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Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice.

Vanzelli AS, Medeiros A, Rolim N, Bartholomeu JB, Cunha TF, Bechara LR, Gomes ER, Mattos KC, Sirvente R, Salemi VM, Mady C, Negrao CE, Guatimosim S, Brum PC.

PLoS One. 2013 May 1;8(5):e62452. doi: 10.1371/journal.pone.0062452. Print 2013. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/ae03273e-5ed4-4c8f-a985-b39503b2e7e5. Salemi, Vera [corrected to Salemi, Vera Maria Cury]. PLoS One. 2013;8(7). doi:10.1371/annotation/f82c53c5-e15c-470c-b5e7-7732e1435cda. Bechara, Luiz G [corrected to Bechara, Luiz R G].


Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.

Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC.

J Appl Physiol (1985). 2008 Jan;104(1):103-9. Epub 2007 Nov 1.


Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.

Rolim NP, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC.

Physiol Genomics. 2007 May 11;29(3):246-52. Epub 2007 Jan 23.


[Effect of carvedilol on ryanodine receptor in heart failure].

Li R, Yi QJ, Qian YR, Liu XY.

Zhonghua Er Ke Za Zhi. 2005 Aug;43(8):603-7. Chinese.


Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.

Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, Rosa KT, Alves MM, Medeiros A, Mattos KC, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Ramires PR, Guatimosim S, Brum PC.

J Mol Cell Cardiol. 2008 Aug;45(2):240-9. doi: 10.1016/j.yjmcc.2008.05.011. Epub 2008 May 27.


Association of physical training with beta-blockers in heart failure in mice.

Vanzelli AS, Medeiros A, Sirvente Rde A, Salemi VM, Mady C, Brum PC.

Arq Bras Cardiol. 2010 Sep;95(3):373-80. Epub 2010 Jul 30.


Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.

Bueno CR Jr, Ferreira JC, Pereira MG, Bacurau AV, Brum PC.

J Appl Physiol (1985). 2010 Sep;109(3):702-9. doi: 10.1152/japplphysiol.00281.2010. Epub 2010 Jul 1.


[Effect of carvedilol and Radix astragali on ryanodine receptor in heart failure in mice].

Li R, Zhang Q, Yi QJ.

Zhonghua Er Ke Za Zhi. 2011 Jun;49(6):433-8. Chinese.


Comparison of low and high doses of carvedilol on restoration of cardiac function and calcium-handling proteins in rat failing heart.

Sun YL, Hu SJ, Wang LH, Hu Y, Zhou JY.

Clin Exp Pharmacol Physiol. 2005 Jul;32(7):553-60.


Pulmonary function, cardiac function, and exercise capacity in a follow-up of patients with congestive heart failure treated with carvedilol.

Guazzi M, Agostoni P, Matturri M, Pontone G, Guazzi MD.

Am Heart J. 1999 Sep;138(3 Pt 1):460-7.


CaMKII inhibition in heart failure, beneficial, harmful, or both.

Cheng J, Xu L, Lai D, Guilbert A, Lim HJ, Keskanokwong T, Wang Y.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1454-65. doi: 10.1152/ajpheart.00812.2011. Epub 2012 Jan 27.


Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats.

Sun YL, Hu SJ, Wang LH, Hu Y, Zhou JY.

Chest. 2005 Sep;128(3):1812-21.


Regression of left ventricular remodeling in chronic heart failure: Comparative and combined effects of captopril and carvedilol.

Khattar RS, Senior R, Soman P, van der Does R, Lahiri A.

Am Heart J. 2001 Oct;142(4):704-13.


Comparison of effects of ivabradine versus carvedilol in murine model with the Coxsackievirus B3-induced viral myocarditis.

Yue-Chun L, Teng Z, Na-Dan Z, Li-Sha G, Qin L, Xue-Qiang G, Jia-Feng L.

PLoS One. 2012;7(6):e39394. doi: 10.1371/journal.pone.0039394. Epub 2012 Jun 28.


Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol.

Fraga R, Franco FG, Roveda F, de Matos LN, Braga AM, Rondon MU, Rotta DR, Brum PC, Barretto AC, Middlekauff HR, Negrão CE.

Eur J Heart Fail. 2007 Jun-Jul;9(6-7):630-6. Epub 2007 May 1.


Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure.

Metra M, Covolo L, Pezzali N, Zacà V, Bugatti S, Lombardi C, Bettari L, Romeo A, Gelatti U, Giubbini R, Donato F, Dei Cas L.

Cardiovasc Drugs Ther. 2010 Feb;24(1):49-60. doi: 10.1007/s10557-010-6220-5.


Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.

Oliveira RS, Ferreira JC, Gomes ER, Paixão NA, Rolim NP, Medeiros A, Guatimosim S, Brum PC.

J Physiol. 2009 Aug 1;587(Pt 15):3899-910. doi: 10.1113/jphysiol.2009.173948. Epub 2009 Jun 8.


Late exercise training improves non-uniformity of transmural myocardial function in rats with ischaemic heart failure.

Aït Mou Y, Reboul C, Andre L, Lacampagne A, Cazorla O.

Cardiovasc Res. 2009 Feb 15;81(3):555-64. doi: 10.1093/cvr/cvn229. Epub 2008 Aug 14.


Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure.

Ruffolo RR Jr, Feuerstein GZ.

Cardiovasc Drugs Ther. 1997 May;11 Suppl 1:247-56. Review.

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