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Items: 1 to 20 of 102


Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD.

Chen Y, Tascón I, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A.

PLoS Pathog. 2013;9(5):e1003382. doi: 10.1371/journal.ppat.1003382. Epub 2013 May 16. Erratum in: PLoS Pathog. 2013;9(7). doi:10.1371/annotation/2b8e6418-2496-4ffb-b230-95d90b748086.


De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila.

Neunuebel MR, Chen Y, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP.

Science. 2011 Jul 22;333(6041):453-6. doi: 10.1126/science.1207193. Epub 2011 Jun 16.


Identification and modelling of a PPM protein phosphatase fold in the Legionella pneumophila deAMPylase SidD.

Rigden DJ.

FEBS Lett. 2011 Sep 2;585(17):2749-54. doi: 10.1016/j.febslet.2011.08.006. Epub 2011 Aug 11.


De-AMPylation unmasked: modulation of host membrane trafficking.

Ham H, Orth K.

Sci Signal. 2011 Oct 11;4(194):pe42. doi: 10.1126/scisignal.2002458. Review.


AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila.

Hardiman CA, Roy CR.

MBio. 2014 Feb 11;5(1):e01035-13. doi: 10.1128/mBio.01035-13.


The taming of a Rab GTPase by Legionella pneumophila.

Neunuebel MR, Machner MP.

Small GTPases. 2012 Jan-Mar;3(1):28-33. doi: 10.4161/sgtp.18704.


Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein.

Müller MP, Shkumatov AV, Oesterlin LK, Schoebel S, Goody PR, Goody RS, Itzen A.

J Biol Chem. 2012 Oct 12;287(42):35036-46. doi: 10.1074/jbc.M112.396861. Epub 2012 Aug 7.


Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1.

Neunuebel MR, Mohammadi S, Jarnik M, Machner MP.

J Bacteriol. 2012 Mar;194(6):1389-400. doi: 10.1128/JB.06306-11. Epub 2012 Jan 6.


Legionella pneumophila SidD is a deAMPylase that modifies Rab1.

Tan Y, Luo ZQ.

Nature. 2011 Jul 6;475(7357):506-9. doi: 10.1038/nature10307.


Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.

Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4699-704. doi: 10.1073/pnas.0914231107. Epub 2010 Feb 22.


The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.

Müller MP, Peters H, Blümer J, Blankenfeldt W, Goody RS, Itzen A.

Science. 2010 Aug 20;329(5994):946-9. doi: 10.1126/science.1192276. Epub 2010 Jul 22.


Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.

Mihai Gazdag E, Streller A, Haneburger I, Hilbi H, Vetter IR, Goody RS, Itzen A.

EMBO Rep. 2013 Feb;14(2):199-205. doi: 10.1038/embor.2012.211. Epub 2013 Jan 4.


Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5.

Lucas M, Gaspar AH, Pallara C, Rojas AL, Fernández-Recio J, Machner MP, Hierro A.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3514-23. doi: 10.1073/pnas.1405391111. Epub 2014 Aug 11.


The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.

Murata T, Delprato A, Ingmundson A, Toomre DK, Lambright DG, Roy CR.

Nat Cell Biol. 2006 Sep;8(9):971-7. Epub 2006 Aug 13.


Efficient synthesis and applications of peptides containing adenylylated tyrosine residues.

Smit C, Blümer J, Eerland MF, Albers MF, Müller MP, Goody RS, Itzen A, Hedberg C.

Angew Chem Int Ed Engl. 2011 Sep 19;50(39):9200-4. doi: 10.1002/anie.201103203. Epub 2011 Aug 25. No abstract available.


Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

Brombacher E, Urwyler S, Ragaz C, Weber SS, Kami K, Overduin M, Hilbi H.

J Biol Chem. 2009 Feb 20;284(8):4846-56. doi: 10.1074/jbc.M807505200. Epub 2008 Dec 17.


RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity.

Schoebel S, Oesterlin LK, Blankenfeldt W, Goody RS, Itzen A.

Mol Cell. 2009 Dec 25;36(6):1060-72. doi: 10.1016/j.molcel.2009.11.014.


Legionella pneumophila proteins that regulate Rab1 membrane cycling.

Ingmundson A, Delprato A, Lambright DG, Roy CR.

Nature. 2007 Nov 15;450(7168):365-9. Epub 2007 Oct 21.


Structural insights into a unique Legionella pneumophila effector LidA recognizing both GDP and GTP bound Rab1 in their active state.

Cheng W, Yin K, Lu D, Li B, Zhu D, Chen Y, Zhang H, Xu S, Chai J, Gu L.

PLoS Pathog. 2012;8(3):e1002528. doi: 10.1371/journal.ppat.1002528. Epub 2012 Mar 1.

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