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1.

The methylation hypothesis of pharmacoresistance in epilepsy.

Kobow K, El-Osta A, Blümcke I.

Epilepsia. 2013 May;54 Suppl 2:41-7. doi: 10.1111/epi.12183. Review.

PMID:
23646970
2.

The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis?

Kobow K, Blümcke I.

Epilepsia. 2011 Jul;52 Suppl 4:15-9. doi: 10.1111/j.1528-1167.2011.03145.x. Review.

PMID:
21732935
3.

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs.

Rogawski MA.

Epilepsia. 2013 May;54 Suppl 2:33-40. doi: 10.1111/epi.12182. Review.

PMID:
23646969
4.

Molecular and cellular mechanisms of pharmacoresistance in epilepsy.

Remy S, Beck H.

Brain. 2006 Jan;129(Pt 1):18-35. Epub 2005 Nov 29. Review.

5.

Mechanisms of drug resistance.

Löscher W.

Epileptic Disord. 2005 Sep;7 Suppl 1:S3-9. Review. Erratum in: Epileptic Disord. 2008 Jun;10(2):191.

PMID:
16120487
6.

Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches.

Potschka H.

Pharmacogenomics. 2010 Oct;11(10):1427-38. doi: 10.2217/pgs.10.126. Review.

PMID:
21047204
7.

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs.

Löscher W, Potschka H.

J Pharmacol Exp Ther. 2002 Apr;301(1):7-14. Review.

8.

[Drug resistance in epilepsy].

Czuczwar P, Kaczmarczyk K, Wierzchowska-Cioch E, Łuszczki JJ, Czuczwar SJ.

Przegl Lek. 2009;66(11):963-6. Review. Polish.

PMID:
20297639
9.

New horizons in the development of antiepileptic drugs: the search for new targets.

Löscher W, Schmidt D.

Epilepsy Res. 2004 Jul-Aug;60(2-3):77-159.

PMID:
15540387
10.

[Mechanisms of drug resistance in epilepsy].

Lasoń W.

Przegl Lek. 2006;63(11):1218-20. Review. Polish.

PMID:
17348420
11.

Clinical aspects and biological bases of drug-resistant epilepsies.

Regesta G, Tanganelli P.

Epilepsy Res. 1999 Apr;34(2-3):109-22. Review.

PMID:
10210025
12.

Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.

Delgado-Escueta AV, Bourgeois BF.

Epilepsia. 2008 Dec;49 Suppl 9:13-24. doi: 10.1111/j.1528-1167.2008.01922.x. Review.

PMID:
19087113
13.

High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.

Löscher W, Brandt C.

Epilepsia. 2010 Jan;51(1):89-97. doi: 10.1111/j.1528-1167.2009.02183.x. Epub 2009 Jun 26.

PMID:
19563347
14.

ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy.

Lazarowski A, Czornyj L, Lubienieki F, Girardi E, Vazquez S, D'Giano C.

Epilepsia. 2007;48 Suppl 5:140-9. Review. Erratum in: Epilepsia. 2007 Dec;48(12):2380.

PMID:
17910594
15.

Diminished response of CA1 neurons to antiepileptic drugs in chronic epilepsy.

Schaub C, Uebachs M, Beck H.

Epilepsia. 2007 Jul;48(7):1339-50. Epub 2007 Apr 18. Erratum in: Epilepsia. 2008 Jan;49(1):187.

PMID:
17441992
16.
17.

Impaired mitochondrial energy production: the basis of pharmacoresistance in epilepsy.

Yuen AW, Sander JW.

Med Hypotheses. 2011 Oct;77(4):536-40. doi: 10.1016/j.mehy.2011.06.025. Epub 2011 Jul 6.

PMID:
21737204
18.

[Drug resistance in partial epilepsy: epidemiology, mechanisms, pharmacogenetics and therapeutical aspects].

Mann MW, Pons G.

Neurochirurgie. 2008 May;54(3):259-64. doi: 10.1016/j.neuchi.2008.02.018. Epub 2008 Apr 15. Review. French.

PMID:
18417170
19.

A conceptual framework for the use of neuroimaging to study and predict pharmacoresistance in epilepsy.

Pohlmann-Eden B, Crocker CE, Schmidt MH.

Epilepsia. 2013 May;54 Suppl 2:75-9. doi: 10.1111/epi.12190. Review.

PMID:
23646977
20.

New Horizons in the development of antiepileptic drugs: Innovative strategies.

Löscher W, Schmidt D.

Epilepsy Res. 2006 Jun;69(3):183-272.

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