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Results: 1 to 20 of 97

1.

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M.

Nat Chem Biol. 2013 Jul;9(7):428-36. doi: 10.1038/nchembio.1257. Epub 2013 May 19.

PMID:
23685672
[PubMed - indexed for MEDLINE]
2.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
[PubMed - indexed for MEDLINE]
3.

A dimerization-dependent mechanism drives RAF catalytic activation.

Rajakulendran T, Sahmi M, Lefran├žois M, Sicheri F, Therrien M.

Nature. 2009 Sep 24;461(7263):542-5. doi: 10.1038/nature08314. Epub 2009 Sep 2.

PMID:
19727074
[PubMed - indexed for MEDLINE]
4.

Stabilization of a closed kinase conformation induces RAF dimerization.

[No authors listed]

Cancer Discov. 2013 Jul;3(7):715. doi: 10.1158/2159-8290.CD-RW2013-114. Epub 2013 May 30.

PMID:
23847340
[PubMed - indexed for MEDLINE]
5.

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72. doi: 10.1073/pnas.1102554108. Epub 2011 Mar 25.

PMID:
21441104
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB.

Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662.

PMID:
22113612
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

Garnett MJ, Rana S, Paterson H, Barford D, Marais R.

Mol Cell. 2005 Dec 22;20(6):963-9.

PMID:
16364920
[PubMed - indexed for MEDLINE]
Free Article
8.

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling.

McKay MM, Ritt DA, Morrison DK.

Curr Biol. 2011 Apr 12;21(7):563-8. doi: 10.1016/j.cub.2011.02.033. Epub 2011 Mar 31.

PMID:
21458265
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2.

Lee M.

Biochem Biophys Res Commun. 2006 Nov 17;350(2):450-6. Epub 2006 Sep 22.

PMID:
17010316
[PubMed - indexed for MEDLINE]
10.

Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.

Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M.

Mol Cell Biol. 2001 May;21(9):3192-205.

PMID:
11287623
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Allosteric activation of functionally asymmetric RAF kinase dimers.

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS.

Cell. 2013 Aug 29;154(5):1036-46. doi: 10.1016/j.cell.2013.07.046.

PMID:
23993095
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway.

Kim J, Yoon MY, Choi SL, Kang I, Kim SS, Kim YS, Choi YK, Ha J.

J Biol Chem. 2001 Jun 1;276(22):19102-10. Epub 2001 Mar 21.

PMID:
11262401
[PubMed - indexed for MEDLINE]
Free Article
13.

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

PMID:
19638615
[PubMed - indexed for MEDLINE]
Free Article
14.
15.

Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells.

Arthan D, Hong SK, Park JI.

Cancer Lett. 2010 Nov 1;297(1):31-41. doi: 10.1016/j.canlet.2010.04.021. Epub 2010 May 31.

PMID:
20570039
[PubMed - indexed for MEDLINE]
16.

Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.

Terai K, Matsuda M.

EMBO Rep. 2005 Mar;6(3):251-5.

PMID:
15711535
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.

Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR.

J Biol Chem. 2012 Jun 29;287(27):23128-40. doi: 10.1074/jbc.M112.343780. Epub 2012 May 17.

PMID:
22605333
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

RAF protein-serine/threonine kinases: structure and regulation.

Roskoski R Jr.

Biochem Biophys Res Commun. 2010 Aug 27;399(3):313-7. doi: 10.1016/j.bbrc.2010.07.092. Epub 2010 Jul 30. Review.

PMID:
20674547
[PubMed - indexed for MEDLINE]
19.

Regulation and role of Raf-1/B-Raf heterodimerization.

Rushworth LK, Hindley AD, O'Neill E, Kolch W.

Mol Cell Biol. 2006 Mar;26(6):2262-72.

PMID:
16508002
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.

Tzivion G, Luo Z, Avruch J.

Nature. 1998 Jul 2;394(6688):88-92.

PMID:
9665134
[PubMed - indexed for MEDLINE]

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