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Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells.

Ormazabal P, Romero C, Quest AF, Vega M.

Horm Metab Res. 2013 Sep;45(9):640-5. doi: 10.1055/s-0033-1345176. Epub 2013 May 22.


Decreased phosphorylation of Y¹⁴caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may be related with an insulin resistant state in this tissue.

Ormazabal P, Romero C, Gabler F, Quest AF, Vega M.

Horm Metab Res. 2013 Apr;45(4):291-6. doi: 10.1055/s-0032-1329972. Epub 2012 Dec 7. Erratum in: Horm Metab Res. 2013 Apr;45(4):e2.


Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS).

Rivero R, Garin CA, Ormazabal P, Silva A, Carvajal R, Gabler F, Romero C, Vega M.

Reprod Biol Endocrinol. 2012 Mar 5;10:17. doi: 10.1186/1477-7827-10-17.


Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients.

Carvajal R, Rosas C, Kohan K, Gabler F, Vantman D, Romero C, Vega M.

Hum Reprod. 2013 Aug;28(8):2235-44. doi: 10.1093/humrep/det116. Epub 2013 Apr 17.


[Activation and significance of the PI3K/Akt pathway in endometrium with polycystic ovary syndrome patients].

Zhang HY, Zhang YF, Han YK, Xue FX, Zhao XH, Zhang XL.

Zhonghua Fu Chan Ke Za Zhi. 2012 Jan;47(1):19-23. Chinese.


Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia.

Fornes R, Ormazabal P, Rosas C, Gabler F, Vantman D, Romero C, Vega M.

Mol Med. 2010 Mar;16(3-4):129-36. doi: 10.2119/molmed.2009.00118. Epub 2009 Dec 4.


Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues.

Nada SE, Thompson RC, Padmanabhan V.

Endocrinology. 2010 Nov;151(11):5165-73. doi: 10.1210/en.2010-0666. Epub 2010 Sep 15.


Over-expression of LYRM1 inhibits glucose transport in rat skeletal muscles via attenuated phosphorylation of PI3K (p85) and Akt.

Kou C, Cao X, Qin D, Ji C, Zhu J, Zhang C, Zhu C, Gao C, Chen R, Guo X, Zhang M.

Mol Cell Biochem. 2011 Feb;348(1-2):149-54. doi: 10.1007/s11010-010-0649-5. Epub 2010 Nov 12.


Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin.

Ferreira GD, Germeyer A, de Barros Machado A, do Nascimento TL, Strowitzki T, Brum IS, von Eye Corleta H, Capp E.

Eur J Obstet Gynecol Reprod Biol. 2014 Apr;175:157-62. doi: 10.1016/j.ejogrb.2014.01.009. Epub 2014 Jan 15.


The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.

Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R.

J Biol Chem. 2005 Nov 11;280(45):37393-9. Epub 2005 Aug 29.


High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.

Venieratos PD, Drossopoulou GI, Kapodistria KD, Tsilibary EC, Kitsiou PV.

Cell Signal. 2010 May;22(5):791-800. doi: 10.1016/j.cellsig.2010.01.003. Epub 2010 Jan 11.


TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells.

del Aguila LF, Claffey KP, Kirwan JP.

Am J Physiol. 1999 May;276(5 Pt 1):E849-55.


Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.

Kwon H, Lee J, Jeong K, Jang D, Pak Y.

Biochim Biophys Acta. 2015 May;1853(5):1022-34. doi: 10.1016/j.bbamcr.2015.02.002. Epub 2015 Feb 7.


High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling.

Gómez-Ruiz A, Milagro FI, Campión J, Martínez JA, de Miguel C.

Lipids Health Dis. 2011 Apr 13;10:55. doi: 10.1186/1476-511X-10-55.


Continually high insulin levels impair Akt phosphorylation and glucose transport in human myoblasts.

Bertacca A, Ciccarone A, Cecchetti P, Vianello B, Laurenza I, Maffei M, Chiellini C, Del Prato S, Benzi L.

Metabolism. 2005 Dec;54(12):1687-93.


Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.

Panariello F, Perruolo G, Cassese A, Giacco F, Botta G, Barbagallo AP, Muscettola G, Beguinot F, Formisano P, de Bartolomeis A.

J Cell Physiol. 2012 Apr;227(4):1485-92. doi: 10.1002/jcp.22864.

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