Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 108

Similar articles for PubMed (Select 23647843)


Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, Serganov AA, Liu Y, Jones RA, Hartmann G, Tuschl T, Patel DJ.

Cell. 2013 May 23;153(5):1094-107. doi: 10.1016/j.cell.2013.04.046. Epub 2013 May 3.


Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P.

Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019.


Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ.

Mol Cell. 2013 Jul 25;51(2):226-35. doi: 10.1016/j.molcel.2013.05.022. Epub 2013 Jun 6.


Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Kranzusch PJ, Lee AS, Berger JM, Doudna JA.

Cell Rep. 2013 May 30;3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23.


Structural mechanism of cytosolic DNA sensing by cGAS.

Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP.

Nature. 2013 Jun 20;498(7454):332-7. doi: 10.1038/nature12305. Epub 2013 May 30.


The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE.

Cell Rep. 2013 May 30;3(5):1355-61. doi: 10.1016/j.celrep.2013.05.009. Epub 2013 May 23.


Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ.

Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug 1.


Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Sun L, Wu J, Du F, Chen X, Chen ZJ.

Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012 Dec 20.


Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING.

Wu X, Wu FH, Wang X, Wang L, Siedow JN, Zhang W, Pei ZM.

Nucleic Acids Res. 2014 Jul;42(13):8243-57. doi: 10.1093/nar/gku569. Epub 2014 Jun 30.


Building unique bonds to fight misplaced DNA.

Fagundes CT, O'Neill LA.

Cell Res. 2013 Sep;23(9):1065-6. doi: 10.1038/cr.2013.81. Epub 2013 Jun 18.


cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Röhl I, Hopfner KP, Ludwig J, Hornung V.

Nature. 2013 Jun 20;498(7454):380-4. doi: 10.1038/nature12306. Epub 2013 May 30.


The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.

Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ.

Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014 Jan 23.


The cGAS-STING pathway for DNA sensing.

Xiao TS, Fitzgerald KA.

Mol Cell. 2013 Jul 25;51(2):135-9. doi: 10.1016/j.molcel.2013.07.004. Review.


OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.

Hornung V, Hartmann R, Ablasser A, Hopfner KP.

Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. Review.


Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU.

Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009.


Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ.

Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20.


A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.

Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR.

Nat Med. 2015 Apr;21(4):401-6. doi: 10.1038/nm.3813. Epub 2015 Mar 2.


Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage.

Päri M, Kuusksalu A, Lopp A, Kjaer KH, Justesen J, Kelve M.

Biochimie. 2014 Feb;97:200-9. doi: 10.1016/j.biochi.2013.10.015. Epub 2013 Oct 31.


Structures of yeast Apa2 reveal catalytic insights into a canonical AP₄A phosphorylase of the histidine triad superfamily.

Hou WT, Li WZ, Chen Y, Jiang YL, Zhou CZ.

J Mol Biol. 2013 Aug 9;425(15):2687-98. doi: 10.1016/j.jmb.2013.04.018. Epub 2013 Apr 26.


Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

Yi G, Brendel VP, Shu C, Li P, Palanathan S, Cheng Kao C.

PLoS One. 2013 Oct 21;8(10):e77846. doi: 10.1371/journal.pone.0077846. eCollection 2013.

Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk