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Results: 1 to 20 of 132

1.

Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma.

Metz CH, Scheulen M, Bornfeld N, Lohmann D, Zeschnigk M.

Cancer Med. 2013 Apr;2(2):208-15. doi: 10.1002/cam4.61. Epub 2013 Feb 14.

PMID:
23634288
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mutations in GNA11 in uveal melanoma.

Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC.

N Engl J Med. 2010 Dec 2;363(23):2191-9. doi: 10.1056/NEJMoa1000584. Epub 2010 Nov 17.

PMID:
21083380
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Detection rate and prognostic value of circulating tumor cells and circulating tumor DNA in metastatic uveal melanoma.

Bidard FC, Madic J, Mariani P, Piperno-Neumann S, Rampanou A, Servois V, Cassoux N, Desjardins L, Milder M, Vaucher I, Pierga JY, Lebofsky R, Stern MH, Lantz O.

Int J Cancer. 2014 Mar 1;134(5):1207-13. doi: 10.1002/ijc.28436. Epub 2013 Sep 3.

PMID:
23934701
[PubMed - indexed for MEDLINE]
4.

Pyrophosphorolysis-activated polymerization detects circulating tumor DNA in metastatic uveal melanoma.

Madic J, Piperno-Neumann S, Servois V, Rampanou A, Milder M, Trouiller B, Gentien D, Saada S, Assayag F, Thuleau A, Nemati F, Decaudin D, Bidard FC, Desjardins L, Mariani P, Lantz O, Stern MH.

Clin Cancer Res. 2012 Jul 15;18(14):3934-41. doi: 10.1158/1078-0432.CCR-12-0309. Epub 2012 May 29.

PMID:
22645051
[PubMed - indexed for MEDLINE]
Free Article
5.

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.

Koopmans AE, Vaarwater J, Paridaens D, Naus NC, Kilic E, de Klein A; Rotterdam Ocular Melanoma Study group.

Br J Cancer. 2013 Jul 23;109(2):493-6. doi: 10.1038/bjc.2013.299. Epub 2013 Jun 18.

PMID:
23778528
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner.

Khalili JS, Yu X, Wang J, Hayes BC, Davies MA, Lizee G, Esmaeli B, Woodman SE.

Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.

PMID:
22733540
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance.

Ambrosini G, Pratilas CA, Qin LX, Tadi M, Surriga O, Carvajal RD, Schwartz GK.

Clin Cancer Res. 2012 Jul 1;18(13):3552-61. doi: 10.1158/1078-0432.CCR-11-3086. Epub 2012 May 1.

PMID:
22550165
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Immunohistochemical and molecular pathology of ocular uveal melanocytoma: evidence for somatic GNAQ mutations.

Mudhar HS, Doherty R, Salawu A, Sisley K, Rennie IG.

Br J Ophthalmol. 2013 Jul;97(7):924-8. doi: 10.1136/bjophthalmol-2013-303291. Epub 2013 May 17.

PMID:
23685997
[PubMed - indexed for MEDLINE]
9.

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma.

Dono M, Angelini G, Cecconi M, Amaro A, Esposito AI, Mirisola V, Maric I, Lanza F, Nasciuti F, Viaggi S, Gualco M, Bandelloni R, Truini M, Coviello DA, Zupo S, Mosci C, Pfeffer U.

Br J Cancer. 2014 Feb 18;110(4):1058-65. doi: 10.1038/bjc.2013.804. Epub 2014 Jan 14.

PMID:
24423917
[PubMed - indexed for MEDLINE]
10.

Skin metastases in metastatic uveal melanoma: GNAQ/GNA11 mutational analysis as a valuable tool.

Tsianakas A, Böhm MR, Getova V, Metze D, Eter N, Spieker T, Bräuninger A, Luger T, Schiller M, Sunderkötter C.

Br J Dermatol. 2013 Jul;169(1):160-3. doi: 10.1111/bjd.12291.

PMID:
23464620
[PubMed - indexed for MEDLINE]
11.

Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation.

Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE.

Invest Ophthalmol Vis Sci. 2014 Apr 7;55(4):2130-9. doi: 10.1167/iovs.13-13468.

PMID:
24595385
[PubMed - indexed for MEDLINE]
12.

High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.

Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK.

Invest Ophthalmol Vis Sci. 2012 Oct 9;53(11):6991-6. doi: 10.1167/iovs.12-10427.

PMID:
22977135
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways.

Wu X, Li J, Zhu M, Fletcher JA, Hodi FS.

Mol Cancer Ther. 2012 Sep;11(9):1905-14. doi: 10.1158/1535-7163.MCT-12-0121. Epub 2012 May 31.

PMID:
22653968
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death.

Ambrosini G, Musi E, Ho AL, de Stanchina E, Schwartz GK.

Mol Cancer Ther. 2013 May;12(5):768-76. doi: 10.1158/1535-7163.MCT-12-1020. Epub 2013 Feb 26.

PMID:
23443802
[PubMed - indexed for MEDLINE]
Free Article
15.

Exome sequencing reveals the likely involvement of SOX10 in uveal melanoma.

Das D, Kaur I, Ali MJ, Biswas NK, Das S, Kumar S, Honavar SG, Maitra A, Chakrabarti S, Majumder PP.

Optom Vis Sci. 2014 Jul;91(7):e185-92. doi: 10.1097/OPX.0000000000000309.

PMID:
24927141
[PubMed - indexed for MEDLINE]
16.

Lack of GNAQ germline mutations in uveal melanoma patients with high risk for hereditary cancer predisposition.

Abdel-Rahman MH, Pilarski R, Massengill JB, Christopher BB, Davidorf FH.

Fam Cancer. 2011 Jun;10(2):319-21. doi: 10.1007/s10689-010-9401-2.

PMID:
21072599
[PubMed - indexed for MEDLINE]
17.

Lack of oncogenic GNAQ mutations in melanocytic lesions of the conjunctiva as compared to uveal melanoma.

Dratviman-Storobinsky O, Cohen Y, Frenkel S, Pe'er J, Goldenberg-Cohen N.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6180-2. doi: 10.1167/iovs.10-5677. Epub 2010 Jul 14.

PMID:
20631239
[PubMed - indexed for MEDLINE]
Free Article
18.

Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma.

Bauer J, Kilic E, Vaarwater J, Bastian BC, Garbe C, de Klein A.

Br J Cancer. 2009 Sep 1;101(5):813-5. doi: 10.1038/sj.bjc.6605226. Epub 2009 Aug 4.

PMID:
19654573
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival.

Abdel-Rahman MH, Cebulla CM, Verma V, Christopher BN, Carson WE 3rd, Olencki T, Davidorf FH.

Exp Eye Res. 2012 Jul;100:26-31. doi: 10.1016/j.exer.2012.04.010. Epub 2012 May 5.

PMID:
22569040
[PubMed - indexed for MEDLINE]
20.

Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.

Ho AL, Musi E, Ambrosini G, Nair JS, Deraje Vasudeva S, de Stanchina E, Schwartz GK.

PLoS One. 2012;7(7):e40439. doi: 10.1371/journal.pone.0040439. Epub 2012 Jul 10.

PMID:
22808163
[PubMed - indexed for MEDLINE]
Free PMC Article

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