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Evaluation of [(18)F]-CP18 as a PET imaging tracer for apoptosis.

Su H, Chen G, Gangadharmath U, Gomez LF, Liang Q, Mu F, Mocharla VP, Szardenings AK, Walsh JC, Xia CF, Yu C, Kolb HC.

Mol Imaging Biol. 2013 Dec;15(6):739-47. doi: 10.1007/s11307-013-0644-9.


In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors.

Xia CF, Chen G, Gangadharmath U, Gomez LF, Liang Q, Mu F, Mocharla VP, Su H, Szardenings AK, Walsh JC, Zhao T, Kolb HC.

Mol Imaging Biol. 2013 Dec;15(6):748-57. doi: 10.1007/s11307-013-0646-7.


Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity.

Su H, Gorodny N, Gomez LF, Gangadharmath U, Mu F, Chen G, Walsh JC, Szardenings K, Kolb HC, Tamarappoo B.

Circ Cardiovasc Imaging. 2015 Feb;8(2):e001952. doi: 10.1161/CIRCIMAGING.114.001952.


Evaluation of chemotherapy response in VX2 rabbit lung cancer with 18F-labeled C2A domain of synaptotagmin I.

Wang F, Fang W, Zhang MR, Zhao M, Liu B, Wang Z, Hua Z, Yang M, Kumata K, Hatori A, Yamasaki T, Yanamoto K, Suzuki K.

J Nucl Med. 2011 Apr;52(4):592-9. doi: 10.2967/jnumed.110.081588. Epub 2011 Mar 18.


A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.

Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC.

Clin Cancer Res. 2014 Apr 15;20(8):2126-35. doi: 10.1158/1078-0432.CCR-13-2444. Epub 2014 Feb 26.


Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative.

Ross TL, Honer M, Lam PY, Mindt TL, Groehn V, Schibli R, Schubiger PA, Ametamey SM.

Bioconjug Chem. 2008 Dec;19(12):2462-70. doi: 10.1021/bc800356r.


Biodistribution and radiation dosimetry of 18F-CP-18, a potential apoptosis imaging agent, as determined from PET/CT scans in healthy volunteers.

Doss M, Kolb HC, Walsh JC, Mocharla V, Fan H, Chaudhary A, Zhu Z, Alpaugh RK, Lango MN, Yu JQ.

J Nucl Med. 2013 Dec;54(12):2087-92. doi: 10.2967/jnumed.113.119800. Epub 2013 Oct 17.


Biological evaluation of 3-[(18)F]fluoro-α-methyl-D-tyrosine (D-[(18)F]FAMT) as a novel amino acid tracer for positron emission tomography.

Ohshima Y, Hanaoka H, Tominaga H, Kanai Y, Kaira K, Yamaguchi A, Nagamori S, Oriuchi N, Tsushima Y, Endo K, Ishioka NS.

Ann Nucl Med. 2013 May;27(4):314-24. doi: 10.1007/s12149-013-0687-7. Epub 2013 Jan 23.


Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe.

Shen B, Jeon J, Palner M, Ye D, Shuhendler A, Chin FT, Rao J.

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10511-4. doi: 10.1002/anie.201303422. Epub 2013 Jul 23.


Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Chen DL, Zhou D, Chu W, Herrbrich P, Engle JT, Griffin E, Jones LA, Rothfuss JM, Geraci M, Hotchkiss RS, Mach RH.

Nucl Med Biol. 2012 Jan;39(1):137-44. doi: 10.1016/j.nucmedbio.2011.08.001. Epub 2011 Oct 26.


Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model.

Wang HE, Wu SY, Chang CW, Liu RS, Hwang LC, Lee TW, Chen JC, Hwang JJ.

Nucl Med Biol. 2005 May;32(4):367-75.


A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, MacFarlane M, Williams KJ, Whetton AD, Dive C.

Cell Death Dis. 2013 May 2;4:e613. doi: 10.1038/cddis.2013.137.


Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.

Hostetler ED, Sanabria-Bohórquez S, Eng W, Joshi AD, Patel S, Gibson RE, O'Malley S, Krause SM, Ryan C, Riffel K, Bi S, Okamoto O, Kawamoto H, Ozaki S, Ohta H, de Groot T, Bormans G, Depré M, de Hoon J, De Lepeleire I, Reynders T, Cook JJ, Burns HD, Egan M, Cho W, van Laere K, Hargreaves RJ.

Neuroimage. 2013 Mar;68:1-10. doi: 10.1016/j.neuroimage.2012.11.053. Epub 2012 Dec 11.


Positron emission tomography imaging of cell death with [(18)F]FPDuramycin.

Yao S, Hu K, Tang G, Liang X, Du K, Nie D, Jiang S, Zang L.

Apoptosis. 2014 May;19(5):841-50. doi: 10.1007/s10495-013-0964-x.


Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging.

Nguyen QD, Lavdas I, Gubbins J, Smith G, Fortt R, Carroll LS, Graham MA, Aboagye EO.

Clin Cancer Res. 2013 Jul 15;19(14):3914-24. doi: 10.1158/1078-0432.CCR-12-3814. Epub 2013 May 31.


Molecular imaging of neurovascular cell death in experimental cerebral stroke by PET.

Reshef A, Shirvan A, Waterhouse RN, Grimberg H, Levin G, Cohen A, Ulysse LG, Friedman G, Antoni G, Ziv I.

J Nucl Med. 2008 Sep;49(9):1520-8. doi: 10.2967/jnumed.107.043919. Epub 2008 Aug 14. Erratum in: J Nucl Med. 2011 Nov;52(11):1818.


Improved PET imaging of tumors in mice using a novel (18) F-folate conjugate with an albumin-binding entity.

Fischer CR, Groehn V, Reber J, Schibli R, Ametamey SM, Müller C.

Mol Imaging Biol. 2013 Dec;15(6):649-54. doi: 10.1007/s11307-013-0651-x.


18F-ML-10, a PET tracer for apoptosis: first human study.

Höglund J, Shirvan A, Antoni G, Gustavsson SÅ, Långström B, Ringheim A, Sörensen J, Ben-Ami M, Ziv I.

J Nucl Med. 2011 May;52(5):720-5. doi: 10.2967/jnumed.110.081786. Epub 2011 Apr 15. Erratum in: J Nucl Med. 2011 Nov;52(11):1818.


Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis.

Ohtsuki K, Akashi K, Aoka Y, Blankenberg FG, Kopiwoda S, Tait JF, Strauss HW.

Eur J Nucl Med. 1999 Oct;26(10):1251-8.


Noninvasive positron emission tomography imaging of cell death using a novel small-molecule probe, (18)F labeled bis(zinc(II)-dipicolylamine) complex.

Wang H, Tang X, Tang G, Huang T, Liang X, Hu K, Deng H, Yi C, Shi X, Wu K.

Apoptosis. 2013 Aug;18(8):1017-27. doi: 10.1007/s10495-013-0852-4.

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