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Dual orientation of the outer membrane lipoprotein P6 of nontypeable haemophilus influenzae.

Michel LV, Snyder J, Schmidt R, Milillo J, Grimaldi K, Kalmeta B, Khan MN, Sharma S, Wright LK, Pichichero ME.

J Bacteriol. 2013 Jul;195(14):3252-9. doi: 10.1128/JB.00185-13. Epub 2013 May 17.


Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis.

Michel LV, Kalmeta B, McCreary M, Snyder J, Craig P, Pichichero ME.

Vaccine. 2011 Feb 11;29(8):1624-7. doi: 10.1016/j.vaccine.2010.12.082. Epub 2011 Jan 5.


Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children.

Khan MN, Kaur R, Pichichero ME.

FEMS Immunol Med Microbiol. 2012 Aug;65(3):439-47. doi: 10.1111/j.1574-695X.2012.00967.x. Epub 2012 May 9.


Th17 cells contribute to nontypeable Haemophilus influenzae-specific protective immunity induced by nasal vaccination with P6 outer membrane protein and ╬▒-galactosylceramide.

Noda K, Kodama S, Umemoto S, Nomi N, Hirano T, Suzuki M.

Microbiol Immunol. 2011 Aug;55(8):574-81. doi: 10.1111/j.1348-0421.2011.00352.x.


LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae.

Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, Petracca R, Rappuoli R, Pizza M, Norais N, Soriani M, Aric├▓ B.

MBio. 2015 Feb 24;6(2):e02575. doi: 10.1128/mBio.02575-14.


Evaluation of mixtures of purified Haemophilus influenzae outer membrane proteins in protection against challenge with nontypeable H. influenzae in the chinchilla otitis media model.

Green BA, Vazquez ME, Zlotnick GW, Quigley-Reape G, Swarts JD, Green I, Cowell JL, Bluestone CD, Doyle WJ.

Infect Immun. 1993 May;61(5):1950-7.


Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains.

Chang A, Kaur R, Michel LV, Casey JR, Pichichero M.

Hum Vaccin. 2011 Jan 1;7(1):102-5. Epub 2011 Jan 1.


A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization.

Hotomi M, Ikeda Y, Suzumoto M, Yamauchi K, Green BA, Zlotnick G, Billal DS, Shimada J, Fujihara K, Yamanaka N.

Vaccine. 2005 Jan 26;23(10):1294-300.


[Mouse macrophage-derived chemokine as an adjuvant enhances the protective effect of P6 protein vaccine of nontypeable Haemophilus influenzae].

Han X, Wang C, Qiao H, Zhang Y, Chang Y, Zhang Y.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Sep;30(9):913-6. Chinese.

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