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Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin.

Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W.

PLoS One. 2013 May 13;8(5):e62910. doi: 10.1371/journal.pone.0062910. Print 2013.


Gene expression profiling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation.

Meng QR, Gideon KM, Harbo SJ, Renne RA, Lee MK, Brys AM, Jones R.

Inhal Toxicol. 2006 Jul;18(8):555-68.


Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion.

Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):209-17. doi: 10.1165/rcmb.2011-0447OC. Epub 2012 Apr 19.


Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management.

Zeskind JE, Lenburg ME, Spira A.

Proc Am Thorac Soc. 2008 Dec 1;5(8):834-41. doi: 10.1513/pats.200807-074TH. Review.


Exposure to neonatal cigarette smoke causes durable lung changes but does not potentiate cigarette smoke-induced chronic obstructive pulmonary disease in adult mice.

McGrath-Morrow S, Malhotra D, Lauer T, Collaco JM, Mitzner W, Neptune E, Wise R, Biswal S.

Exp Lung Res. 2011 Aug;37(6):354-63. doi: 10.3109/01902148.2011.577268. Epub 2011 Jun 7.


Early response of gene clusters is associated with mouse lung resistance or sensitivity to cigarette smoke.

Cavarra E, Fardin P, Fineschi S, Ricciardi A, De Cunto G, Sallustio F, Zorzetto M, Luisetti M, Pfeffer U, Lungarella G, Varesio L.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L418-29. doi: 10.1152/ajplung.90382.2008. Epub 2008 Dec 31.


Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):758-66. doi: 10.1164/rccm.201408-1458OC.


Systemic inflammatory response to smoking in chronic obstructive pulmonary disease: evidence of a gender effect.

Faner R, Gonzalez N, Cruz T, Kalko SG, Agustí A.

PLoS One. 2014 May 15;9(5):e97491. doi: 10.1371/journal.pone.0097491. eCollection 2014.


Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers.

Zhou H, Alexis NE, Almond M, Donohue J, LaForce C, Bromberg PA, Peden DB.

Respir Med. 2009 Sep;103(9):1358-65. doi: 10.1016/j.rmed.2009.03.007. Epub 2009 Apr 10.


The search for common pathways underlying asthma and COPD.

Kaneko Y, Yatagai Y, Yamada H, Iijima H, Masuko H, Sakamoto T, Hizawa N.

Int J Chron Obstruct Pulmon Dis. 2013;8:65-78. doi: 10.2147/COPD.S39617. Epub 2013 Jan 25.


The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease.

Pauwels NS, Bracke KR, Maes T, Pilette C, Joos GF, Brusselle GG.

Exp Lung Res. 2010 Oct;36(8):469-83. doi: 10.3109/01902141003739723.


Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.

Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D.

Am J Respir Crit Care Med. 2012 Sep 1;186(5):412-9. doi: 10.1164/rccm.201111-2023OC. Epub 2012 Jun 28.


In utero environmental tobacco smoke exposure alters gene expression in lungs of adult BALB/c mice.

Rouse RL, Boudreaux MJ, Penn AL.

Environ Health Perspect. 2007 Dec;115(12):1757-66.


What genes tell us about the pathogenesis of asthma and chronic obstructive pulmonary disease.

Weiss ST.

Am J Respir Crit Care Med. 2010 Jun 1;181(11):1170-3. doi: 10.1164/rccm.201001-0069PP. Epub 2010 Feb 4.


Asthma and chronic obstructive pulmonary disease: common genes, common environments?

Postma DS, Kerkhof M, Boezen HM, Koppelman GH.

Am J Respir Crit Care Med. 2011 Jun 15;183(12):1588-94. doi: 10.1164/rccm.201011-1796PP. Epub 2011 Feb 4.


Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema.

Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, Deka R, Borchers MT.

J Immunol. 2008 Dec 1;181(11):8036-43.


Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.

Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14895-900. Epub 2004 Oct 5.


Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.

van der Deen M, Timens W, Timmer-Bosscha H, van der Strate BW, Scheper RJ, Postma DS, de Vries EG, Kerstjens HA.

Respir Res. 2007 Jul 7;8:49.


Inhaled insulin in patients with asthma and chronic obstructive pulmonary disease.

Mudaliar S, Henry RR.

Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S83-92.

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