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Results: 1 to 20 of 108

1.

Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.

Kang S, Cooper G, Dunne SF, Luan CH, James Surmeier D, Silverman RB.

Bioorg Med Chem. 2013 Jul 15;21(14):4365-73. doi: 10.1016/j.bmc.2013.04.054. Epub 2013 Apr 28.

PMID:
23688558
[PubMed - indexed for MEDLINE]
2.

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2.

Chang CC, Cao S, Kang S, Kai L, Tian X, Pandey P, Dunne SF, Luan CH, Surmeier DJ, Silverman RB.

Bioorg Med Chem. 2010 May 1;18(9):3147-58. doi: 10.1016/j.bmc.2010.03.038. Epub 2010 Mar 19.

PMID:
20382537
[PubMed - indexed for MEDLINE]
3.

Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.

Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J.

J Neurosci. 2003 Jul 9;23(14):6041-9.

PMID:
12853422
[PubMed - indexed for MEDLINE]
Free Article
4.

Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.

Kang S, Cooper G, Dunne SF, Luan CH, Surmeier DJ, Silverman RB.

J Med Chem. 2013 Jun 13;56(11):4786-97. doi: 10.1021/jm4005048. Epub 2013 May 23. Erratum in: J Med Chem. 2013 Jul 25;56(14):5984.

PMID:
23651412
[PubMed - indexed for MEDLINE]
5.

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.

Ilijic E, Guzman JN, Surmeier DJ.

Neurobiol Dis. 2011 Aug;43(2):364-71. doi: 10.1016/j.nbd.2011.04.007. Epub 2011 Apr 16.

PMID:
21515375
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease.

Kang S, Cooper G, Dunne SF, Dusel B, Luan CH, Surmeier DJ, Silverman RB.

Nat Commun. 2012;3:1146. doi: 10.1038/ncomms2149.

PMID:
23093183
[PubMed - indexed for MEDLINE]
7.

Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive.

Lin M, Aladejebi O, Hockerman GH.

Eur J Pharmacol. 2011 Nov 16;670(1):105-13. doi: 10.1016/j.ejphar.2011.08.005. Epub 2011 Sep 2.

PMID:
21910984
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Role of voltage-gated L-type Ca2+ channel isoforms for brain function.

Striessnig J, Koschak A, Sinnegger-Brauns MJ, Hetzenauer A, Nguyen NK, Busquet P, Pelster G, Singewald N.

Biochem Soc Trans. 2006 Nov;34(Pt 5):903-9.

PMID:
17052224
[PubMed - indexed for MEDLINE]
9.

A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels.

Kwok TC, Hui K, Kostelecki W, Ricker N, Selman G, Feng ZP, Roy PJ.

PLoS Genet. 2008 May 9;4(5):e1000067. doi: 10.1371/journal.pgen.1000067. Erratum in: PLoS Genet. 2009 Feb;5(2). doi: 10.1371/annotation/c38f7645-c9d8-4371-b363-5a9099c75e83.

PMID:
18464914
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.

Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, Engel J, Striessnig J.

J Biol Chem. 2001 Jun 22;276(25):22100-6. Epub 2001 Apr 2.

PMID:
11285265
[PubMed - indexed for MEDLINE]
Free Article
11.

Selective inhibitory action of Biginelli-type dihydropyrimidines on depolarization-induced arterial smooth muscle contraction.

Cernecka H, Veizerova L, Mensikova L, Svetlik J, Krenek P.

J Pharm Pharmacol. 2012 May;64(5):735-41. doi: 10.1111/j.2042-7158.2012.01466.x. Epub 2012 Feb 8.

PMID:
22471370
[PubMed - indexed for MEDLINE]
12.

Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain.

Huber I, Wappl E, Herzog A, Mitterdorfer J, Glossmann H, Langer T, Striessnig J.

Biochem J. 2000 May 1;347 Pt 3:829-36.

PMID:
10769189
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structural model for dihydropyridine binding to L-type calcium channels.

Tikhonov DB, Zhorov BS.

J Biol Chem. 2009 Jul 10;284(28):19006-17. doi: 10.1074/jbc.M109.011296. Epub 2009 May 5.

PMID:
19416978
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Differential sensitivities of CaV1.2 IIS5-S6 mutants to 1,4-dihydropyridine analogs.

Hui K, Kwok TC, Kostelecki W, Leen J, Roy PJ, Feng ZP.

Eur J Pharmacol. 2009 Jan 14;602(2-3):255-61. doi: 10.1016/j.ejphar.2008.11.051. Epub 2008 Dec 3.

PMID:
19068212
[PubMed - indexed for MEDLINE]
16.

1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.

Ioan P, Carosati E, Micucci M, Cruciani G, Broccatelli F, Zhorov BS, Chiarini A, Budriesi R.

Curr Med Chem. 2011;18(32):4901-22. Review.

PMID:
22050742
[PubMed - indexed for MEDLINE]
17.

Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels.

Frick M, Siber G, Haller T, Mair N, Dietl P.

Biochem Pharmacol. 2001 May 1;61(9):1161-7.

PMID:
11301050
[PubMed - indexed for MEDLINE]
18.

Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.

Grabner M, Wang Z, Hering S, Striessnig J, Glossmann H.

Neuron. 1996 Jan;16(1):207-18.

PMID:
8562085
[PubMed - indexed for MEDLINE]
Free Article
19.

Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells.

Marcantoni A, Vandael DH, Mahapatra S, Carabelli V, Sinnegger-Brauns MJ, Striessnig J, Carbone E.

J Neurosci. 2010 Jan 13;30(2):491-504. doi: 10.1523/JNEUROSCI.4961-09.2010.

PMID:
20071512
[PubMed - indexed for MEDLINE]
Free Article
20.

Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.

Yamaguchi S, Zhorov BS, Yoshioka K, Nagao T, Ichijo H, Adachi-Akahane S.

Mol Pharmacol. 2003 Aug;64(2):235-48.

PMID:
12869628
[PubMed - indexed for MEDLINE]
Free Article

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