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Items: 1 to 20 of 142

1.

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution.

Chytil P, Hoffmann S, Schindler L, Kostka L, Ulbrich K, Caysa H, Mueller T, Mäder K, Etrych T.

J Control Release. 2013 Dec 10;172(2):504-12. doi: 10.1016/j.jconrel.2013.05.008. Epub 2013 May 19.

PMID:
23697767
2.

Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging.

Hoffmann S, Vystrčilová L, Ulbrich K, Etrych T, Caysa H, Mueller T, Mäder K.

Biomacromolecules. 2012 Mar 12;13(3):652-63. doi: 10.1021/bm2015027. Epub 2012 Feb 10.

PMID:
22263698
3.
4.

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting.

Etrych T, Chytil P, Mrkvan T, Sírová M, Ríhová B, Ulbrich K.

J Control Release. 2008 Dec 18;132(3):184-92. doi: 10.1016/j.jconrel.2008.04.017. Epub 2008 Apr 29.

PMID:
18534705
5.

Novel star HPMA-based polymer conjugates for passive targeting to solid tumors.

Etrych T, Strohalm J, Chytil P, Říhová B, Ulbrich K.

J Drug Target. 2011 Dec;19(10):874-89. doi: 10.3109/1061186X.2011.622402. Epub 2011 Oct 6.

PMID:
21978286
6.

Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles.

Zhou Z, Li L, Yang Y, Xu X, Huang Y.

Biomaterials. 2014 Aug;35(24):6622-35. doi: 10.1016/j.biomaterials.2014.04.059. Epub 2014 May 10.

PMID:
24814427
7.

Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.

Etrych T, Kovář L, Strohalm J, Chytil P, Ríhová B, Ulbrich K.

J Control Release. 2011 Sep 25;154(3):241-8. doi: 10.1016/j.jconrel.2011.06.015. Epub 2011 Jun 15.

PMID:
21699933
8.

HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity.

Etrych T, Strohalm J, Kovár L, Kabesová M, Ríhová B, Ulbrich K.

J Control Release. 2009 Nov 16;140(1):18-26. doi: 10.1016/j.jconrel.2009.07.011. Epub 2009 Jul 24.

PMID:
19632282
9.

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.

Etrych T, Jelínková M, Ríhová B, Ulbrich K.

J Control Release. 2001 May 18;73(1):89-102.

PMID:
11337062
10.

Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours.

Etrych T, Subr V, Laga R, Ríhová B, Ulbrich K.

Eur J Pharm Sci. 2014 Jul 16;58:1-12. doi: 10.1016/j.ejps.2014.02.016. Epub 2014 Mar 13.

PMID:
24632485
11.

Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging.

Shi Y, Kunjachan S, Wu Z, Gremse F, Moeckel D, van Zandvoort M, Kiessling F, Storm G, van Nostrum CF, Hennink WE, Lammers T.

Nanomedicine (Lond). 2015;10(7):1111-25. doi: 10.2217/nnm.14.170.

12.

HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.

Etrych T, Sírová M, Starovoytova L, Ríhová B, Ulbrich K.

Mol Pharm. 2010 Aug 2;7(4):1015-26. doi: 10.1021/mp100119f.

PMID:
20518512
13.

Synthesis and Properties of Star HPMA Copolymer Nanocarriers Synthesised by RAFT Polymerisation Designed for Selective Anticancer Drug Delivery and Imaging.

Chytil P, Koziolová E, Janoušková O, Kostka L, Ulbrich K, Etrych T.

Macromol Biosci. 2015 Jun;15(6):839-50. doi: 10.1002/mabi.201400510. Epub 2015 Mar 2.

PMID:
25731143
14.

HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity.

Ulbrich K, Etrych T, Chytil P, Jelínková M, Ríhová B.

J Control Release. 2003 Feb 21;87(1-3):33-47.

PMID:
12618021
15.

Biodegradable micellar HPMA-based polymer-drug conjugates with betulinic acid for passive tumor targeting.

Lomkova EA, Chytil P, Janoušková O, Mueller T, Lucas H, Filippov SK, Trhlíková O, Aleshunin PA, Skorik YA, Ulbrich K, Etrych T.

Biomacromolecules. 2016 Sep 16. [Epub ahead of print]

PMID:
27636143
16.

HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity.

Etrych T, Subr V, Strohalm J, Sírová M, Ríhová B, Ulbrich K.

J Control Release. 2012 Dec 28;164(3):346-54. doi: 10.1016/j.jconrel.2012.06.029. Epub 2012 Jun 30.

PMID:
22759979
17.

Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery.

Borgman MP, Aras O, Geyser-Stoops S, Sausville EA, Ghandehari H.

Mol Pharm. 2009 Nov-Dec;6(6):1836-47. doi: 10.1021/mp900134c.

18.

Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates.

Line BR, Mitra A, Nan A, Ghandehari H.

J Nucl Med. 2005 Sep;46(9):1552-60.

19.

Hydrolytically degradable polymer micelles for drug delivery: a SAXS/SANS kinetic study.

Filippov SK, Franklin JM, Konarev PV, Chytil P, Etrych T, Bogomolova A, Dyakonova M, Papadakis CM, Radulescu A, Ulbrich K, Stepanek P, Svergun DI.

Biomacromolecules. 2013 Nov 11;14(11):4061-70. doi: 10.1021/bm401186z. Epub 2013 Oct 25.

PMID:
24083567
20.

Improvement of anti-tumor abilities on human non-small cell lung carcinoma by micellization and cross-linking of N-(2-hydroxypropyl) methacrylamide copolymers.

Zhou Z, Xu X, Li L, Huang Y.

J Drug Target. 2015;23(9):821-31. doi: 10.3109/1061186X.2015.1025076. Epub 2015 Apr 1.

PMID:
25830626
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