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Results: 1 to 20 of 110

1.

Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3).

Guerrero M, Poddutoori R, Pinacho-Crisostomo F, Schaeffer MT, Brown SJ, Spicer T, Chase P, Ferguson J, Roberts E, Sanna G, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Aug 31 [updated 2013 Feb 25].

2.

Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4).

Guerrero M, Urbano M, Velaparthi S, Schaeffer MT, Brown SJ, Crisp M, Ferguson J, Hodder P, Rosen H, Oldstone M, Roberts E.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

3.

Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4).

Guerrero M, Urbano M, Velaparthi S, Zhao J, Schaeffer MT, Brown SJ, Crisp M, Ferguson J, Roberts E, Oldstone M, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 12 [updated 2011 Dec 12].

4.

Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4).

Oldstone M, Hodder P, Crisp M, Roberts E, Guerrero M, Urbano M, Velaparthi S, Zhao J, Rosen H, Schaeffer MT, Brown S, Ferguson J.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Feb 24 [updated 2010 Dec 16].

5.

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.

Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H.

J Biol Chem. 2004 Apr 2;279(14):13839-48. Epub 2004 Jan 19.

PMID:
14732717
[PubMed - indexed for MEDLINE]
Free Article
6.

Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.

Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H.

ACS Chem Biol. 2008 Aug 15;3(8):486-98. doi: 10.1021/cb800051m. Epub 2008 Jul 1.

PMID:
18590333
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.

Arikawa K, Takuwa N, Yamaguchi H, Sugimoto N, Kitayama J, Nagawa H, Takehara K, Takuwa Y.

J Biol Chem. 2003 Aug 29;278(35):32841-51. Epub 2003 Jun 16.

PMID:
12810709
[PubMed - indexed for MEDLINE]
Free Article
8.

Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors.

Siehler S, Manning DR.

Biochim Biophys Acta. 2002 May 23;1582(1-3):94-9. Review.

PMID:
12069815
[PubMed - indexed for MEDLINE]
9.

Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation.

Yamashita H, Kitayama J, Shida D, Yamaguchi H, Mori K, Osada M, Aoki S, Yatomi Y, Takuwa Y, Nagawa H.

J Surg Res. 2006 Jan;130(1):80-7. Epub 2005 Sep 23.

PMID:
16183075
[PubMed - indexed for MEDLINE]
10.

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

Vachal P, Toth LM, Hale JJ, Yan L, Mills SG, Chrebet GL, Koehane CA, Hajdu R, Milligan JA, Rosenbach MJ, Mandala S.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3684-7. Epub 2006 May 6.

PMID:
16682185
[PubMed - indexed for MEDLINE]
11.

Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.

Deng Q, Clemas JA, Chrebet G, Fischer P, Hale JJ, Li Z, Mills SG, Bergstrom J, Mandala S, Mosley R, Parent SA.

Mol Pharmacol. 2007 Mar;71(3):724-35. Epub 2006 Dec 14.

PMID:
17170199
[PubMed - indexed for MEDLINE]
Free Article
12.

Sphingosine-1-phosphate receptor signalling in the heart.

Means CK, Brown JH.

Cardiovasc Res. 2009 May 1;82(2):193-200. doi: 10.1093/cvr/cvp086. Epub 2009 Mar 12. Review.

PMID:
19282351
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N.

Biochim Biophys Acta. 2008 Sep;1781(9):483-8. doi: 10.1016/j.bbalip.2008.04.003. Epub 2008 Apr 22. Review.

PMID:
18472021
[PubMed - indexed for MEDLINE]
14.
15.

Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.

Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1.

PMID:
24135724
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes.

Rao TS, Lariosa-Willingham KD, Lin FF, Palfreyman EL, Yu N, Chun J, Webb M.

Brain Res. 2003 Nov 14;990(1-2):182-94.

PMID:
14568343
[PubMed - indexed for MEDLINE]
17.

Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR).

Kumar N, Solt LA, Conkright J, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Nuhant P, Burris T, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Jan 3 [updated 2011 Mar 11].

18.

Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors.

Waeber C, Blondeau N, Salomone S.

Drug News Perspect. 2004 Jul-Aug;17(6):365-82. Review.

PMID:
15334188
[PubMed - indexed for MEDLINE]
19.

Down-regulation of EDG5/S1P2 during myogenic differentiation results in the specific uncoupling of sphingosine 1-phosphate signalling to phospholipase D.

Meacci E, Cencetti F, Donati C, Nuti F, Farnararo M, Kohno T, Igarashi Y, Bruni P.

Biochim Biophys Acta. 2003 Sep 22;1633(3):133-42.

PMID:
14499732
[PubMed - indexed for MEDLINE]
20.

S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y.

FASEB J. 2004 Feb;18(2):341-3. Epub 2003 Dec 4.

PMID:
14657000
[PubMed - indexed for MEDLINE]
Free Article
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