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Items: 1 to 20 of 148

1.

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.

Mayne J, Ooi TC, Raymond A, Cousins M, Bernier L, Dewpura T, Sirois F, Mbikay M, Davignon J, Chrétien M.

Lipids Health Dis. 2013 May 10;12:70. doi: 10.1186/1476-511X-12-70.

2.

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M.

Clin Chem. 2011 Oct;57(10):1415-23. doi: 10.1373/clinchem.2011.165191. Epub 2011 Aug 3.

3.

Influence of PCSK9 polymorphisms on plasma lipids and response to atorvastatin treatment in Brazilian subjects.

Anderson JM, Cerda A, Hirata MH, Rodrigues AC, Dorea EL, Bernik MM, Bertolami MC, Faludi AA, Hirata RD.

J Clin Lipidol. 2014 May-Jun;8(3):256-64. doi: 10.1016/j.jacl.2014.02.008. Epub 2014 Mar 5.

PMID:
24793346
4.

Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9.

Humphries SE, Neely RD, Whittall RA, Troutt JS, Konrad RJ, Scartezini M, Li KW, Cooper JA, Acharya J, Neil A.

Clin Chem. 2009 Dec;55(12):2153-61. doi: 10.1373/clinchem.2009.129759. Epub 2009 Oct 1.

5.
6.

Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis.

Urban D, Pöss J, Böhm M, Laufs U.

J Am Coll Cardiol. 2013 Oct 15;62(16):1401-8. doi: 10.1016/j.jacc.2013.07.056. Epub 2013 Aug 21. Review.

7.

Proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism interacts with alcohol consumption to modulate serum lipid levels.

Aung LH, Yin RX, Wu DF, Cao XL, Hu XJ, Miao L.

Int J Med Sci. 2013;10(2):124-32. doi: 10.7150/ijms.5296. Epub 2012 Dec 30.

8.

PCSK9 R46L, lower LDL, and cardiovascular disease risk in familial hypercholesterolemia: a cross-sectional cohort study.

Saavedra YG, Dufour R, Davignon J, Baass A.

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2700-5. doi: 10.1161/ATVBAHA.114.304406. Epub 2014 Oct 2.

9.

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype.

Awan Z, Delvin EE, Levy E, Genest J, Davignon J, Seidah NG, Baass A.

Can J Cardiol. 2013 Aug;29(8):927-33. doi: 10.1016/j.cjca.2013.03.004. Epub 2013 Jun 3.

PMID:
23743349
10.

The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.

Aung LH, Yin RX, Miao L, Hu XJ, Yan TT, Cao XL, Wu DF, Li Q, Pan SL, Wu JZ.

Lipids Health Dis. 2011 Jan 13;10:5. doi: 10.1186/1476-511X-10-5.

11.

Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia.

Lye SH, Chahil JK, Bagali P, Alex L, Vadivelu J, Ahmad WA, Chan SP, Thong MK, Zain SM, Mohamed R.

PLoS One. 2013 Apr 8;8(4):e60729. doi: 10.1371/journal.pone.0060729. Print 2013.

12.

G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies.

Hussain Y, Ding Q, Connelly PW, Brunt JH, Ban MR, McIntyre AD, Huff MW, Gros R, Hegele RA, Feldman RD.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):213-21. doi: 10.1161/ATVBAHA.114.304326. Epub 2014 Nov 13.

13.

Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D.

J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7.

14.

Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.

Slimani A, Jelassi A, Jguirim I, Najah M, Rebhi L, Omezzine A, Maatouk F, Hamda KB, Kacem M, Rabès JP, Abifadel M, Boileau C, Rouis M, Slimane MN, Varret M.

Atherosclerosis. 2012 May;222(1):158-66. doi: 10.1016/j.atherosclerosis.2012.02.018. Epub 2012 Feb 19.

PMID:
22417841
15.

Molecular population genetics of PCSK9: a signature of recent positive selection.

Ding K, Kullo IJ.

Pharmacogenet Genomics. 2008 Mar;18(3):169-79. doi: 10.1097/FPC.0b013e3282f44d99.

16.

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, Hobbs HH.

Am J Hum Genet. 2006 Mar;78(3):410-22. Epub 2006 Jan 20.

17.

Plasma PCSK9 levels correlate with cholesterol in men but not in women.

Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC.

Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. Epub 2007 Jul 18.

PMID:
17645871
18.

Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels.

Chernogubova E, Strawbridge R, Mahdessian H, Mälarstig A, Krapivner S, Gigante B, Hellénius ML, de Faire U, Franco-Cereceda A, Syvänen AC, Troutt JS, Konrad RJ, Eriksson P, Hamsten A, van 't Hooft FM.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1526-34. doi: 10.1161/ATVBAHA.111.240549. Epub 2012 Mar 29.

19.

Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia.

Pisciotta L, Sallo R, Rabacchi C, Wunsch A, Calandra S, Bertolini S.

Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):831-5. doi: 10.1016/j.numecd.2011.04.003. Epub 2011 Sep 14.

PMID:
21920719
20.

Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes.

Strøm TB, Holla ØL, Cameron J, Berge KE, Leren TP.

Clin Chim Acta. 2010 Feb;411(3-4):229-33. doi: 10.1016/j.cca.2009.11.008. Epub 2009 Nov 13.

PMID:
19917273
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