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Results: 1 to 20 of 87

Similar articles for PubMed (Select 23692872)

1.

Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.

Mazurov AA, Kombo DC, Akireddy S, Murthy S, Hauser TA, Jordan KG, Gatto GJ, Yohannes D.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3927-34. doi: 10.1016/j.bmcl.2013.04.058. Epub 2013 May 1.

PMID:
23692872
2.

Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.

Scanio MJ, Shi L, Bunnelle WH, Anderson DJ, Helfrich RJ, Malysz J, Thorin-Hagene KK, Van Handel CE, Marsh KC, Lee CH, Gopalakrishnan M.

J Med Chem. 2011 Nov 10;54(21):7678-92. doi: 10.1021/jm201045m. Epub 2011 Oct 11.

PMID:
21962147
3.

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.

Mazurov AA, Miao L, Bhatti BS, Strachan JP, Akireddy S, Murthy S, Kombo D, Xiao YD, Hammond P, Zhang J, Hauser TA, Jordan KG, Miller CH, Speake JD, Gatto GJ, Yohannes D.

J Med Chem. 2012 Nov 8;55(21):9181-94. doi: 10.1021/jm3006542. Epub 2012 Jul 27.

PMID:
22793665
4.

Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.

Blum AP, Lester HA, Dougherty DA.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13206-11. doi: 10.1073/pnas.1007140107. Epub 2010 Jun 28.

5.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.

Eibl C, Tomassoli I, Munoz L, Stokes C, Papke RL, Gündisch D.

Bioorg Med Chem. 2013 Dec 1;21(23):7283-308. doi: 10.1016/j.bmc.2013.09.059. Epub 2013 Oct 5.

PMID:
24156938
6.

Computational studies of novel carbonyl-containing diazabicyclic ligands interacting with α4β2 nicotinic acetylcholine receptor (nAChR) reveal alternative binding modes.

Kombo DC, Mazurov AA, Strachan JP, Bencherif M.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5105-13. doi: 10.1016/j.bmcl.2013.07.028. Epub 2013 Jul 23.

PMID:
23937977
7.

Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues.

Wei ZL, Petukhov PA, Xiao Y, Tückmantel W, George C, Kellar KJ, Kozikowski AP.

J Med Chem. 2003 Mar 13;46(6):921-4.

PMID:
12620069
8.

Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.

Tavares Xda S, Blum AP, Nakamura DT, Puskar NL, Shanata JA, Lester HA, Dougherty DA.

J Am Chem Soc. 2012 Jul 18;134(28):11474-80. doi: 10.1021/ja3011379. Epub 2012 Jul 9.

9.

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T.

J Med Chem. 2002 Jul 18;45(15):3235-45.

PMID:
12109907
10.

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.

Kombo DC, Mazurov A, Tallapragada K, Hammond PS, Chewning J, Hauser TA, Vasquez-Valdivieso M, Yohannes D, Talley TT, Taylor P, Caldwell WS.

Eur J Med Chem. 2011 Nov;46(11):5625-35. doi: 10.1016/j.ejmech.2011.09.033. Epub 2011 Sep 29.

PMID:
21986237
11.
12.

Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).

Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U.

J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q.

PMID:
20465311
13.

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor.

Cashin AL, Petersson EJ, Lester HA, Dougherty DA.

J Am Chem Soc. 2005 Jan 12;127(1):350-6.

PMID:
15631485
14.
15.

Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.

Ondachi P, Castro A, Luetje CW, Damaj MI, Mascarella SW, Navarro HA, Carroll FI.

J Med Chem. 2012 Jul 26;55(14):6512-22. doi: 10.1021/jm300575y. Epub 2012 Jul 11.

16.

Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.

Lee J, Davis CB, Rivero RA, Reitz AB, Shank RP.

Bioorg Med Chem Lett. 2000 May 15;10(10):1063-6.

PMID:
10843217
17.

Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors.

Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M.

ACS Chem Neurosci. 2010 Dec 15;1(12):796-809. doi: 10.1021/cn100073x. Epub 2010 Oct 7.

18.

Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.

Lin NH, Li Y, He Y, Holladay MW, Kuntzweiler T, Anderson DJ, Campbell JE, Arneric SP.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):631-3.

PMID:
11266158
19.
20.

Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.

Ji J, Schrimpf MR, Sippy KB, Bunnelle WH, Li T, Anderson DJ, Faltynek C, Surowy CS, Dyhring T, Ahring PK, Meyer MD.

J Med Chem. 2007 Nov 1;50(22):5493-508. Epub 2007 Oct 11.

PMID:
17929796
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