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Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence.

Hendrickson LM, Guildford MJ, Tapper AR.

Front Psychiatry. 2013 Apr 30;4:29. doi: 10.3389/fpsyt.2013.00029. eCollection 2013.


Nicotinic acetylcholine receptors containing the α6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons.

Liu L, Zhao-Shea R, McIntosh JM, Tapper AR.

Biochem Pharmacol. 2013 Oct 15;86(8):1194-200. doi: 10.1016/j.bcp.2013.06.015. Epub 2013 Jun 26.


Nicotinic acetylcholine receptors containing the α4 subunit modulate alcohol reward.

Liu L, Hendrickson LM, Guildford MJ, Zhao-Shea R, Gardner PD, Tapper AR.

Biol Psychiatry. 2013 Apr 15;73(8):738-46. doi: 10.1016/j.biopsych.2012.09.019. Epub 2012 Nov 9.


Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption.

Hendrickson LM, Zhao-Shea R, Pang X, Gardner PD, Tapper AR.

J Neurosci. 2010 Jul 28;30(30):10169-76. doi: 10.1523/JNEUROSCI.2601-10.2010.


Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits.

Liu L, Zhao-Shea R, McIntosh JM, Gardner PD, Tapper AR.

Mol Pharmacol. 2012 Apr;81(4):541-8. doi: 10.1124/mol.111.076661. Epub 2012 Jan 5.


Neurochemical and behavioral studies on ethanol and nicotine interactions.

Larsson A, Engel JA.

Neurosci Biobehav Rev. 2004 Jan;27(8):713-20. Review.


Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens.

Feduccia AA, Simms JA, Mill D, Yi HY, Bartlett SE.

Br J Pharmacol. 2014 Jul;171(14):3420-31. doi: 10.1111/bph.12690.


Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol.

Söderpalm B, Ericson M, Olausson P, Blomqvist O, Engel JA.

Behav Brain Res. 2000 Aug;113(1-2):85-96. Review.


Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, Marti F, Threlfell S, Cazala P, McIntosh JM, Changeux JP, Maskos U, Cragg SJ, Faure P.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7577-82. doi: 10.1073/pnas.1103000108. Epub 2011 Apr 18.


Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement.

Gotti C, Guiducci S, Tedesco V, Corbioli S, Zanetti L, Moretti M, Zanardi A, Rimondini R, Mugnaini M, Clementi F, Chiamulera C, Zoli M.

J Neurosci. 2010 Apr 14;30(15):5311-25. doi: 10.1523/JNEUROSCI.5095-09.2010.


The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area.

Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE.

PLoS One. 2013 Jul 15;8(7):e68300. doi: 10.1371/journal.pone.0068300. Print 2013.


Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.

Kamens HM, Andersen J, Picciotto MR.

Psychopharmacology (Berl). 2010 Mar;208(4):613-26. doi: 10.1007/s00213-009-1759-1.


Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats.

Bito-Onon JJ, Simms JA, Chatterjee S, Holgate J, Bartlett SE.

Addict Biol. 2011 Jul;16(3):440-9. doi: 10.1111/j.1369-1600.2010.00309.x. Epub 2011 Mar 11.


Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking.

Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12518-23. Epub 2007 Jul 11.


Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors.

Engle SE, McIntosh JM, Drenan RM.

Neuropharmacology. 2015 Apr;91:13-22. doi: 10.1016/j.neuropharm.2014.11.014. Epub 2014 Dec 4.


Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology.

Yang KC, Jin GZ, Wu J.

Acta Pharmacol Sin. 2009 Jun;30(6):740-51. doi: 10.1038/aps.2009.63. Review.


Varenicline and neuronal nicotinic acetylcholine receptors: a new approach to the treatment of co-occurring alcohol and nicotine addiction?

Nocente R, Vitali M, Balducci G, Enea D, Kranzler HR, Ceccanti M.

Am J Addict. 2013 Sep-Oct;22(5):453-9. doi: 10.1111/j.1521-0391.2013.12037.x. Epub 2013 May 15. Review.

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