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Results: 1 to 20 of 102

1.

Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.

Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL.

Neuron. 2013 May 8;78(3):510-22. doi: 10.1016/j.neuron.2013.03.017.

PMID:
23664616
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.

Zeng LH, Rensing NR, Zhang B, Gutmann DH, Gambello MJ, Wong M.

Hum Mol Genet. 2011 Feb 1;20(3):445-54. doi: 10.1093/hmg/ddq491. Epub 2010 Nov 9.

PMID:
21062901
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.

Mi R, Ma J, Zhang D, Li L, Zhang H.

J Genet Genomics. 2009 Jun;36(6):355-61. doi: 10.1016/S1673-8527(08)60124-1.

PMID:
19539245
[PubMed - indexed for MEDLINE]
4.

Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.

Zhang B, McDaniel SS, Rensing NR, Wong M.

PLoS One. 2013;8(2):e57445. doi: 10.1371/journal.pone.0057445. Epub 2013 Feb 20.

PMID:
23437388
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.

Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M.

J Neurosci. 2009 May 6;29(18):5926-37. doi: 10.1523/JNEUROSCI.0778-09.2009.

PMID:
19420259
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis.

McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y.

J Neurosci. 2012 Nov 7;32(45):15704-14. doi: 10.1523/JNEUROSCI.2392-12.2012.

PMID:
23136410
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders.

Ehninger D, Silva AJ.

Trends Mol Med. 2011 Feb;17(2):78-87. doi: 10.1016/j.molmed.2010.10.002. Epub 2010 Nov 4. Review.

PMID:
21115397
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.

Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garc├Ča-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R.

Cell Stem Cell. 2011 Nov 4;9(5):447-62. doi: 10.1016/j.stem.2011.09.008.

PMID:
22056141
[PubMed - indexed for MEDLINE]
Free Article
9.

Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.

Jansen LA, Uhlmann EJ, Crino PB, Gutmann DH, Wong M.

Epilepsia. 2005 Dec;46(12):1871-80.

PMID:
16393152
[PubMed - indexed for MEDLINE]
10.

Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.

Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC.

Ann Neurol. 2007 Feb;61(2):139-52.

PMID:
17279540
[PubMed - indexed for MEDLINE]
11.

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.

Neuman NA, Henske EP.

EMBO Mol Med. 2011 Apr;3(4):189-200. doi: 10.1002/emmm.201100131. Epub 2011 Mar 16. Review.

PMID:
21412983
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Modulation of TSC-mTOR signaling on immune cells in immunity and autoimmunity.

Yang H, Wang X, Zhang Y, Liu H, Liao J, Shao K, Chu Y, Liu G.

J Cell Physiol. 2014 Jan;229(1):17-26. doi: 10.1002/jcp.24426. Review.

PMID:
23804073
[PubMed - indexed for MEDLINE]
13.

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex.

Zeng LH, Ouyang Y, Gazit V, Cirrito JR, Jansen LA, Ess KC, Yamada KA, Wozniak DF, Holtzman DM, Gutmann DH, Wong M.

Neurobiol Dis. 2007 Nov;28(2):184-96. Epub 2007 Jul 21.

PMID:
17714952
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synaptic plasticity and learning in animal models of tuberous sclerosis complex.

Kirschstein T.

Neural Plast. 2012;2012:279834. doi: 10.1155/2012/279834. Epub 2012 Jul 15. Review.

PMID:
22848848
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.

Ehninger D, Han S, Shilyansky C, Zhou Y, Li W, Kwiatkowski DJ, Ramesh V, Silva AJ.

Nat Med. 2008 Aug;14(8):843-8. doi: 10.1038/nm1788. Epub 2008 Jun 22.

PMID:
18568033
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.

Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M.

Nature. 2012 Aug 30;488(7413):647-51. doi: 10.1038/nature11310.

PMID:
22763451
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex.

Xu L, Zeng LH, Wong M.

Neurobiol Dis. 2009 May;34(2):291-9.

PMID:
19385061
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex.

Hoogeveen-Westerveld M, Ekong R, Povey S, Mayer K, Lannoy N, Elmslie F, Bebin M, Dies K, Thompson C, Sparagana SP, Davies P, van Eeghen AM, Thiele EA, van den Ouweland A, Halley D, Nellist M.

Hum Mutat. 2013 Jan;34(1):167-75. doi: 10.1002/humu.22202. Epub 2012 Oct 11. Erratum in: Hum Mutat. 2013 Feb;34(2):408-10. van Eeghen, Agnies M [added]; Thiele, Elizabeth A [added].

PMID:
22903760
[PubMed - indexed for MEDLINE]
19.

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.

Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R.

Dis Model Mech. 2013 Sep;6(5):1185-97. doi: 10.1242/dmm.012096. Epub 2013 Jun 5.

PMID:
23744272
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.

Carson RP, Fu C, Winzenburger P, Ess KC.

Hum Mol Genet. 2013 Jan 1;22(1):140-52. doi: 10.1093/hmg/dds414. Epub 2012 Oct 9.

PMID:
23049074
[PubMed - indexed for MEDLINE]
Free PMC Article

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