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Items: 1 to 20 of 168

1.

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D.

Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT.

Neuropharmacology. 2013 Nov;74:96-107. doi: 10.1016/j.neuropharm.2013.04.035. Epub 2013 Apr 29.

2.

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.

Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, Bähring R, Bender RA.

FASEB J. 2014 May;28(5):2177-90. doi: 10.1096/fj.13-242032. Epub 2014 Jan 22.

3.

Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain.

Bruce MC, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D.

Biochem J. 2008 Oct 1;415(1):155-63. doi: 10.1042/BJ20071708.

PMID:
18498246
4.

A novel family of negative and positive allosteric modulators of NMDA receptors.

Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, Monaghan DT.

J Pharmacol Exp Ther. 2010 Dec;335(3):614-21. doi: 10.1124/jpet.110.174144. Epub 2010 Sep 21.

5.

Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.

Zhang W, Na T, Wu G, Jing H, Peng JB.

J Biol Chem. 2010 Nov 19;285(47):36586-96. doi: 10.1074/jbc.M110.175968. Epub 2010 Sep 15.

6.

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

Noyes NC, Hampton B, Migliorini M, Strickland DK.

Biochemistry. 2016 Mar 1;55(8):1204-13. doi: 10.1021/acs.biochem.5b01218. Epub 2016 Feb 17.

PMID:
26854353
7.

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2.

Ekberg J, Schuetz F, Boase NA, Conroy SJ, Manning J, Kumar S, Poronnik P, Adams DJ.

J Biol Chem. 2007 Apr 20;282(16):12135-42. Epub 2007 Feb 23.

8.

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.

Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W.

Mol Cell Biol. 2010 Mar;30(6):1541-54. doi: 10.1128/MCB.00013-10. Epub 2010 Jan 19.

9.

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E.

J Biol Chem. 2009 Mar 20;284(12):8185-94. doi: 10.1074/jbc.M806877200. Epub 2009 Jan 14.

10.

Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.

Delaney AJ, Sedlak PL, Autuori E, Power JM, Sah P.

J Neurophysiol. 2013 Mar;109(5):1391-402. doi: 10.1152/jn.00176.2012. Epub 2012 Dec 5.

11.

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.

Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1308-19. doi: 10.1152/ajprenal.00423.2010. Epub 2010 Sep 22.

12.

HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.

Edwin F, Anderson K, Patel TB.

J Biol Chem. 2010 Jan 1;285(1):255-64. doi: 10.1074/jbc.M109.030882. Epub 2009 Oct 28.

13.

Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition.

Wang J, Peng Q, Lin Q, Childress C, Carey D, Yang W.

J Biol Chem. 2010 Apr 16;285(16):12279-88. doi: 10.1074/jbc.M109.086405. Epub 2010 Feb 19.

14.

Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8.

Scudder SL, Goo MS, Cartier AE, Molteni A, Schwarz LA, Wright R, Patrick GN.

J Neurosci. 2014 Dec 10;34(50):16637-49. doi: 10.1523/JNEUROSCI.2452-14.2014.

15.

Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels.

Krzystanek K, Rasmussen HB, Grunnet M, Staub O, Olesen SP, Abriel H, Jespersen T.

Heart Rhythm. 2012 Mar;9(3):440-8. doi: 10.1016/j.hrthm.2011.10.026. Epub 2011 Oct 22. Erratum in: Heart Rhythm. 2012 May;9(5):845.

PMID:
22024150
16.

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking.

Lin A, Hou Q, Jarzylo L, Amato S, Gilbert J, Shang F, Man HY.

J Neurochem. 2011 Oct;119(1):27-39. doi: 10.1111/j.1471-4159.2011.07221.x. Epub 2011 Mar 17.

17.

Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.

Zeng F, Xu J, Harris RC.

FASEB J. 2009 Jun;23(6):1935-45. doi: 10.1096/fj.08-121947. Epub 2009 Feb 4.

18.
19.

Ubiquitylation of voltage-gated sodium channels.

Laedermann CJ, Decosterd I, Abriel H.

Handb Exp Pharmacol. 2014;221:231-50. doi: 10.1007/978-3-642-41588-3_11. Review.

PMID:
24737239
20.

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.

Wang C, An J, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L.

Biochem J. 2012 Jun 1;444(2):279-89. doi: 10.1042/BJ20111983.

PMID:
22385262
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