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18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells.

Fu XX, Du LL, Zhao N, Dong Q, Liao YH, Du YM.

J Ethnopharmacol. 2013 Jul 9;148(2):647-54. doi: 10.1016/j.jep.2013.05.022. Epub 2013 May 21.


Acacetin blocks kv1.3 channels and inhibits human T cell activation.

Zhao N, Dong Q, Fu XX, Du LL, Cheng X, Du YM, Liao YH.

Cell Physiol Biochem. 2014;34(4):1359-72. doi: 10.1159/000366343. Epub 2014 Oct 2.


18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.

Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH.

Acta Pharmacol Sin. 2012 Jun;33(6):752-60. doi: 10.1038/aps.2012.22. Epub 2012 May 21.


Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.

Zhao N, Dong Q, Du LL, Fu XX, Du YM, Liao YH.

PLoS One. 2013 May 22;8(5):e64629. doi: 10.1371/journal.pone.0064629. Print 2013.


Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation.

Beeton C, Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Béraud E.

J Immunol. 2001 Jan 15;166(2):936-44.


Glycyrretinic acid blocks cardiac sodium channels expressed in Xenopus oocytes.

Du Y, Zhang S, Wu H, Zou A, Lei M, Cheng L, Liao Y.

J Ethnopharmacol. 2009 Sep 7;125(2):318-23. doi: 10.1016/j.jep.2009.06.016. Epub 2009 Jun 25.


18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha.

Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y, Zhang Y.

J Biol Chem. 2010 Jan 8;285(2):1128-37. doi: 10.1074/jbc.M109.037705. Epub 2009 Nov 6.


The influence of 8-prenylnaringenin on the activity of voltage-gated Kv1.3 potassium channels in human Jurkat T cells.

Gąsiorowska J, Teisseyre A, Uryga A, Michalak K.

Cell Mol Biol Lett. 2012 Dec;17(4):559-70. Epub 2012 Aug 29.


18β-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer.

Huang RY, Chu YL, Huang QC, Chen XM, Jiang ZB, Zhang X, Zeng X.

PLoS One. 2014 Apr 2;9(4):e93690. doi: 10.1371/journal.pone.0093690. eCollection 2014.


18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.

Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P.

J Periodontal Res. 2010 Dec;45(6):757-63. doi: 10.1111/j.1600-0765.2010.01296.x.


Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region.

Yang W, Feng J, Xiang F, Xie Z, Zhang G, Sabatier JM, Cao Z, Li W, Chen Z, Wu Y.

Cell Mol Life Sci. 2015 Feb;72(4):845-53. doi: 10.1007/s00018-014-1715-z. Epub 2014 Sep 20.


Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines.

Feng Yeh C, Wang KC, Chiang LC, Shieh DE, Yen MH, San Chang J.

J Ethnopharmacol. 2013 Jul 9;148(2):466-73. doi: 10.1016/j.jep.2013.04.040. Epub 2013 Apr 30.


18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity.

Park M, Lee JH, Choi JK, Hong YD, Bae IH, Lim KM, Park YH, Ha H.

Mol Nutr Food Res. 2014 Jul;58(7):1436-46. doi: 10.1002/mnfr.201300763. Epub 2014 Mar 31.


Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.

Wang CY, Kao TC, Lo WH, Yen GC.

J Agric Food Chem. 2011 Jul 27;59(14):7726-33. doi: 10.1021/jf2013265. Epub 2011 Jun 24.


Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO.

PLoS One. 2008;3(12):e4009. doi: 10.1371/journal.pone.0004009. Epub 2008 Dec 23.


Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels.

Villalonga N, David M, Bielańska J, González T, Parra D, Soler C, Comes N, Valenzuela C, Felipe A.

Biochem Pharmacol. 2010 Sep 15;80(6):858-66. doi: 10.1016/j.bcp.2010.05.012. Epub 2010 May 19.


T-lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in the neonate.

Toldi G, Treszl A, Pongor V, Gyarmati B, Tulassay T, Vásárhelyi B.

Int Immunol. 2010 Sep;22(9):769-74. doi: 10.1093/intimm/dxq063. Epub 2010 Jul 2.


Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1alpha in Jurkat T cells.

Matsushita Y, Ohya S, Suzuki Y, Itoda H, Kimura T, Yamamura H, Imaizumi Y.

Am J Physiol Cell Physiol. 2009 May;296(5):C1079-85. doi: 10.1152/ajpcell.00668.2008. Epub 2009 Mar 18.


The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis.

Toldi G, Bajnok A, Dobi D, Kaposi A, Kovács L, Vásárhelyi B, Balog A.

Immunobiology. 2013 Mar;218(3):311-6. doi: 10.1016/j.imbio.2012.05.013. Epub 2012 May 23.


Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation.

Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich AH.

J Immunol. 2003 Jan 15;170(2):695-702.

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