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Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis.

Czyzyk TA, Andrews JL, Coskun T, Wade MR, Hawkins ED, Lockwood JF, Varga G, Sahr AE, Chen Y, Brozinick JT, Kikly K, Statnick MA.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E282-92. doi: 10.1152/ajpendo.00228.2013. Epub 2013 May 28.


Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet.

Bjursell M, Admyre T, Göransson M, Marley AE, Smith DM, Oscarsson J, Bohlooly-Y M.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E211-20. doi: 10.1152/ajpendo.00229.2010. Epub 2010 Oct 19.


CTRP3 deficiency reduces liver size and alters IL-6 and TGFβ levels in obese mice.

Wolf RM, Lei X, Yang ZC, Nyandjo M, Tan SY, Wong GW.

Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E332-45. doi: 10.1152/ajpendo.00248.2015. Epub 2015 Dec 15.


Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice.

Sheng X, Wang M, Lu M, Xi B, Sheng H, Zang YQ.

Am J Physiol Endocrinol Metab. 2011 May;300(5):E886-93. doi: 10.1152/ajpendo.00332.2010. Epub 2011 Mar 1.


Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. doi: 10.2337/db08-0392. Epub 2008 Oct 7.


Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice.

Masaki T, Yoshimatsu H, Chiba S, Watanabe T, Sakata T.

Diabetes. 2001 Feb;50(2):376-84.


Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation.

Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P.

Diabetes. 2007 Oct;56(10):2523-32. Epub 2007 Jul 23.


Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.

Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL.

Mol Cell Biochem. 2006 Apr;285(1-2):35-50. Epub 2006 Feb 14.


Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.

Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, Yang L, Wang T, Hong S, Guo S, She ZG, Zhang XD, Li H.

Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E485-95. doi: 10.1152/ajpendo.00505.2012. Epub 2013 May 21.


Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

Perez-Sieira S, Martinez G, Porteiro B, Lopez M, Vidal A, Nogueiras R, Dieguez C.

PLoS One. 2013;8(1):e53836. doi: 10.1371/journal.pone.0053836. Epub 2013 Jan 14.


Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism.

Santos SH, Fernandes LR, Mario EG, Ferreira AV, Pôrto LC, Alvarez-Leite JI, Botion LM, Bader M, Alenina N, Santos RA.

Diabetes. 2008 Feb;57(2):340-7. Epub 2007 Nov 19.


Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity.

Paula GS, Souza LL, Cabanelas A, Bloise FF, Mello-Coelho V, Wada E, Ortiga-Carvalho TM, Oliveira KJ, Pazos-Moura CC.

J Physiol. 2010 May 1;588(Pt 9):1635-45. doi: 10.1113/jphysiol.2009.185322. Epub 2010 Mar 8.


Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.

Peyrou M, Bourgoin L, Poher AL, Altirriba J, Maeder C, Caillon A, Fournier M, Montet X, Rohner-Jeanrenaud F, Foti M.

J Hepatol. 2015 Feb;62(2):421-9. doi: 10.1016/j.jhep.2014.09.012. Epub 2014 Sep 16.


Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice.

Kusakabe T, Ebihara K, Sakai T, Miyamoto L, Aotani D, Yamamoto Y, Yamamoto-Kataoka S, Aizawa-Abe M, Fujikura J, Hosoda K, Nakao K.

Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E924-31. doi: 10.1152/ajpendo.00198.2011. Epub 2012 Jan 24.


Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ.

J Biol Chem. 2012 Apr 6;287(15):12578-88. doi: 10.1074/jbc.M111.309559. Epub 2012 Feb 23.


GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice.

Tomas E, Wood JA, Stanojevic V, Habener JF.

Regul Pept. 2011 Aug 8;169(1-3):43-8. doi: 10.1016/j.regpep.2011.04.006. Epub 2011 May 4.


Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake.

Gao XF, Chen W, Kong XP, Xu AM, Wang ZG, Sweeney G, Wu D.

Diabetologia. 2009 May;52(5):912-20. doi: 10.1007/s00125-009-1284-0. Epub 2009 Feb 18.


Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.

Jeong JK, Szabo G, Raso GM, Meli R, Diano S.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1502-10. doi: 10.1152/ajpendo.00544.2011. Epub 2012 Mar 27.


Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia.

Lutz SZ, Hennige AM, Feil S, Peter A, Gerling A, Machann J, Kröber SM, Rath M, Schürmann A, Weigert C, Häring HU, Feil R.

Diabetes. 2011 May;60(5):1566-76. doi: 10.2337/db10-0760. Epub 2011 Apr 4.

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