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Items: 1 to 20 of 115


Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.

Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D, Zheng H.

Nat Cell Biol. 2013 Jul;15(7):829-38. doi: 10.1038/ncb2765. Epub 2013 May 26.


Sequential addition of reprogramming factors improves efficiency.

Gaeta X, Xie Y, Lowry WE.

Nat Cell Biol. 2013 Jul;15(7):725-7. doi: 10.1038/ncb2800.


Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells.

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Schöler HR, Schambach A, Cantz T.

Cytometry A. 2011 Jun;79(6):426-35. doi: 10.1002/cyto.a.21072. Epub 2011 May 4.


A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.

Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D.

Cell Stem Cell. 2010 Jul 2;7(1):51-63. doi: 10.1016/j.stem.2010.04.014. Epub 2010 Jun 17.


Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.

Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H.

Cell Res. 2011 Jan;21(1):196-204. doi: 10.1038/cr.2010.142. Epub 2010 Oct 19.


Oct4-enhanced green fluorescent protein transgenic pigs: a new large animal model for reprogramming studies.

Nowak-Imialek M, Kues WA, Petersen B, Lucas-Hahn A, Herrmann D, Haridoss S, Oropeza M, Lemme E, Schöler HR, Carnwath JW, Niemann H.

Stem Cells Dev. 2011 Sep;20(9):1563-75. doi: 10.1089/scd.2010.0399. Epub 2011 Jan 12.


Direct reprogramming of fibroblasts into epiblast stem cells.

Han DW, Greber B, Wu G, Tapia N, Araúzo-Bravo MJ, Ko K, Bernemann C, Stehling M, Schöler HR.

Nat Cell Biol. 2011 Jan;13(1):66-71. doi: 10.1038/ncb2136. Epub 2010 Dec 5.


Gata4 blocks somatic cell reprogramming by directly repressing Nanog.

Serrano F, Calatayud CF, Blazquez M, Torres J, Castell JV, Bort R.

Stem Cells. 2013 Jan;31(1):71-82. doi: 10.1002/stem.1272.


C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, Graf T.

Nature. 2014 Feb 13;506(7487):235-9. doi: 10.1038/nature12885. Epub 2013 Dec 15.


c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells.

Martinez-Fernandez A, Nelson TJ, Ikeda Y, Terzic A.

J Cardiovasc Transl Res. 2010 Feb;3(1):13-23. doi: 10.1007/s12265-009-9150-5.


Manipulation of KLF4 expression generates iPSCs paused at successive stages of reprogramming.

Nishimura K, Kato T, Chen C, Oinam L, Shiomitsu E, Ayakawa D, Ohtaka M, Fukuda A, Nakanishi M, Hisatake K.

Stem Cell Reports. 2014 Nov 11;3(5):915-29. doi: 10.1016/j.stemcr.2014.08.014. Epub 2014 Oct 2.


Two-phase analysis of molecular pathways underlying induced pluripotent stem cell induction.

Lin Z, Perez P, Lei D, Xu J, Gao X, Bao J.

Stem Cells. 2011 Dec;29(12):1963-74. doi: 10.1002/stem.752.


Activation of pluripotency-associated genes in mouse embryonic fibroblasts by non-viral transfection with in vitro-derived mRNAs encoding Oct4, Sox2, Klf4 and cMyc.

Tavernier G, Wolfrum K, Demeester J, De Smedt SC, Adjaye J, Rejman J.

Biomaterials. 2012 Jan;33(2):412-7. doi: 10.1016/j.biomaterials.2011.09.062. Epub 2011 Oct 10.


Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells.

Li HY, Chien Y, Chen YJ, Chen SF, Chang YL, Chiang CH, Jeng SY, Chang CM, Wang ML, Chen LK, Hung SI, Huo TI, Lee SD, Chiou SH.

Biomaterials. 2011 Sep;32(26):5994-6005. doi: 10.1016/j.biomaterials.2011.05.009. Epub 2011 Jun 11.


Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation.

Wang G, Guo X, Hong W, Liu Q, Wei T, Lu C, Gao L, Ye D, Zhou Y, Chen J, Wang J, Wu M, Liu H, Kang J.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2858-63. doi: 10.1073/pnas.1212769110. Epub 2013 Feb 5.


Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming.

Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, Chen X, Bai G, Liu C, Pera M, Lu W.

Stem Cells. 2009 Dec;27(12):2969-78. doi: 10.1002/stem.231.


The timing of retroviral silencing correlates with the quality of induced pluripotent stem cell lines.

Okada M, Yoneda Y.

Biochim Biophys Acta. 2011 Feb;1810(2):226-35. doi: 10.1016/j.bbagen.2010.10.004. Epub 2010 Oct 20.


Using small molecules to improve generation of induced pluripotent stem cells from somatic cells.

Desponts C, Ding S.

Methods Mol Biol. 2010;636:207-18. doi: 10.1007/978-1-60761-691-7_13.


BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone.

Chen J, Liu J, Yang J, Chen Y, Chen J, Ni S, Song H, Zeng L, Ding K, Pei D.

Cell Res. 2011 Jan;21(1):205-12. doi: 10.1038/cr.2010.172. Epub 2010 Dec 7.


Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network.

Mah N, Wang Y, Liao MC, Prigione A, Jozefczuk J, Lichtner B, Wolfrum K, Haltmeier M, Flöttmann M, Schaefer M, Hahn A, Mrowka R, Klipp E, Andrade-Navarro MA, Adjaye J.

PLoS One. 2011;6(8):e24351. doi: 10.1371/journal.pone.0024351. Epub 2011 Aug 31.

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