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Items: 1 to 20 of 127

1.

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Neuhoff S, Yeo KR, Barter Z, Jamei M, Turner DB, Rostami-Hodjegan A.

J Pharm Sci. 2013 Sep;102(9):3145-60. doi: 10.1002/jps.23594. Epub 2013 May 22.

PMID:
23703021
2.

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

Neuhoff S, Yeo KR, Barter Z, Jamei M, Turner DB, Rostami-Hodjegan A.

J Pharm Sci. 2013 Sep;102(9):3161-73. doi: 10.1002/jps.23607. Epub 2013 May 19.

PMID:
23686764
5.

Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Elsby R, Baluom M, Lau D, Mant T.

Clin Ther. 2015 Dec 1;37(12):2811-22. doi: 10.1016/j.clinthera.2015.09.018. Epub 2015 Oct 26.

PMID:
26514315
6.

Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions.

Greupink R, Schreurs M, Benne MS, Huisman MT, Russel FG.

Eur J Pharm Sci. 2013 Aug 16;49(5):819-28. doi: 10.1016/j.ejps.2013.06.009. Epub 2013 Jun 24.

PMID:
23806476
7.

In vitro to in vivo comparison of the substrate characteristics of sorafenib tosylate toward P-glycoprotein.

Gnoth MJ, Sandmann S, Engel K, Radtke M.

Drug Metab Dispos. 2010 Aug;38(8):1341-6. doi: 10.1124/dmd.110.032052. Epub 2010 Apr 22.

8.
9.

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Liu PQ, Duan W, Chowbay B, Wen JY, Li CG, Zhou SF.

Curr Drug Metab. 2007 May;8(4):325-40.

PMID:
17504222
10.

Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.

Estudante M, Maya M, Morais JG, Soveral G, Benet LZ.

Mol Pharm. 2013 Nov 4;10(11):4038-45. doi: 10.1021/mp400381p. Epub 2013 Sep 27.

PMID:
24044638
11.

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats.

Zhang H, Yao M, Morrison RA, Chong S.

Arch Pharm Res. 2003 Sep;26(9):768-72.

PMID:
14560928
12.

The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.

Elsby R, Gillen M, Butters C, Imisson G, Sharma P, Smith V, Surry DD.

Drug Metab Dispos. 2011 Feb;39(2):275-82. doi: 10.1124/dmd.110.035881. Epub 2010 Nov 12.

13.
14.

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.

Tubic M, Wagner D, Spahn-Langguth H, Bolger MB, Langguth P.

Pharm Res. 2006 Aug;23(8):1712-20.

PMID:
16832615
16.

A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug-drug interactions.

Guo H, Liu C, Li J, Zhang M, Hu M, Xu P, Liu L, Liu X.

J Pharm Sci. 2013 Aug;102(8):2819-36. doi: 10.1002/jps.23613. Epub 2013 Jun 11.

PMID:
23760985
17.

P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies.

Yang C, Zhang T, Li Z, Xu L, Liu F, Ruan J, Liu K, Zhang Z.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):561-8. doi: 10.1016/j.taap.2013.09.030. Epub 2013 Oct 9.

PMID:
24120885
19.

Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux.

Igel S, Drescher S, Mürdter T, Hofmann U, Heinkele G, Tegude H, Glaeser H, Brenner SS, Somogyi AA, Omari T, Schäfer C, Eichelbaum M, Fromm MF.

Clin Pharmacokinet. 2007;46(9):777-85.

PMID:
17713975
20.

P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.

Oga EF, Sekine S, Shitara Y, Horie T.

J Ethnopharmacol. 2012 Dec 18;144(3):612-7. doi: 10.1016/j.jep.2012.10.001. Epub 2012 Oct 11.

PMID:
23064285
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