5075-7. doi: 10.1016/j.bmcl.2008.07.121. Epub 2008 Aug 5.

PMID:
18722117
15.

Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.

Campiani G, Butini S, Trotta F, Fattorusso C, Catalanotti B, Aiello F, Gemma S, Nacci V, Novellino E, Stark JA, Cagnotto A, Fumagalli E, Carnovali F, Cervo L, Mennini T.

J Med Chem. 2003 Aug 28;46(18):3822-39.

PMID:
12930145
16.

Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.

Haskell CA, Horuk R, Liang M, Rosser M, Dunning L, Islam I, Kremer L, Gutiérrez J, Marquez G, Martinez-A C, Biscone MJ, Doms RW, Ribeiro S.

Mol Pharmacol. 2006 Jan;69(1):309-16. Epub 2005 Oct 12.

17.

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3.

Leclerc V, Ettaoussi M, Rami M, Farce A, Boutin JA, Delagrange P, Caignard DH, Renard P, Berthelot P, Yous S.

Eur J Med Chem. 2011 May;46(5):1622-9. doi: 10.1016/j.ejmech.2011.02.010. Epub 2011 Feb 15.

PMID:
21377769
18.

HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines.

Dairaghi DJ, Fan RA, McMaster BE, Hanley MR, Schall TJ.

J Biol Chem. 1999 Jul 30;274(31):21569-74.

19.

Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.

Zajdel P, Subra G, Bojarski AJ, Duszyńska B, Pawłowski M, Martinez J.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3406-10. Epub 2006 May 3.

PMID:
16677812
20.

De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.

Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ.

J Med Chem. 1998 Nov 19;41(24):4767-76.

PMID:
9822547
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