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Results: 1 to 20 of 89

1.

Targeting Gli transcription activation by small molecule suppresses tumor growth.

Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B.

Oncogene. 2014 Apr 17;33(16):2087-97. doi: 10.1038/onc.2013.164. Epub 2013 May 20.

PMID:
23686308
[PubMed - indexed for MEDLINE]
2.

Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization.

Cho HK, Kim SY, Kim KH, Kim HH, Cheong J.

FEBS Lett. 2013 Apr 2;587(7):826-32. doi: 10.1016/j.febslet.2013.01.050. Epub 2013 Feb 8.

PMID:
23395608
[PubMed - indexed for MEDLINE]
Free Article
3.

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

Lauth M, Bergström A, Shimokawa T, Toftgård R.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. Epub 2007 May 9.

PMID:
17494766
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Gli as a novel therapeutic target in malignant pleural mesothelioma.

Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B.

PLoS One. 2013;8(3):e57346. doi: 10.1371/journal.pone.0057346. Epub 2013 Mar 6.

PMID:
23483902
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

PMID:
23762360
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.

PMID:
22949014
[PubMed - indexed for MEDLINE]
7.

TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.

Frontini M, Soutoglou E, Argentini M, Bole-Feysot C, Jost B, Scheer E, Tora L.

Mol Cell Biol. 2005 Jun;25(11):4638-49.

PMID:
15899866
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

Liu X, Vorontchikhina M, Wang YL, Faiola F, Martinez E.

Mol Cell Biol. 2008 Jan;28(1):108-21. Epub 2007 Oct 29.

PMID:
17967894
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW, Wang HY.

Clin Cancer Res. 2013 Apr 15;19(8):2014-24. doi: 10.1158/1078-0432.CCR-12-0349. Epub 2013 Mar 14.

PMID:
23493353
[PubMed - indexed for MEDLINE]
Free Article
10.

Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.

Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M.

J Biol Chem. 2010 Feb 5;285(6):4185-94. doi: 10.1074/jbc.M109.038232. Epub 2009 Dec 7.

PMID:
19996099
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

PMID:
24094913
[PubMed - indexed for MEDLINE]
12.

Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.

Li SH, Fu J, Watkins DN, Srivastava RK, Shankar S.

Mol Cell Biochem. 2013 Jan;373(1-2):217-27. doi: 10.1007/s11010-012-1493-6. Epub 2012 Nov 6.

PMID:
23129257
[PubMed - indexed for MEDLINE]
13.

Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.

Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A.

Pancreas. 2012 Mar;41(2):222-9. doi: 10.1097/MPA.0b013e31822896dd.

PMID:
22076568
[PubMed - indexed for MEDLINE]
14.

Vitamin D3 triggers antitumor activity through targeting hedgehog signaling in human renal cell carcinoma.

Dormoy V, Béraud C, Lindner V, Coquard C, Barthelmebs M, Brasse D, Jacqmin D, Lang H, Massfelder T.

Carcinogenesis. 2012 Nov;33(11):2084-93. doi: 10.1093/carcin/bgs255. Epub 2012 Jul 28.

PMID:
22843547
[PubMed - indexed for MEDLINE]
Free Article
15.

Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.

Malatesta M, Steinhauer C, Mohammad F, Pandey DP, Squatrito M, Helin K.

Cancer Res. 2013 Oct 15;73(20):6323-33. doi: 10.1158/0008-5472.CAN-12-4660. Epub 2013 Aug 13.

PMID:
23943798
[PubMed - indexed for MEDLINE]
16.

Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway.

Ramaswamy B, Lu Y, Teng KY, Nuovo G, Li X, Shapiro CL, Majumder S.

Cancer Res. 2012 Oct 1;72(19):5048-59. doi: 10.1158/0008-5472.CAN-12-1248. Epub 2012 Aug 8.

PMID:
22875023
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.

Hosoya T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M.

Chembiochem. 2008 May 5;9(7):1082-92. doi: 10.1002/cbic.200700511.

PMID:
18357592
[PubMed - indexed for MEDLINE]
18.

TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter.

Wright KJ, Marr MT 2nd, Tjian R.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12347-52. Epub 2006 Aug 8.

PMID:
16895980
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.

Saint M, Sawhney S, Sinha I, Singh RP, Dahiya R, Thakur A, Siddharthan R, Natarajan K.

Mol Cell Biol. 2014 May;34(9):1547-63. doi: 10.1128/MCB.01060-13. Epub 2014 Feb 18.

PMID:
24550006
[PubMed - indexed for MEDLINE]
20.

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.

Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P, Giorgi A, Steinkühler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A.

Nat Cell Biol. 2010 Feb;12(2):132-42. doi: 10.1038/ncb2013. Epub 2010 Jan 17.

PMID:
20081843
[PubMed - indexed for MEDLINE]

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