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Results: 1 to 20 of 118

1.

Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

Liang LP, Kavanagh TJ, Patel M.

Toxicol Sci. 2013 Aug;134(2):366-73. doi: 10.1093/toxsci/kft112. Epub 2013 May 23.

PMID:
23704229
[PubMed - indexed for MEDLINE]
2.

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.

McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, Cory-Slechta DA, Di Monte DA.

Neurobiol Dis. 2002 Jul;10(2):119-27.

PMID:
12127150
[PubMed - indexed for MEDLINE]
3.

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.

Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP.

J Biol Chem. 2002 Dec 20;277(51):49446-52. Epub 2002 Oct 15.

PMID:
12384496
[PubMed - indexed for MEDLINE]
Free Article
4.

Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease.

Chinta SJ, Andersen JK.

Free Radic Biol Med. 2006 Nov 1;41(9):1442-8. Epub 2006 Aug 7.

PMID:
17023271
[PubMed - indexed for MEDLINE]
5.

Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice.

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV.

Neurotoxicol Teratol. 2012 Jul;34(4):450-7. doi: 10.1016/j.ntt.2012.04.009. Epub 2012 May 10.

PMID:
22580179
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective.

Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U.

Toxicol Lett. 2013 Nov 25;223(2):260-7. doi: 10.1016/j.toxlet.2013.09.017. Epub 2013 Oct 6.

PMID:
24107266
[PubMed - indexed for MEDLINE]
7.

Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.

Nakamura BN, Mohar I, Lawson GW, Cort├ęs MM, Hoang YD, Ortiz L, Patel R, Rau BA, McConnachie LA, Kavanagh TJ, Luderer U.

Toxicol Sci. 2012 Mar;126(1):227-41. doi: 10.1093/toxsci/kfs017. Epub 2012 Jan 17.

PMID:
22253057
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart.

Watanabe Y, Watanabe K, Kobayashi T, Saito Y, Fujioka D, Nakamura T, Obata JE, Kawabata K, Mishina H, Kugiyama K.

Cardiovasc Res. 2013 Feb 1;97(2):282-92. doi: 10.1093/cvr/cvs333. Epub 2012 Nov 5.

PMID:
23129588
[PubMed - indexed for MEDLINE]
Free Article
9.

Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice.

Weldy CS, Luttrell IP, White CC, Morgan-Stevenson V, Bammler TK, Beyer RP, Afsharinejad Z, Kim F, Chitaley K, Kavanagh TJ.

Free Radic Biol Med. 2012 Sep 15;53(6):1264-78. doi: 10.1016/j.freeradbiomed.2012.07.006. Epub 2012 Jul 21.

PMID:
22824862
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: similarity with paraquat neurotoxicity.

Kumar A, Singh BK, Ahmad I, Shukla S, Patel DK, Srivastava G, Kumar V, Pandey HP, Singh C.

Brain Res. 2012 Feb 15;1438:48-64. doi: 10.1016/j.brainres.2011.12.028. Epub 2011 Dec 20.

PMID:
22244881
[PubMed - indexed for MEDLINE]
11.

Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

McCormack AL, Atienza JG, Johnston LC, Andersen JK, Vu S, Di Monte DA.

J Neurochem. 2005 May;93(4):1030-7.

PMID:
15857406
[PubMed - indexed for MEDLINE]
12.

Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.

Nakamura BN, Fielder TJ, Hoang YD, Lim J, McConnachie LA, Kavanagh TJ, Luderer U.

Endocrinology. 2011 Jul;152(7):2806-15. doi: 10.1210/en.2011-0207. Epub 2011 May 10.

PMID:
21558310
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW.

Biochem Biophys Res Commun. 2000 Dec 20;279(2):324-9.

PMID:
11118286
[PubMed - indexed for MEDLINE]
14.

Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis.

Chen Y, Krishan M, Nebert DW, Shertzer HG.

Chem Res Toxicol. 2012 Jan 13;25(1):94-100. doi: 10.1021/tx200242a. Epub 2011 Dec 6.

PMID:
22082335
[PubMed - indexed for MEDLINE]
15.

Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice.

Kang MJ, Gil SJ, Koh HC.

Toxicol Lett. 2009 Jul 24;188(2):148-52. doi: 10.1016/j.toxlet.2009.03.026. Epub 2009 Apr 5.

PMID:
19446248
[PubMed - indexed for MEDLINE]
16.

The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis.

Yang W, Tiffany-Castiglioni E.

J Toxicol Environ Health A. 2005 Nov 26;68(22):1939-61.

PMID:
16263688
[PubMed - indexed for MEDLINE]
17.

Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.

Thiruchelvam M, McCormack A, Richfield EK, Baggs RB, Tank AW, Di Monte DA, Cory-Slechta DA.

Eur J Neurosci. 2003 Aug;18(3):589-600.

PMID:
12911755
[PubMed - indexed for MEDLINE]
18.

Toxic influence of chronic oral administration of paraquat on nigrostriatal dopaminergic neurons in C57BL/6 mice.

Ren JP, Zhao YW, Sun XJ.

Chin Med J (Engl). 2009 Oct 5;122(19):2366-71.

PMID:
20079141
[PubMed - indexed for MEDLINE]
Free Article
19.

Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP.

J Biol Chem. 2005 Oct 7;280(40):33766-74. Epub 2005 Aug 4.

PMID:
16081425
[PubMed - indexed for MEDLINE]
Free Article
20.

Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder.

Kulak A, Cuenod M, Do KQ.

Behav Brain Res. 2012 Jan 15;226(2):563-70. doi: 10.1016/j.bbr.2011.10.020. Epub 2011 Oct 20.

PMID:
22033334
[PubMed - indexed for MEDLINE]

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